A Novel Interplay Between Irisin and PTH: From Basic Studies to Clinical Evidence in Hyperparathyroidism

Palermo, Andrea; Sanesi, Lorenzo; Colaianni, Graziana; Tabacco, Gaia; Naciu, Anda Mihaela; Cesareo, Roberto; Pedone, Claudio; Lelli, Diana; Brunetti, Giacomina; Mori, Giorgio; Colucci, Silvia; Manfrini, Silvia; Napoli, Nicola; Grano, Maria

doi:10.1210/jc.2018-02216

Cited by 41 publications

(39 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent research investigated the relationship between irisin and PTH both by "in vitro experiments" and by clinical evaluation in a cohort of patients with primary hyperparathyroidism. 58 As a result, the authors showed that the two hormones inhibit one Figure 2 Independent variables associated with circulating irisin levels in patients with controlled CD at multivariate analysis. Abbreviations: WC, waist circumference; UFC, urinary free cortisol; CRT, chair rising test; BF%, body fat percentage.…”

Section: Discussionmentioning

confidence: 99%

<p>Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease</p>

Guarnotta

Prinzi

Pitrone

et al. 2020

DMSO

View full text Add to dashboard Cite

To evaluate circulating irisin levels in patients with active and controlled Cushing's disease (CD). Design: Forty-four patients with CD evaluated during the active phase and after 12 months of biochemical remission and 40 controls were recruited. Methods: Phenotypic, anthropometric, hormonal and metabolic parameters, including insulin sensitivity estimation by homeostatic model of insulin resistance, Matsuda index and oral disposition index and circulating irisin levels were evaluated. Results: Patients with active CD showed lower irisin levels compared to controls (p<0.001) and controlled CD (p<0.001). The independent variables significantly associated with irisin were waist circumference (WC) (p=0.025), body fat percentage (BF%) (p=0.009), PTH (p=0.007) and chair rising test (CRT) (p<0.001) in active CD and WC (p=0.013), BF% (p=0.014), PTH (p=0.038), CRT (p=0.029) and urinary-free cortisol (p<0.001) in controlled CD. Conclusion: Circulating irisin levels tend to be lower in patients with active CD compared to those with controlled CD and controls. They are strongly associated with osteosarcopenia and central obesity in CD and therefore may be a possible marker of diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

<p>Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease</p>

Guarnotta

Prinzi

Pitrone

et al. 2020

DMSO

View full text Add to dashboard Cite

show abstract

“…In the present study, we found that serum irisin levels were at a few μg/ml. However, circulating irisin levels have been reported at μg/ml [3,20], ng/ml [21,22], and even pg/ml [23,24] levels in different studies. In most studies, irisin levels were measured by ELISA.…”

Section: Disease Markersmentioning

confidence: 96%

Serum Irisin Predicts Posthepatectomy Complications in Patients with Hepatocellular Carcinoma

Jia

Ren

et al. 2019

Disease Markers

View full text Add to dashboard Cite

Background. Hepatectomy remains one of the most effective treatments for patients with hepatocellular carcinoma (HCC); however, it can lead to serious complications. Irisin, a key regulator of energy metabolism, is secreted into the circulation by shedding of the extracellular portion of the fibronectin type III domain-containing 5 (FNDC5). We have shown that irisin administration alleviates liver ischemia-reperfusion injury in mice. However, the role of preoperative irisin levels in HCC patients who underwent hepatectomy remained unknown. The purpose of this study was to determine how irisin expression changes in HCC and to explore the relationship between preoperative serum irisin levels and complications after hepatectomy. Methods. FNDC5/irisin expression data in HCC were extracted from The Cancer Genome Atlas (TCGA) dataset. A total of 219 participants, including 102 healthy controls and 117 HCC patients, were recruited in this study. All HCC patients underwent hepatectomy at the First Affiliated Hospital of the Xi’an Jiaotong University. Preoperative serum irisin levels were measured by ELISA. Postoperative complications were assessed using the comprehensive complication index (CCI) score. The Pearson rank correlation coefficient was computed to assess the correlation between preoperative serum irisin levels and postoperative CCI scores. Results. In TCGA dataset, FNDC5/irisin expression was downregulated in HCC tissues (P<0.001). Similarly, serum irisin levels were decreased in HCC patients (P<0.001). Low preoperative serum irisin levels were significantly correlated with high CCI scores after hepatectomy. Conclusions. Irisin may be a novel serum biomarker in the diagnosis of HCC and a predictor of complications after hepatectomy.

show abstract

“…It acts on adipose tissue by inducing browning of white adipocytes, on bone by increasing bone mineral density, and on muscle. Palermo et al [ 237 ] recently demonstrated the existence of crosstalk between irisin and PTH. Treatment with PTH 1–34 induced downregulation of FNDC5 transcripts and proteins in myotubes, while recombinant irisin exposure reduced PTHR1 mRNA expression in osteoblasts.…”

Section: Direct and Indirect Effects Of Pth On Skeletal Muscle Masmentioning

confidence: 99%

“…Treatment with PTH 1–34 induced downregulation of FNDC5 transcripts and proteins in myotubes, while recombinant irisin exposure reduced PTHR1 mRNA expression in osteoblasts. Moreover, circulating irisin levels were lower in postmenopausal PHPT patients compared to controls [ 237 , 238 ].…”

Section: Direct and Indirect Effects Of Pth On Skeletal Muscle Masmentioning

confidence: 99%

Physical Activity-Dependent Regulation of Parathyroid Hormone and Calcium-Phosphorous Metabolism

Lombardi

Ziemann²,

Banfi

et al. 2020

IJMS

View full text Add to dashboard Cite

Exercise perturbs homeostasis, alters the levels of circulating mediators and hormones, and increases the demand by skeletal muscles and other vital organs for energy substrates. Exercise also affects bone and mineral metabolism, particularly calcium and phosphate, both of which are essential for muscle contraction, neuromuscular signaling, biosynthesis of adenosine triphosphate (ATP), and other energy substrates. Parathyroid hormone (PTH) is involved in the regulation of calcium and phosphate homeostasis. Understanding the effects of exercise on PTH secretion is fundamental for appreciating how the body adapts to exercise. Altered PTH metabolism underlies hyperparathyroidism and hypoparathyroidism, the complications of which affect the organs involved in calcium and phosphorous metabolism (bone and kidney) and other body systems as well. Exercise affects PTH expression and secretion by altering the circulating levels of calcium and phosphate. In turn, PTH responds directly to exercise and exercise-induced myokines. Here, we review the main concepts of the regulation of PTH expression and secretion under physiological conditions, in acute and chronic exercise, and in relation to PTH-related disorders.

show abstract

A Novel Interplay Between Irisin and PTH: From Basic Studies to Clinical Evidence in Hyperparathyroidism

Cited by 41 publications

References 22 publications

<p>Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease</p>

<p>Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease</p>

Serum Irisin Predicts Posthepatectomy Complications in Patients with Hepatocellular Carcinoma

Physical Activity-Dependent Regulation of Parathyroid Hormone and Calcium-Phosphorous Metabolism

Contact Info

Product

Resources

About