A novel glucuronoxylan hydrolase produced by fermentation is safe as feed additive: toxicology and tolerance in broiler chickens

Safety and efficacy profile of a phytase produced by fermentation and used as a feed additive

“…Toxicological studies were performed to evaluate the safety of this new Phytase HM following the guidance by Pariza and his colleagues (Pariza and Johnson, 2001;Pariza and Cook, 2010) and consistent with the safety assessment of enzymes performed by Nov akov a, Lichtenberg, and Aureli (Nov akov a et al, 2021;Lichtenberg et al, 2011Lichtenberg et al, , 2017Aureli et al, 2018). The studies reported here comply with the requirements of the European Union Regulation N 1831/2003 on additives for use in animal nutrition and the corresponding guidelines (EFSA, 2017a;2017b).…”

“…Many different enzymes are used to optimize nutrient utilization from feed ingredients; e.g. use of amylases, glucanases, xylanases, hemi-cellulases, muramidases and proteases (Adeola and Cowieson, 2011;Aureli et al, 2018;Dersjant-Li et al, 2015;Lichtenberg et al, 2017 Cowieson andRoos, 2016) enhances the bioavailability of nutrients for the animal and/or for its intestinal microbiota (Jozefiak et al, 2010;Bedford and Cowieson, 2012;Kiarie et al, 2013). Enzymes can reduce the cost of feed by optimizing the feed utilization, as this will lead to a reduced consumption of feed.…”

Identification of Plant Soot as Novel Safe Feed Additive: Evaluation of 90-Day Oral Toxicity and Prenatal Developmental Toxicity in Rats

“…In recent years, the prohibition and restriction of using veterinary antibiotics in livestock diets has become an important topic concerning human health. Most of the veterinary antibiotics have been forbidden as growth promoters in many countries due to the development of drug-resistant bacteria and the threat posed by drug residues, thus new antibiotic substitution strategies and alternative feed additives such as microecological preparations and herbal medicine is gradually becoming the mainstream trend (1,2). One of the natural herbal medicines, plant soot, has been certified to adsorb intestinal mycotoxin, inhibit bacterial infection, and promote animal digestion, whose first industrial product has just been approved for use in feed additives by China in January 2020, without other details published concerning its toxicity analysis (3).…”

Efficacy and safety profile of a subtilisin protease produced by fermentation in Bacillus licheniformis to be used as a feed additive

“…Enzymes added to animal feed have in modern days gained popularity, due to the increase in nutrient digestibility that leads to benefit in nutrition, while reducing the environmental impact. The use of various enzymes enhances nutrient utilization from feed ingredients (Adeola and Cowieson, 2011;Aureli et al, 2018;Cowieson and Roos, 2016;Dersjant-Li et al, 2015;Rebello et al, 2019). As summarized by Ohja and colleagues, in addition to the improvement of digestion of nutrients, enzymes can aid in the release of micronutrients (Ojha et al, 2019); and as a result of less undigested food reaching the lower gut and the intestinal microbiota, there is a general improvement of gut health (Bedford and Cowieson, 2012;Ojha et al, 2019).…”