A Novel lncRNA Mediates the Delayed Tooth Eruption of Cleidocranial Dysplasia

Xin, Yuejiao; Liu, Yang; Li, Jie; Liu, Dandan; Zhang, Chenying; Wang, Yixiang; Zheng, Shuguo

doi:10.3390/cells11172729

Cited by 6 publications

(4 citation statements)

References 46 publications

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“…The impaired osteogenic potential of SHED from patients with CCD. have mainly focused on the mechanism of dental replacement (Qin et al, 2019;Xin et al, 2022;Zeng et al, 2022). However, the clinical features of severe caries and early tooth loss, which also influence the oral and mental health of individuals with CCD, have been received little attention.…”

Section: Discussionmentioning

confidence: 99%

Amyloid-mediated remineralization for tooth hypoplasia of cleidocranial dysplasia

Guo

Yang²,

Liu³

et al. 2023

Front. Cell. Infect. Microbiol.

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IntroductionCleidocranial dysplasia (CCD) is an autosomal-dominant, heritable skeletal and dental disease, involving hypoplastic clavicles, defective ossification of the anterior fontanelle, dentin and enamel hypoplasia, and supernumerary teeth, which can seriously affect the oral and mental health of patients. Amyloid-like protein aggregation, which is established by lysozyme conjugated with polyethylene glycol (Lyso-PEG), forms a mineralized nanofilm layer on a healthy enamel surface. However, whether it can form a remineralization layer in dental tissues from CCD remains unclear.MethodsThis study evaluated deciduous teeth from healthy individuals and a patient with CCD. Because pulp and dentin are functionally closely related, stem cells from human exfoliated deciduous teeth (SHED) from CCD patients and healthy individuals were collected to compare their biological properties.ResultsThe results found that deciduous teeth from patients with CCD exhibited dentin hypoplasia. In addition, the proliferative ability and osteogenic potential of SHED from patients with CCD were lower than those of control individuals. Finally, Lyso-PEG was applied to dentin from the CCD and control groups, showing a similar remineralization-induced effect on the dentin surfaces of the two groups.ConclusionThese results extend our understanding of the dentin and SHED of patients with CCD, exhibiting good caries-preventive capacity and good biocompatibility of Lyso-PEG, thus providing a novel dental therapy for CCD and patients with tooth hypoplasia.

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Section: Discussionmentioning

confidence: 99%

Amyloid-mediated remineralization for tooth hypoplasia of cleidocranial dysplasia

Guo

Yang²,

Liu³

et al. 2023

Front. Cell. Infect. Microbiol.

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“…Arid et al reported that rs9594738 in RANKL may be related with delayed permanent tooth emergence with the odds ratio of 1.71 [28]. Also, osteoclast dysfunction mediated through osteoclast-specifi c lncRNA seems also to be a factor associated with delayed tooth eruption [29]. Systematic review has approved the role of genetic factors on delayed tooth eruption development based on results of longitudinal studies, while also highlighted the need in further genome-wide association studies to clarify cause-effect relationship [30].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of delayed tooth eruption of permanent maxillary anterior teeth among Ukrainian children: retrospective radiographic study using CBCT data

Dakhno

Malashenko

Lykhota

2023

UDJ

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Background. Tooth eruption is a complex, multi-staged, and well-regulated biological and age specific process that can be affected and influenced by many systemic and local factors. The deviation more than ±2SD from the established norm of tooth eruption terms, while also taking account racial, ethnic, and gender factors, is important for the clinician. Objective. To estimate the prevalence of delayed tooth eruption (DTE) of permanent maxillary anterior teeth among Ukrainian children sample and to investigate the epidemiology distribution of delayed eruption cases according to their causes based on CBCT data. Materials and Methods. Cone Beam Computed Tomography (CBCT) data sets of 684 children (304 boys and 380 girls) aged 7–14 years old, who previously have sought for orthodontic diagnostics in Central Laboratory Diagnosis of the Head (CLDH), were collected and examined to detect any delayed eruption of the permanent maxillary anterior teeth. Signs of delayed eruption were identified considering tooth developmental stages, relationships between the chronologic age and dental developmental age, eruption sequence. Results. The total prevalence of delayed tooth eruption of permanent maxillary anterior teeth among the 684 children was 42.84%. 293 children (155 boys and 138 girls) had at least one impacted or retained tooth. The maxillary canines the most frequently demonstrated signs of delayed eruption and compiled 30.7% of all examined cases and 71.67% of all delayed eruption cases, followed by the lateral incisors of the maxilla – 6.58% and 15.36% respectively, and the central incisors – 5.56% and 12.97% respectively. Loss of space in dental arch and the ectopic eruption pathway were the most causative factor of delayed eruption of permanent maxillary anterior teeth. Conclusions. Delayed tooth eruption of permanent maxillary anterior teeth is frequently seen in everyday orthodontic practice and requires a multidisciplinary approach of diagnostics to avoid many treatment-related complications. CBCT data is essential for timely diagnostics of DTE and primary for the causative factors identification in order to provide optimal and effective management plan for each patient.

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“…In addition, miR-31 is downregulated in the gingival tissue of individuals with skeletal Class I occlusion, and this downregulation is associated with an increase in the expression of the target geneTWIST1, which is involved in regulating craniofacial development [56]. Further, miR-124 was found to be downregulated in the gingival tissue of individuals with skeletal Class I occlusion, and this downregulation is associated with an increase in the expression of the target geneDlx5, which is involved in the regulation of tooth development [57].…”

Section: Rna Alterations In Skeletal Class I Occlusionmentioning

confidence: 99%

Narrating the Genetic Landscape of Human Class I Occlusion: A Perspective-Infused Review

Lone,

Zohud,

Midlej

et al. 2023

JPM

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This review examines a prevalent condition with multifaceted etiology encompassing genetic, environmental, and oral behavioral factors. It stands as a significant ailment impacting oral functionality, aesthetics, and quality of life. Longitudinal studies indicate that malocclusion in primary dentition may progress to permanent malocclusion. Recognizing and managing malocclusion in primary dentition is gaining prominence. The World Health Organization ranks malocclusions as the third most widespread oral health issue globally. Angle’s classification system is widely used to categorize malocclusions, with Class I occlusion considered the norm. However, its prevalence varies across populations due to genetic and examination disparities. Genetic factors, including variants in genes like MSX1, PAX9, and AXIN2, have been associated with an increased risk of Class I occlusion. This review aims to provide a comprehensive overview of clinical strategies for managing Class I occlusion and consolidate genetic insights from both human and murine populations. Additionally, genomic relationships among craniofacial genes will be assessed in individuals with Class I occlusion, along with a murine model, shedding light on phenotype–genotype associations of clinical relevance. The prevalence of Class I occlusion, its impact, and treatment approaches will be discussed, emphasizing the importance of early intervention. Additionally, the role of RNA alterations in skeletal Class I occlusion will be explored, focusing on variations in expression or structure that influence craniofacial development. Mouse models will be highlighted as crucial tools for investigating mandible size and prognathism and conducting QTL analysis to gain deeper genetic insights. This review amalgamates cellular, molecular, and clinical trait data to unravel correlations between malocclusion and Class I phenotypes.

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A Novel lncRNA Mediates the Delayed Tooth Eruption of Cleidocranial Dysplasia

Cited by 6 publications

References 46 publications

Amyloid-mediated remineralization for tooth hypoplasia of cleidocranial dysplasia

Amyloid-mediated remineralization for tooth hypoplasia of cleidocranial dysplasia

Prevalence of delayed tooth eruption of permanent maxillary anterior teeth among Ukrainian children: retrospective radiographic study using CBCT data

Narrating the Genetic Landscape of Human Class I Occlusion: A Perspective-Infused Review

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