A novel group of ovarian toxicants: The psoralens

Diawara, Moussa M.; Chavez, Kathryn J.; Hoyer, Patricia B.; Williams, David E.; Dorsch, Jeremías; Kulkosky, Paul J.; Franklin, Michael R.

doi:10.1002/(sici)1099-0461(1999)13:3/4<195::aid-jbt10>3.0.co;2-p

Cited by 34 publications

(10 citation statements)

References 37 publications

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“…Our subsequent studies demonstrated that the two compounds administered to females only (mated to undosed males) reduced the numbers of implantation sites, fetuses, and corpora lutea in pregnant females compared with the control group [34]. The two compounds also reduced levels of circulating blood estrogen in nonpregnant females.…”

Section: Toxicitymentioning

confidence: 81%

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Reproductive Toxicity of the Psoralens

Diawara

Kulkosky

2003

Pediatric Pathology & Molecular Medicine

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The psoralens are naturally occurring secondary metabolites in plants, including many fruits and vegetables. Health risks have been associated with handling or ingesting psoralen-containing plants, and with the use of synthetic psoralens in photochemotherapy of skin disorders. Our research has demonstrated that administration of the psoralens bergapten (5-methoxypsoralen) and xanthotoxin (8-methoxypsoralen) in the diet of female rats reduced birthrates, number of implantation sites, pups, corpora lutea, full and empty uterine weight, and circulating estrogen levels in a dose-dependent manner. Psoralens induced mRNAs of the liver enzymes CYP1A1 and UGT1A6, suggesting that enhanced metabolism of estrogens by psoralen treatment may explain the reproductive toxicity and the observed reduction of ovarian follicular function and ovulation. Rats also avoided repeated consumption of a flavored solution associated with psoralen administration. The findings indicate that the psoralens constitute a novel group of ovarian toxicants. Further examination of the safety of their use in photochemotherapy and diet is warranted.

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Section: Toxicitymentioning

confidence: 81%

“…During subsequent studies, we dosed females rats, mated them with undosed males, and sacri¢ced them the day before parturition [34]. Bergapten and xanthotoxin administered to only female rats, either alone or in combination, still signi¢cantly reduced the birthrate.…”

Section: Methodsmentioning

confidence: 99%

Reproductive Toxicity of the Psoralens

Diawara

Kulkosky

2003

Pediatric Pathology & Molecular Medicine

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“…Circulating levels of estradiol were lower in bergaptin and xanthotoxin-treated rats [7]. Bergaptin and xanthotoxin are synthetic chemicals used in skin photochemotherapy and members of the psoralens family of chemicals that are found in many crop plants.…”

Section: Steroidogenesismentioning

confidence: 99%

“…Endocrine disrupters alter ovarian steroidogenesis indirectly by attenuating pituitary gonadotropin levels in serum [5] and directly through changes in steroidogenic enzyme expression and/ or activity [6,30] and steroid hormone turnover [7].…”

Section: Steroidogenesismentioning

confidence: 99%

Endocrine disrupters and ovarian function

Foster

Neal

Younglai

2004

International Congress Series

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“…Studies on the effect of psoralens on reproductive function have reported a dose -dependent effect of 5 -MOP and 8 -MOP in the presence of UVA light on birth rate in female rats. The number of offspring was reduced along with a reduction in uterine weight and serum estradiol levels (Diawara et al , 1999 ). This was determined to be due to reduced ovulations resulting from targeting of granulosa cells.…”

Section: Psoralensmentioning

confidence: 99%