“…Although there is an in vitro study that reports reduced wear rates of ceramic-on-metal compared with metal-on-metal pairings [6], it does not consider in vivo phenomena like microseparation or third body particles (not observed in our patient). Apparently, microseparation affects ceramic-on-ceramic bearing surfaces [3,7] but does not occur in metal-on-metal THA [8].…”
A 51-year-old woman came to our clinic 6 months after a right total hip arthroplasty. She had noticed a slowly growing mass in the proximal thigh and referred progressive pain in the right groin. Plain radiography revealed premature acetabular cup aseptic loosening, and in the computed tomography study, a 14-cm-diameter mass was observed. Revision surgery was performed, showing a metal-on-ceramic bearing surface. The histologic analysis of surrounding tissues was reported as massive metallosis. Although occasionally chosen for primary or revision hip arthroplasty, there is little information available about the in vivo wear behavior of this combination. This important fact should be taken into account before considering such a surface alternative.
“…Although there is an in vitro study that reports reduced wear rates of ceramic-on-metal compared with metal-on-metal pairings [6], it does not consider in vivo phenomena like microseparation or third body particles (not observed in our patient). Apparently, microseparation affects ceramic-on-ceramic bearing surfaces [3,7] but does not occur in metal-on-metal THA [8].…”
A 51-year-old woman came to our clinic 6 months after a right total hip arthroplasty. She had noticed a slowly growing mass in the proximal thigh and referred progressive pain in the right groin. Plain radiography revealed premature acetabular cup aseptic loosening, and in the computed tomography study, a 14-cm-diameter mass was observed. Revision surgery was performed, showing a metal-on-ceramic bearing surface. The histologic analysis of surrounding tissues was reported as massive metallosis. Although occasionally chosen for primary or revision hip arthroplasty, there is little information available about the in vivo wear behavior of this combination. This important fact should be taken into account before considering such a surface alternative.
“…A ceramic-on-metal (CoM) bearing for THA has been studied in hip simulators and clinically at 12 months [1,2,4,5,8,10,11,[19][20][21][22][23]. The CoM bearing has potential advantages over other bearing surfaces.…”
Background Hard-on-hard bearings for total hip arthroplasty continue to warrant analysis even though crosslinked polyethylene is performing very well. Ceramicon-metal (CoM) has low in vitro wear and did well in an early clinical trial. We report on a prospective, randomized, multicenter investigational device trial comparing CoM with metal-on-metal (MoM). Questions/purposes (1) Is there a difference in the number or type of revisions comparing CoM with MoM? (2) Are cobalt and chromium metal levels different for CoM and MoM THA? Methods Between
“…This may explain why models developed for conventional UHMWPE to evaluate the biologic response to particles have predicted higher osteolytic potential for crosslinked PEs [16,26] rather than the lower potential actually observed. To date, methods developed to assess the biologic reactivity to wear debris have considered the sizes, compositions, and surface areas of the particles [22,30,33,44,45].…”
Background Numerous studies indicate highly crosslinked polyethylenes reduce the wear debris volume generated by hip arthroplasty acetabular liners. This, in turns, requires new methods to isolate and characterize them. Questions/purposes We describe a method for extracting polyethylene wear particles from bovine serum typically used in wear tests and for characterizing their size, distribution, and morphology.Methods Serum proteins were completely digested using an optimized enzymatic digestion method that prevented the loss of the smallest particles and minimized their clumping. Density-gradient ultracentrifugation was designed to remove contaminants and recover the particles without filtration, depositing them directly onto a silicon wafer. This provided uniform distribution of the particles and high contrast against the background, facilitating accurate, automated, morphometric image analysis. The accuracy and precision of the new protocol were assessed by recovering and characterizing particles from wear tests of three types of polyethylene acetabular cups (no crosslinking and 5 Mrads and 7.5 Mrads of gamma irradiation crosslinking). Results The new method demonstrated important differences in the particle size distributions and morphologic parameters among the three types of polyethylene that could not be detected using prior isolation methods. Conclusion The new protocol overcomes a number of limitations, such as loss of nanometer-sized particles and artifactual clumping, among others. Clinical Relevance The analysis of polyethylene wear particles produced in joint simulator wear tests of prosthetic joints is a key tool to identify the wear mechanisms that produce the particles and predict and evaluate their effects on periprosthetic tissues.
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