A Novel Mucoadhesive Polymer Film Composed of Carbopol, Poloxamer and Hydroxypropylmethylcellulose

Kim, Tae Hee; Ahn, Jae Soon; Choi, Hoo Kyun; Choi, Yun Jaie; Cho, Chong Su

doi:10.1007/bf02977622

Cited by 30 publications

(18 citation statements)

References 14 publications

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“…As general ob- and correlated it with the intermolecular hydrogen bonds among the carbonyl groups of the polymer [14]. As shown by other authors this band is the most aected by the conformational changes of the polymeric chains induced by hydration or neutralization [12,14]. Other bands appear at 629, 801, 1172, 1241, 1446, 1714 cm −1 (Fig.…”

Section: Resultssupporting

confidence: 72%

IR and Raman Investigation of Some Poly(acrylic) Acid Gels in Aqueous and Neutralized State

et al. 2015

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The modication of local polymeric conformation of poly(acrylic) acid (PAA), induced by hydration and neutralization with triethanol amine (TEA), was investigated by IR and Raman spectroscopy. The eect of water is the perturbation of hydrogen bonds established between dierent polymeric chains and the modication of the local conformation of the polymer. The neutralization with TEA aects the carboxylic groups and modies the local conformation of the polymer. These modications are correlated with the shift and the modication of the characteristics of IR and Raman spectra.

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Section: Resultssupporting

confidence: 72%

IR and Raman Investigation of Some Poly(acrylic) Acid Gels in Aqueous and Neutralized State

et al. 2015

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“…Although F2 had the highest in vitro DE, it had the lowest inhibition zone, which may be due to its low mucoadhesion time that lead to decrease the contact time between the film and the agar media. The two formulations F4 and F7 had no significant difference in their DE (P > 0.05) but F7 had higher inhibition zone, which may be assigned to the higher mucoadhesion time due to presence of high concentration of carbopol which is known by his ability to increase the mucoadhesion force [14] and thus give more contact time. Therefore, increasing the residence time of the drug leading to increase its local concentration and its effectiveness.…”

Section: Microbiological Effectmentioning

confidence: 90%

“…The study was performed at 37°C with 100 rpm. [14,15] The films (2 cm × 2 cm diameter) were fixed on watch glasses covered with stainless screen about 150 mesh/inch, which was cut to fit circle on the watch glass, the back of this assembly was covered with aluminum foil to prevent drug dissolution from this side and then the hall assembly was immersed in the dissolution medium. Samples were collected periodically at 10, 20, 30, 45, 60, 90, 120, 150, and 180 min and replaced with fresh medium.…”

Section: In Vitro Release Of Ciprofloxacin From Its Filmsmentioning

confidence: 99%

Formulation and evaluation of taste-masked ciprofloxacin bioadhesive dental films

Abdou¹,

Fuda²,

Soliman³

2013

Asian J Pharm

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C iprofloxacin is a broad-spectrum anti-infective agent of the fluoroquinolons. It has activity against periodontal pathogens.Saccharin is one of the most widely used artificial sweetening agents. The complex of ciprofloxacin saccharinate was prepared to improve organoleptic properties of ciprofloxacin and it was characterized using fourier transform infrared analysis, differential scanning calorimetric, photomicrographs, solubility determination of the complex and ultraviolet-scanning in different media as well as determination of the actual drug content. Eight formulations of ciprofloxacin saccharinate bioadhesive dental films were prepared using chitosan, carbopol 934, and hydroxypropyl methyl cellulose (HPMC). The prepared films were evaluated for their physic-mechanical properties including film thickness, weight uniformity, and tensile strength, folding endurance, surface pH, and percentage elongation. In addition, mucoadhesive performance of films, drug content and in vitro release of ciprofloxacin from different films were determined. The best formulations were selected and were subjected to stability study at 40°C and 75% relative humidity for 3 months and microbiological test. Results revealed that the use of mixture of carbopol and HPMC with chitosan improved physical and chemical properties of the prepared films. Microbiological results showed that, F 7 had the highest inhibition zone which may be due to the presence of high concentration of carbopol 934 that leads to high mucoadhesive time.

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“…Physical-chemical properties of the controlled-release systems containing chitosan and HPMC using films for transdermal and oral models, such as pH, tension-elongation, uniformity of drug diffusion and solubility 11,12,13,14 , have been studied proving beneficial for systems as a future application 15 .…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and antimicrobial evaluation of chitosan and hydroxypropyl methylcellulose films for prolonged release of pilocarpine

et al. 2014

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Introduction: The use of prolonged local drug delivery to the oral cavity offers multiple benefits, such as increasing the pharmacological action in the desirable local site and reducing the usual dose and the adverse effects. Pilocarpine is a cholinergic drug approved by the FDA for the treatment of glandular hypofunction; however, the extent of its adverse effects limits its use. Objective: The main aim of this study was to analyze the physical and chemical properties of films, including pH, thickness, solubility, consistency and the ability to release pilocarpine for a prolonged time. Additionally, the antimicrobial activity in two opportunistic pathogens in hyposialia (Streptococcus mutans and Candida albicans) was also assessed. Methodology: Chitosan and HPMC (Methocel K4M CR) films were prepared in 1% acetic acid and pilocarpine was added under magnetic stirring. PH, thickness and time of solubility in artificial saliva, as well as diffusion and drug release kinetics per cm 2 (OD=420nm) were assessed by spectrophotometry. The antimicrobial activity was tested by disk diffusion test against St. mutans ATCC 700610 and C. albicans ATCC 90029 at concentrations of hyposalivation (1.44x1.2x10 6 CFU and 10 3 CFU, respectively). Results: All the films, except for Hydroxypropyl methylcellulose / Pilocarpine formulation, were found to have optimal physical-chemical properties for handling, maintaining drug diffusion in 76% per cm 2 for four hours extended-release without showing antimicrobial activity at concentrations of hyposalivation. Conclusion: The films had optimum handling properties and a constant drug release; however, antimicrobial activity was not found.

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A Novel Mucoadhesive Polymer Film Composed of Carbopol, Poloxamer and Hydroxypropylmethylcellulose

Cited by 30 publications

References 14 publications

IR and Raman Investigation of Some Poly(acrylic) Acid Gels in Aqueous and Neutralized State

IR and Raman Investigation of Some Poly(acrylic) Acid Gels in Aqueous and Neutralized State

Formulation and evaluation of taste-masked ciprofloxacin bioadhesive dental films

Physicochemical and antimicrobial evaluation of chitosan and hydroxypropyl methylcellulose films for prolonged release of pilocarpine

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