A novel H<sub>2</sub>O<sub>2</sub>responsive supramolecular hydrogel for controllable drug release

Ren, Chunhua; Chu, Liping; Huang, Fan; Yang, Lijun; Fan, Huirong; Liu, Jianfeng; Yang, Cuihong

doi:10.1039/c6ra26536g

Cited by 31 publications

(21 citation statements)

References 72 publications

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“…The behavior observed in Fig. 9(a) also suggests that the gradual increase in light absorption can be attributed to the localized surface-plasmon resonance (LSPR) of Ag nanoparticles, as previously reported by Ding et al and Ren et al [26,52]. In addition, the band-gap energies of the assynthesized samples were estimated by the well-known Tauc equation [53].…”

Section: àsupporting

confidence: 76%

Silver-controlled evolution of morphological, structural, and optical properties of three-dimensional hierarchical WO 3 structures synthesized from hydrothermal method

Lopes

Pontes

Garcia

et al. 2018

Journal of Alloys and Compounds

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Hierarchical structures of self-assembled three-dimensional (3D) WO 3 eAg were synthesized via hydrothermal growth using precursor solutions of peroxopolytungstic acid with different amounts of Ag. The as-grown samples were analyzed by X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), thermogravimetric analysis (TGA), Raman spectroscopy, Fourier transform infrared (FTIR) spectroscopy, ultravioletevisible spectroscopy, and X-ray photoelectron spectroscopy. The XRD and Raman studies showed that as the amount of Ag was varied from 0 to 10 wt% in the hydrothermal growth solution, the crystal phase gradually changed from orthorhombic WO 3 $0.33H 2 O to hexagonal WO 3. The FTIR and TGA studies revealed different hydration levels, supporting the XRD and Raman results. By controlling the amount of Ag in the precursor solution, platelet-like building blocks and hexagonal building blocks were obtained, highlighting the role of Ag in the hydrothermal growth of 3D WO 3 $0.33H 2 O and WO 3 microcrystals. In addition, high-magnification FESEM images showed that the Ag nanoparticles were anchored on the surface of the 3D hierarchical WO 3 eAg structures, and the UVevis measurements demonstrated that the 3D hierarchical structures gradually absorbed more light when the Ag content was increased. Moreover, the band-gap energy decreased when the Ag content was increased from 0 wt% (E g ¼ 2.65 eV) to 10 wt% (E g ¼ 2.26 eV). These experimental results demonstrate that the amount of Ag played a crucial role in determining the building blocks' morphology, and the hydration level, optical properties, and crystal phase of the WO 3 $nH 2 O microcrystals.

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Section: àsupporting

confidence: 76%

Silver-controlled evolution of morphological, structural, and optical properties of three-dimensional hierarchical WO 3 structures synthesized from hydrothermal method

Lopes

Pontes

Garcia

et al. 2018

Journal of Alloys and Compounds

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“…Besides GSH, another redox active agent ubiquitously found in biological systems is H 2 O 2 which within tolerable limits acts as an intracellular signalling agent but at heightened levels can lead to high oxidative stress and cellular damage ( Ren et al, 2017 ). Escalated production of H 2 O 2 in certain pathological conditions such as cancer and cardiovascular diseases has provided impetus for developing H 2 O 2 sensitive smart drug carriers.…”

Section: Stimuli-responsive Hydrogelsmentioning

confidence: 99%

Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications

Das

2021

Front. Chem.

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Peptide-based hydrogels have captivated remarkable attention in recent times and serve as an excellent platform for biomedical applications owing to the impressive amalgamation of unique properties such as biocompatibility, biodegradability, easily tunable hydrophilicity/hydrophobicity, modular incorporation of stimuli sensitivity and other functionalities, adjustable mechanical stiffness/rigidity and close mimicry to biological molecules. Putting all these on the same plate offers smart soft materials that can be used for tissue engineering, drug delivery, 3D bioprinting, wound healing to name a few. A plethora of work has been accomplished and a significant progress has been realized using these peptide-based platforms. However, designing hydrogelators with the desired functionalities and their self-assembled nanostructures is still highly serendipitous in nature and thus a roadmap providing guidelines toward designing and preparing these soft-materials and applying them for a desired goal is a pressing need of the hour. This review aims to provide a concise outline for that purpose and the design principles of peptide-based hydrogels along with their potential for biomedical applications are discussed with the help of selected recent reports.

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“…Numerous peptide-based supramolecular hydrogels have been successfully designed by using a peptide with higher length. Among others, the supramolecular naphthalene-GFFYEE-catechol hydrogel contains bortezomib [ 112 ], an H 2 O 2 -responsive hexapeptide-based hydrogelator bearing the thiazolidinone group with gemcitabine [ 113 ], and supramolecular peptide amphiphile nanofiber gels (Lauryl-VVAGEEE-OH and Lauryl-VVAGKKK-Am) with doxorubicin, which were encapsulated within the gels [ 114 ].…”

Section: Supramolecular Hydrogels As Carriers For Biologically Active Substancesmentioning

confidence: 99%

From Supramolecular Hydrogels to Multifunctional Carriers for Biologically Active Substances

Skopińska-Wiśniewska

Flor

Kozłowska

2021

IJMS

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Supramolecular hydrogels are 3D, elastic, water-swelled materials that are held together by reversible, non-covalent interactions, such as hydrogen bonds, hydrophobic, ionic, host–guest interactions, and metal–ligand coordination. These interactions determine the hydrogels’ unique properties: mechanical strength; stretchability; injectability; ability to self-heal; shear-thinning; and sensitivity to stimuli, e.g., pH, temperature, the presence of ions, and other chemical substances. For this reason, supramolecular hydrogels have attracted considerable attention as carriers for active substance delivery systems. In this paper, we focused on the various types of non-covalent interactions. The hydrogen bonds, hydrophobic, ionic, coordination, and host–guest interactions between hydrogel components have been described. We also provided an overview of the recent studies on supramolecular hydrogel applications, such as cancer therapy, anti-inflammatory gels, antimicrobial activity, controlled gene drug delivery, and tissue engineering.

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A novel H₂O₂responsive supramolecular hydrogel for controllable drug release

Abstract: We reported a peptide-based supramolecular hydrogel possessing a gel–sol phase transition triggered by H2O2.

Cited by 31 publications

References 72 publications

Silver-controlled evolution of morphological, structural, and optical properties of three-dimensional hierarchical WO 3 structures synthesized from hydrothermal method

Silver-controlled evolution of morphological, structural, and optical properties of three-dimensional hierarchical WO 3 structures synthesized from hydrothermal method

Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications

From Supramolecular Hydrogels to Multifunctional Carriers for Biologically Active Substances

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A novel H2O2responsive supramolecular hydrogel for controllable drug release

Abstract: We reported a peptide-based supramolecular hydrogel possessing a gel–sol phase transition triggered by H2O2.

Cited by 31 publications

References 72 publications

Silver-controlled evolution of morphological, structural, and optical properties of three-dimensional hierarchical WO 3 structures synthesized from hydrothermal method

Silver-controlled evolution of morphological, structural, and optical properties of three-dimensional hierarchical WO 3 structures synthesized from hydrothermal method

Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications

From Supramolecular Hydrogels to Multifunctional Carriers for Biologically Active Substances

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Product

Resources

About

A novel H₂O₂responsive supramolecular hydrogel for controllable drug release