A novel H-2K splice form: predictions for other alternative H-2 splicing events

Vogel, Julie M.; Morse, Roxanne; Goodenow, Robert S.

doi:10.1007/bf02341611

Cited by 7 publications

(2 citation statements)

References 45 publications

(58 reference statements)

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“…MicroRNAs that are linked to the therapy resistance and sensitivity are the ones engaged in cancer cell survival. In glioblastoma, these microRNAs are currently under investigation: miR-183/96/182 , miR-143 , miR-449a , miR-107 , miR-122 , miR-152 and miR-217 miR-200a , miR-873 , let-7b , miR-136 , miR-139 , miR-1 , miR-451 , miR-143 , miR-603 , miR-100 , miR-96 , miR-93-5p , miR-146b , miR-183 , miR-378 , miR-125b/20b , miR-338-5b , miR-203 (Table 2) [187,188,189,190,191,192,193,194,195,196,197,198,199,200,201,202,203,204].…”

Section: More About Microrna In Neuropathologymentioning

confidence: 99%

MicroRNA in Brain pathology: Neurodegeneration the Other Side of the Brain Cancer

Godlewski

Lenart

Salińska

2019

ncRNA

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The mammalian brain is made up of billions of neurons and supporting cells (glial cells), intricately connected. Molecular perturbations often lead to neurodegeneration by progressive loss of structure and malfunction of neurons, including their death. On the other side, a combination of genetic and cellular factors in glial cells, and less frequently in neurons, drive oncogenic transformation. In both situations, microenvironmental niches influence the progression of diseases and therapeutic responses. Dynamic changes that occur in cellular transcriptomes during the progression of developmental lineages and pathogenesis are controlled through a variety of regulatory networks. These include epigenetic modifications, signaling pathways, and transcriptional and post-transcriptional mechanisms. One prominent component of the latter is small non-coding RNAs, including microRNAs, that control the vast majority of these networks including genes regulating neural stemness, differentiation, apoptosis, projection fates, migration and many others. These cellular processes are also profoundly dependent on the microenvironment, stemness niche, hypoxic microenvironment, and interactions with associated cells including endothelial and immune cells. Significantly, the brain of all other mammalian organs expresses the highest number of microRNAs, with an additional gain in expression in the early stage of neurodegeneration and loss in expression in oncogenesis. However, a mechanistic explanation of the concept of an apparent inverse correlation between the odds of cancer and neurodegenerative diseases is only weakly developed. In this review, we thus will discuss widespread de-regulation of microRNAome observed in these two major groups of brain pathologies. The deciphering of these intricacies is of importance, as therapeutic restoration of pre-pathological microRNA landscape in neurodegeneration must not lead to oncogenesis and vice versa. We thus focus on microRNAs engaged in cellular processes that are inversely regulated in these diseases. We also aim to define the difference in microRNA networks between pro-survival and pro-apoptotic signaling in the brain.

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Section: More About Microrna In Neuropathologymentioning

confidence: 99%

MicroRNA in Brain pathology: Neurodegeneration the Other Side of the Brain Cancer

Godlewski

Lenart

Salińska

2019

ncRNA

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“…A minor component is missing both exon 5 and 7 sequences. Alternative splicing of class I RNA occurs in a number of instances in humans and mice (34)(35)(36). The functional significance of these observations, if any, is still unknown.…”

Section: Discussionmentioning

confidence: 99%

Structural and functional analysis of three D/L-like class I molecules from H-2v: indications of an ancestral family of D/L genes.

Cai

Pease

1992

The Journal of Experimental Medicine

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Class I major histocompatibility complex cDNA clones from sheep thymus: alternative splicing could make a long cytoplasmic tail

Grossberger¹,

Hein²,

Marcuz³

1990

Immunogenetics

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To investigate the class I major histocompatibility complex (MHC) genes expressed in the young sheep thymus, a cDNA library was screened with a human HLA-B7 cDNA probe under conditions of relaxed stringency. Thirteen clones were isolated and found by partial sequences to fall into five classes, requiring the expression of at least three loci. One sequence was found six times, almost half of the total, and may thus represent the major message expressed in the young sheep thymus. One of the clones was found to have failed to excise the intron between cytoplasmic exons 7 and 8, leading to the predicted synthesis of a cytoplasmic domain 23 amino acids longer than the other sheep sequences, and 15 amino acids longer than any cytoplasmic domain previously described. The sequences of all the clones were found to be most similar to bovine, and least similar to mouse class I MHC sequences.

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A novel H-2K splice form: predictions for other alternative H-2 splicing events

Cited by 7 publications

References 45 publications

MicroRNA in Brain pathology: Neurodegeneration the Other Side of the Brain Cancer

MicroRNA in Brain pathology: Neurodegeneration the Other Side of the Brain Cancer

Structural and functional analysis of three D/L-like class I molecules from H-2v: indications of an ancestral family of D/L genes.

Class I major histocompatibility complex cDNA clones from sheep thymus: alternative splicing could make a long cytoplasmic tail

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