2020
DOI: 10.3389/fnins.2020.561556
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A Novel Method for High-Dimensional Anatomical Mapping of Extra-Axial Cerebrospinal Fluid: Application to the Infant Brain

Abstract: Cerebrospinal fluid (CSF) plays an essential role in early postnatal brain development. Extra-axial CSF (EA-CSF) volume, which is characterized by CSF in the subarachnoid space surrounding the brain, is a promising marker in the early detection of young children at risk for neurodevelopmental disorders. Previous studies have focused on global EA-CSF volume across the entire dorsal extent of the brain, and not regionally-specific EA-CSF measurements, because no tools were previously available for extracting loc… Show more

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Cited by 2 publications
(1 citation statement)
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“…Unfortunately, the use of a ventral boundary at the anterior commissure-posterior commissure line leaves out a large quantity of extra-axial CSF, including CSF surrounding the temporal and occipital lobes. However, we note that a pipeline using a localized, cortical surface analysis is currently in development and described by Mostapha and colleagues, although the pipeline has not yet been made publicly available ( Mostapha et al, 2020 ). This new pipeline may resolve these concerns and allow for future investigation into total extra-axial CSF volume and its relationship to autism.…”
Section: Discussionmentioning
confidence: 99%
“…Unfortunately, the use of a ventral boundary at the anterior commissure-posterior commissure line leaves out a large quantity of extra-axial CSF, including CSF surrounding the temporal and occipital lobes. However, we note that a pipeline using a localized, cortical surface analysis is currently in development and described by Mostapha and colleagues, although the pipeline has not yet been made publicly available ( Mostapha et al, 2020 ). This new pipeline may resolve these concerns and allow for future investigation into total extra-axial CSF volume and its relationship to autism.…”
Section: Discussionmentioning
confidence: 99%