A Novel In Vivo Rabbit Model of Abdominal Aortic Aneurysm Induced by Periarterial Incubation of Papain

Transauricular intra-arterial and intravenous digital subtraction angiography for abdominal aortic aneurysm imaging in a rabbit model

“…IVDSA was performed successfully in rabbit AAA model in this experiment and previous studies [20], [21]. Miskolczi et al.…”

“…An external sizing device, 1 cm in length, was placed under the abdomen during DSA. The diameters of the aneurysm neck and AAA were measured in reference to this sizing device as previously reported [1], [2], [20], [21], [23], [24]. Aneurysm was defined as an aortic diameter that was dilated at least 50% the diameter of aneurysm neck above.…”

“…Sometimes, this procedure is time-consuming and technically difficult, with the possible complications of hematoma formation, wound infection and limb ischemia [18], [19]. There was almost no usage of non-invasive or minimally invasive imaging alternatives for experimental AAA follow-up, such as IVDSA or DSA via ear central artery in rabbit AAA, except for previous reports [20], [21], [22]. The objective of this study was to evaluate transauricular DSA imaging via ear vein and ear central artery as an alternative to conventional intra-arterial DSA for depiction of anatomy and size of rabbit AAA.…”

Effect of Low-Pressurized Perfusion with Different Concentration of Elastase on the Aneurysm Formation Rate in the Abdominal Aortic Aneurysm Model in Rabbits

“…Origuchi et al [34] reported that aneurysms induced by adventitial elastolysis did not progress, gradually shrank over 42 days, and healed spontaneously by 90 days. Bi et al [35] reported that aneurysms showed progression after day 5; however, long-term follow-up to study the further changes of the model was unwarranted, considering that there was no evidence of aneurysm stability beyond 21 days in the present experiments. In our preliminary experiment, we observed that rabbit AAA developed immediately after operation in the elastase-induced model.…”

A reproducible swine model of proximal descending thoracic aortic aneurysm created with intra-adventitial application of elastase

“…The diameter of the injected part of the aorta (day 0 and day 21) was determined at its maximum point of measurement as previously reported. 23 The distance between the left subclavian artery and the TAA was also measured. All data were collected at least six times, and the average values were used as the final results.…”