A Novel Missense Single Nucleotide Polymorphism in the GREM1 Gene is Highly Associated with Higher Reproductive Traits in Awassi Sheep

Imran, Faris S; Al‐Shuhaib, Mohammed Baqur S.; Leprêtre, Frédéric

doi:10.1007/s10528-020-10006-x

Cited by 28 publications

(19 citation statements)

References 38 publications

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“…However, the growth of lambs is affected by many factors, including genetic factors, the birth season, the age of dams, the sequence of birth, the sex of lambs and the weaning period (Jawasreh et al, 2019). Improving sheep's growth traits is the main concern of many researchers, and growth trait is the most important economic factor in animals, which is controlled by several genes (Aljubouri et al, 2020b;Imran et al, 2021). One of the most prevalent sheep breeds in Iraq is Awassi, with 58.2% of prevalence over other breeds, such as Arabi (21.8%) and Karadi (20%) (Aljubouri & Al-Shuhaib, 2021).…”

Section: Introductionmentioning

confidence: 99%

Relationship of some metabolic Hormones with Increased Live Body Weight of Male and Female of Karakul and Awassi Lambs

Aljubouri

Al-Khafaji

Al-Shuhaib

2021

Basrah J. Agric. Sci.

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This study was conducted in the animal field of the Al-Kafeel Company from November 2019 till May 2020 to investigate the possible association between growth hormone (GH) and thyroxine (T4) with the growth traits in Awassi and Karakul sheep. The total number of animals which used in the study was 60 lambs, 28 (13 males and 15 females) from Karakul and 32 (18 males and 14 females) from Awassi. Blood samples were collected at birth, weaning, and six months of age, and both GH and T4 concentrations were measured. Results showed higher values of T4 for Karakul as compared with Awassi at birth and weaning. Karakul breed was also exhibited significantly higher values of GH over Awassi breed only at weaning, while, no significant differences were observed at birth and six months of age. Karakul lambs showed higher weights as compared with Awassi lambs at all studied periods. A highly significant (p < 0.01) positive correlation was observed between T4 concentration and the weight of lambs at most studied periods. Whereas, GH did not exhibit any correlation with growth traits measured in both breeds. The elevated T4 might be one of the reasons for superiority of Karakul over Awassi breed in live body weights. This high correlation between T4 and growth traits could be used in the early selection of lambs to improve the weights of sheep at marketing.

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Section: Introductionmentioning

confidence: 99%

Relationship of some metabolic Hormones with Increased Live Body Weight of Male and Female of Karakul and Awassi Lambs

Aljubouri

Al-Khafaji

Al-Shuhaib

2021

Basrah J. Agric. Sci.

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“…Lipin 1 (LPIN1) is a member of the lipin family of proteins that has an important role in animal and poultry lipid metabolism and its regulation. This gene may have value as a genetic marker for improving some traits such as meat production and carcass [ 113 ]. The HNF4A gene interacted with ENST00000455642 and was highly upregulated, and suppressed by let-7f.…”

Section: Discussionmentioning

confidence: 99%

lncRNA–miRNA–mRNA ceRNA Network Involved in Sheep Prolificacy: An Integrated Approach

Sadeghi

Bahrami

Hasankhani

et al. 2022

Genes

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Understanding the molecular pattern of fertility is considered as an important step in breeding of different species, and despite the high importance of the fertility, little success has been achieved in dissecting the interactome basis of sheep fertility. However, the complex mechanisms associated with prolificacy in sheep have not been fully understood. Therefore, this study aimed to use competitive endogenous RNA (ceRNA) networks to evaluate this trait to better understand the molecular mechanisms responsible for fertility. A competitive endogenous RNA (ceRNA) network of the corpus luteum was constructed between Romanov and Baluchi sheep breeds with either good or poor genetic merit for prolificacy using whole-transcriptome analysis. First, the main list of lncRNAs, miRNAs, and mRNA related to the corpus luteum that alter with the breed were extracted, then miRNA–mRNA and lncRNA–mRNA interactions were predicted, and the ceRNA network was constructed by integrating these interactions with the other gene regulatory networks and the protein–protein interaction (PPI). A total of 264 mRNAs, 14 lncRNAs, and 34 miRNAs were identified by combining the GO and KEGG enrichment analyses. In total, 44, 7, 7, and 6 mRNAs, lncRNAs, miRNAs, and crucial modules, respectively, were disclosed through clustering for the corpus luteum ceRNA network. All these RNAs involved in biological processes, namely proteolysis, actin cytoskeleton organization, immune system process, cell adhesion, cell differentiation, and lipid metabolic process, have an overexpression pattern (Padj < 0.01). This study increases our understanding of the contribution of different breed transcriptomes to phenotypic fertility differences and constructed a ceRNA network in sheep (Ovis aries) to provide insights into further research on the molecular mechanism and identify new biomarkers for genetic improvement.

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“…All PCR products were genotyped according to the protocol of Imran et al [20]. The denaturing-loading buffer (95%, formamide, 0.05% xylene cyanol, and 20 mM EDTA, pH 8) was added to equal volumes for each PCR amplicon.…”

Section: Sscp (Single-strand Conformation Polymorphism)mentioning

confidence: 99%

A novel p.K116Q SNP in the OLR1 gene and its relation to fecundity in Awassi ewes

2022

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A Novel Missense Single Nucleotide Polymorphism in the GREM1 Gene is Highly Associated with Higher Reproductive Traits in Awassi Sheep

Cited by 28 publications

References 38 publications

Relationship of some metabolic Hormones with Increased Live Body Weight of Male and Female of Karakul and Awassi Lambs

Relationship of some metabolic Hormones with Increased Live Body Weight of Male and Female of Karakul and Awassi Lambs

lncRNA–miRNA–mRNA ceRNA Network Involved in Sheep Prolificacy: An Integrated Approach

A novel p.K116Q SNP in the OLR1 gene and its relation to fecundity in Awassi ewes

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