A novel heterogeneous catalyst based on reduced graphene oxide supported copper coordinated amino acid – A platform for morphine sensing

Kumary, V. Anitha; Abraham, Pinky; Renjini, S; Swamy, B.E. Kumara; Nancy, T.E. Mary; Sreevalsan, Aparna

doi:10.1016/j.jelechem.2019.113367

Cited by 16 publications

(3 citation statements)

References 31 publications

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“…The sensor displayed good anti interference ability, stability and was successfully applied to real sample analysis. 114 An attractive one pot synthesis by electrochemical deposition of Cetyltrimethyl ammonium bromide (CTAB) and graphene oxide (GO) on GCE also functioned as an effective sensitive sensor for MO. The presence of hydroxyl, carboxyl and epoxide group on graphene oxide increases its catalytic properties.…”

Section: Graphene Based Electrodementioning

confidence: 99%

Review—Review on the Progress in Electrochemical Detection of Morphine Based on Different Modified Electrodes

Abraham¹,

Renjini

Vijayan

et al. 2020

J. Electrochem. Soc.

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Morphine is a powerful opioid pain medication and commonly used narcotic pain killer and is toxic during overdose or when abused. Compared to conventional analytical techniques, the electroanalytical method has significant advantages viz. low cost, simplicity, ease of operation and facile miniaturization. In the present paper different approaches based on various modifications adopted for effective electrochemical sensing of morphine are reviewed in a comprehensive way. Among different modified electrodes available for the detection of morphine, carbon based materials—CNTs and graphene—display effective quantification and are attractive in terms of cost compared to noble metals. In addition, the performance of reported sensors in terms of their including detection range (LDR), limit of detection (LOD) and technique used are presented. The present review compares various electroanalytical techniques adopted for the determination of morphine.

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Section: Graphene Based Electrodementioning

confidence: 99%

Review—Review on the Progress in Electrochemical Detection of Morphine Based on Different Modified Electrodes

Abraham¹,

Renjini

Vijayan

et al. 2020

J. Electrochem. Soc.

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“…Copper chloride and alanine were left to react with each other in a buffer solution (pH = 7) to form a complex; then, through electropolymer-ization, the mixture formed a layer on the glassy carbon electrode, before graphene was added to the developed film with the same process. The obtained rGO-Cu-poly(Ala) sensor was able to detect morphine and diclofenac (LoD 47 nM) simultaneously in human blood samples, without any need to pretreat the authentic sample [44].…”

Section: Traditional and Semisynthetic Opioidsmentioning

confidence: 99%

Graphene-Based Electrochemical Sensors for Psychoactive Drugs

Boroujerdi

Paul

2022

Nanomaterials

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Sensors developed from nanomaterials are increasingly used in a variety of fields, from simple wearable or medical sensors to be used at home to monitor health, to more complicated sensors being used by border customs or aviation industries. In recent times, nanoparticle-based sensors have begun to revolutionize drug-detection techniques, mainly due to their affordability, ease of use and portability, compared to conventional chromatography techniques. Thin graphene layers provide a significantly high surface to weight ratio compared to other nanomaterials, a characteristic that has led to the design of more sensitive and reliable sensors. The exceptional properties of graphene coupled with its potential to be tuned to target specific molecules have made graphene-based sensors one of the most popular and well-researched sensing materials of the past two decades with applications in environmental monitoring, medical diagnostics, and industries. Here, we present a review of developments in the applications of graphene-based sensors in sensing drugs such as cocaine, morphine, methamphetamine, ketamine, tramadol and so forth in the past decade. We compare graphene sensors with other sensors developed from ultrathin two-dimensional materials, such as transition-metal dichalcogenides, hexagonal boron nitrate, and MXenes, to measure drugs directly and indirectly, in various samples.

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“…Accordingly, there have been various analytical ways to detect diclofenac and morphine in diverse matrices, some of which are high-performance liquid chromatography [12,13], chemiluminescence [14,15], capillary electrophoresis [16,17], spectrophotometry [18,19], gas chromatography-mass spectroscopy [20,21], thin-layer chromatography [22], and some electrochemical methods [23][24][25][26]. High selectivity, high sensitivity, and minimalinterference impacts are prominent features of a potent analytical method.…”

Section: Introductionmentioning

confidence: 99%

Screen-Printed Graphite Electrode Modified with Graphene-Co3O4 Nanocomposite: Voltammetric Assay of Morphine in the Presence of Diclofenac in Pharmaceutical and Biological Samples

et al. 2022

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This work focuses on the development of a novel electrochemical sensor for the determination of morphine in the presence of diclofenac. The facile synthesis of graphene-Co3O4 nanocomposite was performed. The prepared material (graphene-Co3O4 nanocomposite) was analyzed by diverse microscopic and spectroscopic approaches for its crystallinity, composition, and morphology. Concerning the electrochemical determinations, after drop-casting the as-fabricated graphene-Co3O4 nanocomposite on the surface of a screen-printed graphite electrode (SPGE), their electrochemical performance was scrutinized towards the morphine detection. It was also found that an SPGE modified by a graphene-Co3O4 nanocomposite exhibited better electrocatalytic activity for morphine oxidation than unmodified electrode. Under optimal conditions, the differential pulse voltammetry (DPV) was employed to explore the present sensor (graphene-Co3O4/SPGE), the findings of which revealed a linear dynamic range as broad as 0.02–575.0 µM and a limit of detection (LOD) as narrow as 0.007 μM. The sensitivity was estimated to be 0.4 µM/(µA cm2). Furthermore, the graphene-Co3O4/SPGE sensor demonstrated good analytical efficiency for sensing morphine in the presence of diclofenac in well-spaced anodic peaks. According to the DPV results, this sensor displayed two distinct peaks for the oxidation of morphine and diclofenac with 350 mV potential difference. In addition, the graphene-Co3O4/SPGE was explored for voltammetric determination of diclofenac and morphine in pharmaceutical and biological specimens of morphine ampoule, diclofenac tablet, and urine, where recovery rates close to 100% were recorded for all of the samples.

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A novel heterogeneous catalyst based on reduced graphene oxide supported copper coordinated amino acid – A platform for morphine sensing

Cited by 16 publications

References 31 publications

Review—Review on the Progress in Electrochemical Detection of Morphine Based on Different Modified Electrodes

Review—Review on the Progress in Electrochemical Detection of Morphine Based on Different Modified Electrodes

Graphene-Based Electrochemical Sensors for Psychoactive Drugs

Screen-Printed Graphite Electrode Modified with Graphene-Co3O4 Nanocomposite: Voltammetric Assay of Morphine in the Presence of Diclofenac in Pharmaceutical and Biological Samples

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