A novel insight for high-rate and low-efficiency glucose metabolism in depression through stable isotope-resolved metabolomics in CUMS-induced rats

Tian, Jun-Sheng; Zhao, Yun-hao; Linghu, Ting; Wu, Wen-ze; Wang, Xianxian; Ji, Cui; Zhao, Wei-di; Han, Ying; Qin, Xuemei

doi:10.1016/j.jad.2023.03.061

Cited by 8 publications

(3 citation statements)

References 37 publications

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“…Previous studies have demonstrated the inhibition of the tricarboxylic acid (TCA) cycle in mice exposed to chronic social defeat stress (CSDS) and patients experiencing first‐episode depression 56 . Also, the depression‐like behavior was associated with significant alternations of both glycolysis and TCA cycle in different brain regions 57,58 . Glucose served as the primary energy source for the developmental brain, facilitating proper neurotransmitter synthesis and function, particularly with regard to glutamate and γ‐aminobutyric acid (GABA), as well as appropriate nicotinamide adenine dinucleotide phosphate oxidase (NADPH) levels.…”

Section: Discussionmentioning

confidence: 99%

“… 56 Also, the depression‐like behavior was associated with significant alternations of both glycolysis and TCA cycle in different brain regions. 57 , 58 Glucose served as the primary energy source for the developmental brain, facilitating proper neurotransmitter synthesis and function, particularly with regard to glutamate and γ‐aminobutyric acid (GABA), as well as appropriate nicotinamide adenine dinucleotide phosphate oxidase (NADPH) levels. The olfactory bulbectomized rat models of depression demonstrated a reduction in overall cerebral glucose utilization, 59 while rats exposed to CUMS exhibited insulin resistance specifically within the arcuate nucleus of the hypothalamus.…”

Section: Discussionmentioning

confidence: 99%

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Transcutaneous auricular vagus nerve stimulation ameliorates adolescent depressive‐ and anxiety‐like behaviors via hippocampus glycolysis and inflammation response

Sun,

Ma,

et al. 2024

CNS Neurosci Ther

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BackgroundTranscutaneous auricular vagus nerve stimulation (taVNS) is a crucial neuromodulation therapy for depression, yet its molecular mechanism remains unclear. Here, we aim to unveil the underlying mechanisms of antidepression by systematically evaluating the change of gene expression in different brain regions (i.e., hippocampus, anterior cingulate cortex, and medial prefrontal cortex).MethodsThe adolescent depression rat model was established by chronic unpredictable mild stress (CUMS), followed by the taVNS treatment for 3 weeks. The open field test (OFT), forced swimming test (FST), elevated plus maze test (EPM), and new object recognition (NOR) test were used to evaluate depressive‐ and anxiety‐like behaviors. Gene expression analysis of three brain regions was conducted by RNA sequencing (RNA‐seq) and further bioinformatics methods.ResultsThe depressive‐ and anxiety‐like behaviors in CUMS‐exposed rats were manifested by decreased spontaneous locomotor activity of OFT, increased immobility time of FST, increased entries and time in the closed arms of EPM, and decreased new object index of NOR. Furthermore, CUMS exposure also led to alterations in gene expression within the hippocampus (HIP), anterior cingulate cortex (ACC), and medial prefrontal cortex (mPFC), suggesting a potential link between adolescent stress and pathological changes within these brain regions. TaVNS could significantly ameliorate depressive‐ and anxiety‐like behaviors. Its effects on these three brain regions were found related to regulation of the metabolism, and there were some brain region‐specific findings. Compared with ACC and mPFC, taVNS has a more concrete effect on HIP by regulating the inflammation response and glycolysis.ConclusiontaVNS is capable of ameliorating adolescent depressive‐ and anxiety‐like behaviors by regulating plenty of genes in the three brain regions. Suppressed level of inflammatory response and enhanced glycolysis manifests the dominant role of taVNS in HIP, which provides a theoretical foundation and data support for the molecular mechanism of antidepression by taVNS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Transcutaneous auricular vagus nerve stimulation ameliorates adolescent depressive‐ and anxiety‐like behaviors via hippocampus glycolysis and inflammation response

Sun,

Ma,

et al. 2024

CNS Neurosci Ther

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“…Acylcarnitine profiles also help to distinguish different phenotypic subtypes of MDD, such as core depression, anxious depression, and neurovegetative symptoms of melancholia [81]. Given that glycogen is the main energy source for most higher organisms, Qin's group used stable isotope-resolved metabolomics with a 13 C 6 -glucose tracer to reveal the blockage of the tricarboxylic acid cycle and abnormal activation of gluconeogenesis in rats with CUMS and in corticosteroid-induced PC12 cells [82][83][84][85][86].…”

Section: Energy Metabolismmentioning

confidence: 99%

Recent Progress in Mass Spectrometry-Based Metabolomics in Major Depressive Disorder Research

Liu,

Ma,

et al. 2023

Molecules

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Major depressive disorder (MDD) is a serious mental illness with a heavy social burden, but its underlying molecular mechanisms remain unclear. Mass spectrometry (MS)-based metabolomics is providing new insights into the heterogeneous pathophysiology, diagnosis, treatment, and prognosis of MDD by revealing multi-parametric biomarker signatures at the metabolite level. In this comprehensive review, recent developments of MS-based metabolomics in MDD research are summarized from the perspective of analytical platforms (liquid chromatography-MS, gas chromatography-MS, supercritical fluid chromatography-MS, etc.), strategies (untargeted, targeted, and pseudotargeted metabolomics), key metabolite changes (monoamine neurotransmitters, amino acids, lipids, etc.), and antidepressant treatments (both western and traditional Chinese medicines). Depression sub-phenotypes, comorbid depression, and multi-omics approaches are also highlighted to stimulate further advances in MS-based metabolomics in the field of MDD research.

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A Novel Strategy for the Development of Functional Foods to Improve Energy Metabolism Disorders: Stable Isotope-Resolved Metabolomics

Meng

et al. 2023

Food Bioprocess Technol

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A novel insight for high-rate and low-efficiency glucose metabolism in depression through stable isotope-resolved metabolomics in CUMS-induced rats

Cited by 8 publications

References 37 publications

Transcutaneous auricular vagus nerve stimulation ameliorates adolescent depressive‐ and anxiety‐like behaviors via hippocampus glycolysis and inflammation response

Transcutaneous auricular vagus nerve stimulation ameliorates adolescent depressive‐ and anxiety‐like behaviors via hippocampus glycolysis and inflammation response

Recent Progress in Mass Spectrometry-Based Metabolomics in Major Depressive Disorder Research

A Novel Strategy for the Development of Functional Foods to Improve Energy Metabolism Disorders: Stable Isotope-Resolved Metabolomics

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