A novel multi-component synthesis of 4-arylaminoquinazolines

Recent developments in use of heteropolyacids, their salts and polyoxometalates in organic synthesis

“…It has been proved that Keggin type heteropolyacids are efficient, reusable and eco-friendly heterogeneous inorganic catalysts. The advantages of this method are the easy work-up procedure and high yields of products (Scheme 22) [68]. …”

One-pot three-component synthesis of β-acetamido carbonyl compounds catalyzed by heteropoly acids

“…In this study and in continuation of our works with HPAs as a catalyst in organic reactions [36][37][38][39][40][41][42][43][44], we wish to report the synthesis of a family of b-acetamido carbonyl compounds (4a-4i) via a Mannich-type three-component condensation of an aldehyde (1), acetamide (2), and dimedone (3) The mechanism of the Mannich reaction has been extensively investigated [45,46]. The reaction can proceed under both acidic and basic conditions, but acidic conditions are more common.…”

Orthoesters: Multiple Role Players in Organic Synthesis

“…Treatment of 2‐aminobenzamides with TEOF or TMOF and aniline derivatives in the presence of catalytic amounts of Keggin‐type heteropoly acids namely H 6 [PMo 9 V 3 O 40 ], H 5 [PMo 10 V 2 O 40 ], H 4 [PMo 11 VO 40 ], and H 3 [PMo 12 O 40 ] under reflux produced 4‐arylaminoquinazolines in high yields . Noteworthy are the differences in the reactivity pattern of 2‐aminobenzamide in IL a and IL b on treatment with TEOF , which was associated with chemoselectivity.…”