A novel LC–MS/MS assay for methylprednisolone in human plasma and its pharmacokinetic application

Siddiraju, Sridhar; Prasanth, Mercy Lazar Lal; Sirisha, Tadiboyina

doi:10.1016/j.ajps.2015.06.005

Cited by 10 publications

(3 citation statements)

References 15 publications

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“…Due to their reliability, the proposed tool and method are a good addition to the most reliable tools and methods developed to date for pharmaceutical analysis. [33][34][35][36] Compared with the chromatographic methods developed earlier, 11 the proposed method is having a higher reliability, wider linear concentration ranges, and lower limit of quantification.…”

Section: Determination Of Methylprednisolone In Tablets and Surface W...mentioning

confidence: 98%

“…These include highperformance liquid chromatography (HPLC), ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS), liquid chromatography-tandem mass spectrometry (LC-MS/MS), immunochromatographic assay (ICA), liquid chromatography-electrospray-tandem mass spectrometric (LC-ESI-MS/MS). [8][9][10][11][12][13][14] These techniques are robust and yield accurate results, however, they come with some disadvantages, namely expensive equipment that requires specialized personnel supervision, a high solvent consumption rate, and time-consuming sample preparation procedures. Research efforts have been directed toward sensor-based electrochemical methods to counteract these drawbacks and provide an alternative to traditional methods.…”

mentioning

confidence: 99%

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Multimode Detection Platform Based on 3D Integrated Sensor for Fast On-Site Assay of Methylprednisolone in Its Pharmaceutical Formulation and Surface Water Samples

Staden

Tuchiu

Staden

et al. 2023

J. Electrochem. Soc.

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A portable electrochemical platform that detects methylprednisolone in two switchable modes has been developed. Both selected modes, square wave voltammetry and stochastic, provide qualitative and quantitative analysis of the analyte. Under optimal conditions, the platform recorded the following linear concentration ranges, between 1.00 and 1.00 × 10¬3 µmol L‒1 when using the square wave voltammetry mode, and a much wider range between 1.00 × 10¬‒9 and 1.00 × 10¬4 µmol L‒1 when using the stochastic mode. The limits of quantification recorded were: 1.00 fmol L-1 for the stochastic mode, and 1.00 µmol L-1 for the square wave voltammetry mode. The developed platform was successfully applied for the assay of methylprednisolone in real samples (pharmaceutical dosage form and surface water), when recoveries higher than 90.00% were obtained.

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Section: Determination Of Methylprednisolone In Tablets and Surface W...mentioning

confidence: 98%

mentioning

confidence: 99%

Multimode Detection Platform Based on 3D Integrated Sensor for Fast On-Site Assay of Methylprednisolone in Its Pharmaceutical Formulation and Surface Water Samples

Staden

Tuchiu

Staden

et al. 2023

J. Electrochem. Soc.

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“…Moreover, there is evidence that MPA may behave less toxic . Several analytical methods have been introduced for the determination of MPA in pharmaceutical preparations and body fluids, such as UV‐Vis spectrophotometry, HPLC, and LC‐ESI MS/MS .…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive separation of methylprednisolone acetate using a photoresponsive molecularly imprinted polymer incorporated polyester dendrimer based on magnetic nanoparticles

Baimani

Azar

Husain

et al. 2019

J of Separation Science

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We developed an approach for the use of polyester dendrimer during the imprinting process to raise the number of recognized sites in the polymer matrix and improve its identification ability. Photoresponsive molecularly imprinted polymers were synthesized on modified magnetic nanoparticles involving polyester dendrimer which uses the reactivity between allyl glycidyl ether and acrylic acid for the high‐yielding assembly by surface polymerization. The photoresponsive molecularly imprinted polymers were constructed using methylprednisoloneacetate as the template, water‐soluble azobenzene involving 5‐[(4, 3‐(methacryloyloxy) phenyl) diazenyl] dihydroxy aniline as the novel functional monomer, and ethylene glycol dimethacrylate as the cross‐linker. Through the evaluation of a series of features of spectroscopic and nano‐structural, this sorbent showed excellent selective adsorption, recognition for the template, and provided a highly selective and sensitive strategy for determining the methylprednisoloneacetate in real and pharmaceutical samples. In addition, this sorbent according to good photo‐responsive features and specific affinity to methylprednisoloneacetate with high recognition ability, represented higher binding capacity, a more extensive specific area, and faster mass transfer rate than its corresponding surface molecularly imprinted polymer.

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Electrochemical sensor for determination of methylprednisolone as an anabolic steroid used in doping

Liu¹,

Peng²,

Wu³

et al. 2023

International Journal of Electrochemical Science

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A novel LC–MS/MS assay for methylprednisolone in human plasma and its pharmacokinetic application

Cited by 10 publications

References 15 publications

Multimode Detection Platform Based on 3D Integrated Sensor for Fast On-Site Assay of Methylprednisolone in Its Pharmaceutical Formulation and Surface Water Samples

Multimode Detection Platform Based on 3D Integrated Sensor for Fast On-Site Assay of Methylprednisolone in Its Pharmaceutical Formulation and Surface Water Samples

Ultrasensitive separation of methylprednisolone acetate using a photoresponsive molecularly imprinted polymer incorporated polyester dendrimer based on magnetic nanoparticles

Electrochemical sensor for determination of methylprednisolone as an anabolic steroid used in doping

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