A novel method for preparation of bare and poly(vinylpyrrolidone) coated superparamagnetic iron oxide nanoparticles for biomedical applications

Karimzadeh, Isa; Aghazadeh, Mustafa; Ganjali, Mohammad Reza; Norouzi, Parviz; Shirvani-Arani, Simindokht; Doroudi, Taher; Kolivand, Pirhossein; Marashi, Seyed Ali; Gharailou, Davoud

doi:10.1016/j.matlet.2016.05.048

Cited by 74 publications

(19 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1][2][3][4] However, clinical applications have been disappointing because of the oxidation, acid erosion, severe aggregation, and poor water solubility of SPIONs. [5][6][7][8][9] Increasing efforts are devoted to preparing biostable and biocompatible SPIONs in aqueous media with functional polymeric coatings to avoid these disadvantages. [10][11][12] Conventionally, to stabilize magnetic nanoparticles for medical applications, SPIONs were incorporated into crosslinked polymers to form magnetic nanocomposites due to the excellent watersolubility and colloidal stability of crosslinked polymers, [13][14][15][16] which processed a phase transfer reaction based on exchanging surface surfactants on SPIONs with amphiphilic molecules, such as PEG, 17 dextran, 18 or PEI.…”

Section: Introductionmentioning

confidence: 99%

SPIONs/DOX loaded polymer nanoparticles for MRI detection and efficient cell targeting drug delivery

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

SPIONs/DOX loaded polymer nanoparticles for MRI detection and efficient cell targeting drug delivery

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The band at 3415 is a characteristic of the O-H bond vibration from the residual water that remained in the dried sample. The FTIR spectrum of the IONP shows characteristic bands at 556 cm −1 and 3270 cm −1 that, respectively, correspond to the Fe-O stretching vibration and the O-H stretching bond vibrations from the residual water molecules coordinated to the particle surfaces [38]. The absence of the strong, sharp peaks in the fingerprint region of the IONP spectrum indicates that only trace amounts of surfactant molecules are present [39].…”

Section: Synthesis Of γ-Fe2o3 Maghemite Iron Oxide Nanoparticles (Ionps)mentioning

confidence: 99%

Flavin-Conjugated Iron Oxide Nanoparticles as Enzyme-Inspired Photocatalysts for Azo Dye Degradation

2020

View full text Add to dashboard Cite

In this work, a new photocatalytic system consisting of iron oxide nanoparticles (IONPs), coated with a catechol-flavin conjugate (DAFL), is synthesized and explored for use in water remediation. In order to test the efficiency of the catalyst, the photodegradation of amaranth (AMT), an azo dye water pollutant, was performed under aerobic and anaerobic conditions, using either ethylenediaminetetraacetic acid (EDTA) or 2-(N-morpholino)ethanesulfonic acid (MES) as electron donors. Depending on the conditions, either dye photoreduction or photooxidation were observed, indicating that flavin-coated iron-oxide nanoparticles can be used as a versatile enzyme-inspired photocatalysts.

show abstract

“…A variety of other polymers or copolymers are also used for the encapsulation of MNPs, including polyvinyl alcohol (PVA) [90,91], polylactic acid/poly(lactic-co-glycolic acid) (PLA/PLGA) [92], and polyvinylpyrrolidone (PVP) [93][94][95][96]. These polymers have different properties and can influence the properties of MNPs, such as the surface charge, function, dispersibility, and magnetic properties, in different ways.…”

Section: Organic Coating Materialsmentioning

confidence: 99%

Magnetic drug delivery systems

Liu

Yang

et al. 2017

Sci. China Mater.

View full text Add to dashboard Cite

There has been unprecedented progress in the development of biomedical nanotechnology and nanomaterials over the past few decades, and nanoparticle-based drug delivery systems (DDSs) have great potential for clinical applications. Among these, magnetic drug delivery systems (MDDSs) based on magnetic nanoparticles (MNPs) are attracting increasing attention owing to their favorable biocompatibility and excellent multifunctional loading capability. MDDSs primarily have a solid core of superparamagnetic maghemite (γ-Fe2O3) or magnetite (Fe3O4) nanoparticles ranging in size from 10 to 100 nm. Their surface can be functionalized by organic and/or inorganic modification. Further conjugation with targeting ligands, drug loading, and MNP assembly can provide complex magnetic delivery systems with improved targeting efficacy and reduced toxicity. Owing to their sensitive response to external magnetic fields, MNPs and their assemblies have been developed as novel smart delivery systems. In this review, we first summarize the basic physicochemical and magnetic properties of desirable MDDSs that fulfill the requirements for specific clinical applications. Secondly, we discuss the surface modifications and functionalization issues that arise when designing elaborate MDDSs for future clinical uses. Finally, we highlight recent progress in the design and fabrication of MNPs, magnetic assemblies, and magnetic microbubbles and liposomes as MDDSs for cancer diagnosis and therapy. Recently, researchers have focused on enhanced targeting efficacy and theranostics by applying step-by-step sequential treatment, and by magnetically modulating dosing regimens, which are the current challenges for clinical applications.

show abstract

A novel method for preparation of bare and poly(vinylpyrrolidone) coated superparamagnetic iron oxide nanoparticles for biomedical applications

Cited by 74 publications

References 15 publications

SPIONs/DOX loaded polymer nanoparticles for MRI detection and efficient cell targeting drug delivery

SPIONs/DOX loaded polymer nanoparticles for MRI detection and efficient cell targeting drug delivery

Flavin-Conjugated Iron Oxide Nanoparticles as Enzyme-Inspired Photocatalysts for Azo Dye Degradation

Magnetic drug delivery systems

Contact Info

Product

Resources

About