A novel mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of poloxamer

Chun, Myung-Kwan; Cho, Chong‐Su; Choi, Hoo‐Kyun

doi:10.1002/1097-4628(20010222)79:8<1525::aid-app200>3.0.co;2-h

Cited by 34 publications

(13 citation statements)

References 11 publications

(10 reference statements)

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“…When no Carbopol was used in felodipine tablets, the release rate was rapid and approximately 70% of felodipine was released in 2 h. On the other hand Carbopol at 2.5% slightly reduced this release rate, and when this was increased to 5 or 10% the release rate over the first 24h was of almost zero order, which may be due in part to an interaction between Carbopol and the poloxamer. We showed in a previous study that Carbopol can form a polymer complex with poloxamer by hydrogen bonding, and that this results in the slow disintegration of a tablet matrix (Chun et al, 2001). As a result, high poloxamer concentration can be maintained within a tablet and solubilized felodipine slowly diffuses from the tablet matrix.…”

Section: Development Of a Controlled Release Felodipine Tabletmentioning

confidence: 96%

Effect of poloxamer on the dissolution of felodipine and preparation of controlled release matrix tablets containing felodipine

et al. 2008

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The effects of poloxamer and HPMC on the dissolution rate of felodipine were investigated and a felodipine controlled release tablet was developed by increasing the water solubility of felodipine and using swelling polymer to control release rate. Milling of felodipine slightly increased the dissolution rate of felodipine when compared with physical mixture. XRD results indicated that felodipine remained in the crystalline form even after co-milling with poloxamer. Improved dissolution rates after co-milling with HPMC and poloxamer were due to both solubilization effect of polymer and milling. The effect of poloxamer on dissolution rate was more significant than that of HPMC. Based on increased solubility of felodipine in the presence of poloxamer, it was concluded that the improved dissolution rate of felodipine was mainly due to a high local concentration of poloxamer around felodipine. Controlled release felodipine tablets were prepared using poloxamer as a solubilizing agent and Carbopol as a controlled release matrix.

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Section: Development Of a Controlled Release Felodipine Tabletmentioning

confidence: 96%

Effect of poloxamer on the dissolution of felodipine and preparation of controlled release matrix tablets containing felodipine

et al. 2008

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“…Template polymerization is a process of forming a polymer chain in the presence of a macromolecule (template). Complex formation between the polymer chain formed and the template has been generally attributed to hydrogen bonding, electrostatic forces, or covalent bonding 6–10. The presence of such a template during polymerization is known to have kinetic and structural effects 10.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of poly(vinyl pyrrolidone)/poly(acrylic acid) interpolymer complex prepared by template polymerization of acrylic acid: Effect of reaction solvent and molecular weight of template

Chun

Cho

Choi

2004

J of Applied Polymer Sci

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Poly(vinyl pyrrolidone) (PVP)/poly(acrylic acid) (PAA) interpolymer complexes were prepared, in ethanol or dimethylformamide (DMF), by template polymerization of acrylic acid in the presence of PVP (MW: 42.5 or 1100 K) used as the template. FTIR analysis showed that the complexes were formed through hydrogen bonding between the carboxyl groups of the PAA and the carbonyl groups of the PVP. The glass-transition temperature (T g ) of the complex, prepared in ethanol, was higher than that of the component polymers, whereas the T g of the complex, prepared in DMF, was located between that of the component polymers. The dissolution rate of the complex was affected by the molecular weight of the PVP and the reaction solvent. The release rate of ketoprofen from the complexes showed a pH dependency, and was slower at a lower pH. The ketoprofen release rate from the complex was controlled mainly by the dissolution rate of the complex above the pK a of PAA (4.75) and by the diffusion rate below the pK a .

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“…The polymer's mucoadhesive properties play an important role, as the delivery system can provide an intimate contact with the absorptive tissue, thus providing a steep concentration gradient of the incorporated drug, driving its absorption. It has also been reported that systems gained by chemical combination of pluronics and polyacrylic acid exhibit enhanced adhesive properties (18). In addition to prolonged residence time of the drug delivery system on mucosal surfaces, nanoparticles provide a large surface area to be exploited for contact with the epithelium.…”

Section: Discussionmentioning

confidence: 99%

Development and in vivo evaluation of a new oral nanoparticulate dosage form for leuprolide based on polyacrylic acid

Iqbal¹,

Vigl²,

Moser³

et al. 2011

Drug Delivery

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A novel mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of poloxamer

Cited by 34 publications

References 11 publications

Effect of poloxamer on the dissolution of felodipine and preparation of controlled release matrix tablets containing felodipine

Effect of poloxamer on the dissolution of felodipine and preparation of controlled release matrix tablets containing felodipine

Characteristics of poly(vinyl pyrrolidone)/poly(acrylic acid) interpolymer complex prepared by template polymerization of acrylic acid: Effect of reaction solvent and molecular weight of template

Development and in vivo evaluation of a new oral nanoparticulate dosage form for leuprolide based on polyacrylic acid

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