A novel hybrid nanoparticle based on Fe3O4/TMAOH/poly(L-co-D,L lactic acid-co-trimethylene carbonate) prepared through the solvent displacement method

Machado, Vagner de Oliveira; Andrade, Ângela Leão; Cavalcante, Luís Carlos Duarte; Fabris, José Domingos; Domingues, Rosana Zacarias; Ardisson, José D.; Fernandez-Outon, L.E.; Pizarro, Carmen; Elias, Carlos Nelson

doi:10.1007/s10751-019-1558-y

Cited by 2 publications

(2 citation statements)

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“…The MNPs were prepared by co-precipitation [ 13 , 14 ]. Briefly, 0.5 mol L −1 solutions of sodium sulfite (10 mmol) and ferric chloride hexahydrate (30 mmol) were mixed in a beaker under mechanical stirring of approximately 800 rpm until the color of the resulting solution changed from dark yellow to light yellow.…”

Section: Methodsmentioning

confidence: 99%

“…Such a composite revealed to be promising as a drug delivery system [ 1 ]. On the other hand, hybrid nanoparticles consisting of MNP cores and PLDLA-co-TMC and PEO–PPO–PEO triblock copolymer shells in different ratios were recently investigated [ 13 , 14 ]. Their extensive physical–chemical characterization enabled electing the most suitable MNP/polymer ratio.…”

Section: Introductionmentioning

confidence: 99%

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Heating Capacity and Biocompatibility of Hybrid Nanoparticles for Magnetic Hyperthermia Treatment

Gomes,

Valverde,

Machado

et al. 2023

IJMS

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Cancer is one of the deadliest diseases worldwide and has been responsible for millions of deaths. However, developing a satisfactory smart multifunctional material combining different strategies to kill cancer cells poses a challenge. This work aims at filling this gap by developing a composite material for cancer treatment through hyperthermia and drug release. With this purpose, magnetic nanoparticles were coated with a polymer matrix consisting of poly (L-co-D,L lactic acid-co-trimethylene carbonate) and a poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) triblock copolymer. High-resolution transmission electron microscopy and selected area electron diffraction confirmed magnetite to be the only iron oxide in the sample. Cytotoxicity and heat release assays on the hybrid nanoparticles were performed here for the first time. The heat induction results indicate that these new magnetic hybrid nanoparticles are capable of increasing the temperature by more than 5 °C, the minimal temperature rise required for being effectively used in hyperthermia treatments. The biocompatibility assays conducted under different concentrations, in the presence and in the absence of an external alternating current magnetic field, did not reveal any cytotoxicity. Therefore, the overall results indicate that the investigated hybrid nanoparticles have a great potential to be used as carrier systems for cancer treatment by hyperthermia.

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Section: Methodsmentioning

confidence: 99%