A novel molecularly imprinted polymer thin film as biosensor for uric acid

Chen, Po‐Yen; Vittal, R.; Nien, Po-Chin; Liou, Guey‐Sheng; Ho, Kuo–Chuan

doi:10.1016/j.talanta.2009.08.041

Cited by 68 publications

(30 citation statements)

References 28 publications

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“…Apart from spherical particles, one can also find sorbents with a thin layer of polymer surface coated on a solid support, e.g. glass [13]. As it can be seen in Fig.…”

Section: Methodology Of Preparation Of Porous Molecularly Imprinted Pmentioning

confidence: 99%

Magnetic molecular imprinted polymers as a tool for isolation and purification of biological samples

2015

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Technology of molecularly imprinted polymers (MIP) has become very popular in recent decades. MIPs are primarily used in medical diagnostics, chromatographic separation and solid phase extraction (SPE); also as sensors and catalysts. In recent years there have been reported benefits of combining molecular imprinted polymers with additional features, e.g. magnetic properties, through the build-up of this type of material on magnetite particles (Magnetic Molecularly Imprinted Polymer -MMIP). This method produces a multifunctional material which has high selectivity and the ability to isolate the analyte from biological and environmental samples, allowing effective purification from such interferents as proteins and fats. This developing branch of new materials for the preparation and purification of complex sample matrices is an interesting alternative to materials routinely used to date, particularly with regard to the immunosorbents. This paper summarizes recent reports regarding MMIP preparation and their application for purification and isolation of compounds from biological matrices.

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“…Apart from spherical particles, one can also find sorbents with a thin layer of polymer surface coated on a solid support, e.g. glass [13]. As it can be seen in Fig.…”

Section: Methodology Of Preparation Of Porous Molecularly Imprinted Pmentioning

confidence: 99%

Magnetic molecular imprinted polymers as a tool for isolation and purification of biological samples

2015

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“…However, they are costly, have poor chemical and physical stability, require animals for their production, and are limited in options for some analytes. In recent years, alternatives to antibody-based approaches such as enzyme-substrate reactions, 55 molecularly imprinted polymers, 56 aptamers, 57 and antimicrobial peptides 58 have been developed. DNA hybridization assays 59 provide more sensitive, specific, and rapid detection of target nucleic acids when compared to conventional antibody-based assays.…”

Section: Antibodies Antibody Alternatives and Dnabased Assaysmentioning

confidence: 99%

Development and Applications of Portable Biosensors

2015

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The significance of microfluidics-based and microelectromechanical systems-based biosensors has been widely acknowledged, and many reviews have explored their potential applications in clinical diagnostics, personalized medicine, global health, drug discovery, food safety, and forensics. Because health care costs are increasing, there is an increasing need to remotely monitor the health condition of patients by point-of-care-testing. The demand for biosensors for detection of biological warfare agents has increased, and research is focused on ways of producing small portable devices that would allow fast, accurate, and on-site detection. In the past decade, the demand for rapid and accurate on-site detection of plant disease diagnosis has increased due to emerging pathogens with resistance to pesticides, increased human mobility, and regulations limiting the application of toxic chemicals to prevent spread of diseases. The portability of biosensors for onsite diagnosis is limited due to various issues, including sample preparation techniques, fluid-handling techniques, the limited lifetime of biological reagents, device packaging, integrating electronics for data collection/analysis, and the requirement of external accessories and power. Many microfluidic, electronic, and biological design strategies, such as handling liquids in biosensors without pumps/valves, the application of droplet-based microfluidics, paper-based microfluidic devices, and wireless networking capabilities for data transmission, are being explored.

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“…In recent years, molecularly imprinted polymers (MIPs) have attracted much attention due to their outstanding advantages, such as predetermined recognition ability, stability, relative ease and low cost of preparation, and potential application to a wide range of target molecules [4,5]. Detection applications are employing transduction mechanisms including conductometry [6], amperometry [7][8][9], voltammetry [10,11], Quartz microbalance [12,13] and surface plasmon resonance [14]. Potentiometric technique is also well-known versatile, simple, rapid and inexpensive method for determination of target ion (molecule).…”

Section: Introductionmentioning

confidence: 99%