A novel injectable, cohesive and toughened Si-HPMC (silanized-hydroxypropyl methylcellulose) composite calcium phosphate cement for bone substitution

Liu, Weizhen; Zhang, Jingtao; Réthoré, Gildas; Khairoun, Khalid; Pilet, Paul; Tancret, Franck; Bouler, Jean‐Michel; Weiss, Pierre

doi:10.1016/j.actbio.2014.03.009

Cited by 75 publications

(57 citation statements)

References 60 publications

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“…CPCs have good biocompatibility, are self-setting and possess osteoconduction properties [2][3][4][5]. Specifically, CPCs can be molded or injected and set in situ to closely adapt to complex shapes caused by bone defects [6][7][8]. In 1986, the first calcium phosphate cement was developed and consisted of tetracalcium phosphate and dicalcium phosphate anhydrous.…”

Section: Introductionmentioning

confidence: 99%

Effects of adding resorbable chitosan microspheres to calcium phosphate cements for bone regeneration

Meng

Dong

Wen

et al. 2015

Materials Science and Engineering: C

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Section: Introductionmentioning

confidence: 99%

Effects of adding resorbable chitosan microspheres to calcium phosphate cements for bone regeneration

Meng

Dong

Wen

et al. 2015

Materials Science and Engineering: C

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“…2,3 Several additives, especially in the form of natural polymers, have been used to correct the physical and biological properties of CPCs. [4][5][6][7] Gelatin is a partially hydrolyzed form of collagen, which is a natural component of bone matrix. Gelatin, in its various physical forms, has been widely used in bone-related composites to enhance the physical and biological properties.…”

mentioning

confidence: 99%

Blooming gelatin: an individual additive for enhancing nanoapatite precipitation, physical properties, and osteoblastic responses of nanostructured macroporous calcium phosphate bone cements

Orshesh¹,

Hesaraki²,

Khanlarkhani³

2017

IJN

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In recent years, there has been a great interest in using natural polymers in the composition of calcium phosphate bone cements to enhance their physical, mechanical, and biological performance. Gelatin is a partially hydrolyzed form of collagen, a natural component of bone matrix. In this study, the effect of blooming gelatin on the nanohydroxyapatite precipitation, physical and mechanical properties, and cellular responses of a calcium phosphate bone cement (CPC) was investigated. Various concentrations of blooming gelatin (2, 5, and 8 wt.%) were used as the cement liquid and an equimolar mixture of tetracalcium phosphate and dicalcium phosphate was used as solid phase. The CPC without any gelatin additive was also evaluated as a control group. The results showed that gelatin accelerated hydraulic reactions of the cement paste, in which the reactants were immediately converted into nanostructured apatite precipitates after hardening. Gelatin molecules induced 4%–10% macropores (10–300 μm) into the cement structure, decreased initial setting time by ~190%, and improved mechanical strength of the as-set cement. Variation in the above-mentioned properties was influenced by the gelatin concentration and progressed with increasing the gelatin content. The numbers of the G-292 osteoblastic cells on gelatin-containing CPCs were higher than the control group at entire culture times (1–14 days), meanwhile better alkaline phosphatase (ALP) activity was determined using blooming gelatin additive. The observation of cell morphologies on the cement surfaces revealed an appropriate cell attachment with extended cell membranes on the cements. Overall, adding gelatin to the composition of CPC improved the handling characteristics such as setting time and mechanical properties, enhanced nanoapatite precipitation, and augmented the early cell proliferation rate and ALP activity.

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“…Nevertheless, the clinical applicability of CPCs has remained limited due to two factors: (i) poor degradability due to a lack of interconnected macroporosity to allow for vascularization and bone tissue ingrowth and (ii) poor cohesion and washout resistance, which is especially important when considering their indications for skeletal sites where perfusion is high, such as the spine . For the latter, extraosseous CPC leakage can lead to serious complications, as the release and subsequent washout of CPC particles into the blood stream can stimulate blood clotting and the formation of a pulmonary embolism that can lead to the death of the patient . Therefore, improvement of CPCs cohesive properties is of upmost importance while maintaining an appropriate degradation rate to promote bone tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

“…14,[23][24][25][26] For the latter, extraosseous CPC leakage can lead to serious complications, as the release and subsequent washout of CPC particles into the blood stream can stimulate blood clotting and the formation of a pulmonary embolism that can lead to the death of the patient. 25,27 Therefore, improvement of CPCs cohesive properties is of upmost importance while maintaining an appropriate degradation rate to promote bone tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

Sterilization effects on the handling and degradation properties of calcium phosphate cements containing poly (_D,L‐lactic‐co‐glycolic acid) porogens and carboxymethyl cellulose

Kucko

Martínez

et al. 2019

J Biomed Mater Res

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Injectable, self‐setting calcium phosphate cements (CPCs) are synthetic bone substitutes considered favorable for the repair and regeneration of bone due to their osteocompatibility and unique handling properties. However, their clinical applicability can be compromised due to insufficient cohesion upon injection into the body coupled with poor degradation rates that restricts new bone formation. Consequently, carboxymethyl cellulose (CMC) was incorporated into CPC formulations to improve their cohesion and injectability while poly (D,L‐lactic‐co‐glycolic acid) (PLGA) porogens were added to introduce macroporosity and improve their biodegradation rate. Like most biomaterials, CPCs are gamma irradiated before clinical use to ensure sufficient sterilization. However, it is well known that gamma irradiation also reduces the molecular weight of CMC and PLGA via chain scission, which affects their material properties. Therefore, the aim of this study is to measure the effect that gamma irradiation has on the molecular weight of CMC at varying doses of 15, 40, or 80 kGy and investigate how this affects the handling (i.e., injectability, cohesion, washout, and setting times) and in vitro degradation behavior of CPC formulations. Results reveal that the molecular weight of CMC decreases with increasing gamma irradiation dose, thereby reducing the viscosifying capabilities of CMC, which causes CPCs to deteriorate more readily. Further, the addition of CMC seems to inhibit the degree of phase transformation during cement setting while the subsequent reduction in molecular weight of PLGA after gamma irradiation improves the in vitro degradation rate of CPCs due to the faster degradation rate of low molecular weight PLGA. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2216–2228, 2019.

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A novel injectable, cohesive and toughened Si-HPMC (silanized-hydroxypropyl methylcellulose) composite calcium phosphate cement for bone substitution

Cited by 75 publications

References 60 publications

Effects of adding resorbable chitosan microspheres to calcium phosphate cements for bone regeneration

Effects of adding resorbable chitosan microspheres to calcium phosphate cements for bone regeneration

Blooming gelatin: an individual additive for enhancing nanoapatite precipitation, physical properties, and osteoblastic responses of nanostructured macroporous calcium phosphate bone cements

Sterilization effects on the handling and degradation properties of calcium phosphate cements containing poly (_D,L‐lactic‐co‐glycolic acid) porogens and carboxymethyl cellulose

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A novel injectable, cohesive and toughened Si-HPMC (silanized-hydroxypropyl methylcellulose) composite calcium phosphate cement for bone substitution

Cited by 75 publications

References 60 publications

Effects of adding resorbable chitosan microspheres to calcium phosphate cements for bone regeneration

Effects of adding resorbable chitosan microspheres to calcium phosphate cements for bone regeneration

Blooming gelatin: an individual additive for enhancing nanoapatite precipitation, physical properties, and osteoblastic responses of nanostructured macroporous calcium phosphate bone cements

Sterilization effects on the handling and degradation properties of calcium phosphate cements containing poly (D,L‐lactic‐co‐glycolic acid) porogens and carboxymethyl cellulose

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Sterilization effects on the handling and degradation properties of calcium phosphate cements containing poly (_D,L‐lactic‐co‐glycolic acid) porogens and carboxymethyl cellulose