A Novel Heterodimer of Coumaric Acid Glucosides from the Chinese Fern Polypodium hastatum

Li, Yan; Li, Kaijin; Duan, Jingyu; Zhang, Chunping; Yao, Huankai

doi:10.1007/s10600-018-2550-5

Cited by 6 publications

(1 citation statement)

References 3 publications

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“…The peaks at Rt 7.4 and 9.9 min were tentatively identified as isomeric glycosidic forms of coumaric acid, for instance the glucose esters of o -coumaric acid (melilotoside) and p -coumaric acid. 15 , 16 The former was reported as a putative metabolite in parsley. 17 …”

Section: Resultsmentioning

confidence: 99%

Oral treatment with a chemically characterized parsley (Petroselinum crispum var. neapolitanum Danert) aqueous extract reduces thrombi formation in rats

Frattani

Assafim

Casanova

et al. 2021

Journal of Traditional and Complementary Medicine

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Petroselinum crispum var . neapolitanum Danert (Apiaceae) (PC), popularly known as parsley, is an herb native to the Mediterranean region widely cultivated around the world for culinary and ethnomedicinal purposes. The herb is traditionally used in various parts of the world to treat arterial hypertension, hemorrhoid, nose bleeding, hyperlipidemia, and pain, among other indications. The aim of this study was to evaluate the antithrombotic activity of an aqueous extract PC in rats. Aerial parts of a flat-leaf variety of parsley were extracted by decoction. In vivo thrombosis in rat models as well as ex vivo assays were used in the evaluation of PC antithrombotic effects. Intravenous administration of PC (25 mg/kg.b.w), 5 min before thrombosis induction, reduced the venous thrombus formation by 98.2%, while oral administration (125 mg/kg.b.w) impaired it by 76.2%. In the arterial thrombosis model, the oral administration of PC at 15 or 25 mg/kg.b.w, 60 min before thrombosis induction, increased the carotid artery occlusion time by 150% (37.0 ± 6.44 min) and 240% (more than 60 min), respectively. A HPLC-DAD-MS/MS profile of PC extract used in this study was provided. Apiin showed to be the most abundant phenolic compound in the extract. It also revealed the presence of many coumaric acid derivatives. Our results indicate that PC is a potential candidate for the development of a phytotherapeutic drug in the treatment of thromboembolic diseases and provide a detailed chemical profile useful for controlling PC extract production in view of phytotherapy.

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Section: Resultsmentioning

confidence: 99%