2014
DOI: 10.17126/joralres.2015.007
|View full text |Cite
|
Sign up to set email alerts
|

Physicochemical and antimicrobial evaluation of chitosan and hydroxypropyl methylcellulose films for prolonged release of pilocarpine

Abstract: Introduction: The use of prolonged local drug delivery to the oral cavity offers multiple benefits, such as increasing the pharmacological action in the desirable local site and reducing the usual dose and the adverse effects. Pilocarpine is a cholinergic drug approved by the FDA for the treatment of glandular hypofunction; however, the extent of its adverse effects limits its use. Objective: The main aim of this study was to analyze the physical and chemical properties of films, including pH, thickness, solub… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2015
2015
2024
2024

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(2 citation statements)
references
References 23 publications
0
2
0
Order By: Relevance
“…Prolonged-release films of pilocarpine: Because of the wide variety of adverse effects that sialogogue drugs can produce, researchers have looked for different ways to administer these drugs in order to mitigate their adverse effects 70 .…”
Section: Rodríguez J Martínez G Rodríguez N Chapa M and Solís Jmentioning
confidence: 99%
“…Prolonged-release films of pilocarpine: Because of the wide variety of adverse effects that sialogogue drugs can produce, researchers have looked for different ways to administer these drugs in order to mitigate their adverse effects 70 .…”
Section: Rodríguez J Martínez G Rodríguez N Chapa M and Solís Jmentioning
confidence: 99%
“…2,3 This condition can occur in isolation as primary Sjögren's syndrome, 4 or it can manifest as secondary when presenting together with other autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, 5 sclerosis, among others. 6 Due to a decrease in salivary flow, patients with Sjögren's syndrome have an increase incidence of dental caries, periodontal disease, 7 mucositis, neoplasms, tooth loss, 8 as well as Candida albicans 9 infections.…”
Section: Introductionmentioning
confidence: 99%