A Novel Glucose-Sensitive Scaffold Accelerates Osteogenesis in Diabetic Conditions

Abstract

Mandibular bone regeneration is still a big challenge in those diabetic patients with poorly controlled blood glucose. In this study, we prepared a novel glucose-sensitive controlled-release fiber scaffold (PVA-HTCC/PEO-rhBMP2-glucose oxidase (PHPB-G)), which contained the recombinant human bone morphogenetic protein 2 (rhBMP2) by coaxial cospinning and grafted with glucose oxidase (GOD). We presented evidence that PHPB-G could undergo a series of structural changes with the blood glucose and promoted bone regeneration in diabetic rat. PHPB-G expanded the voids in nanofibers when blood glucose levels elevated. More importantly, its slow-release rhBMP2 effectively promoted the healing of bone defects. These data suggested that the PHPB-G delivery system may provide a potential treatment strategy for patients with severe diabetic alveolar bone defects.

Current developments and future perspectives of nanotechnology in orthopedic implants: an updated review

“…For example, Deng et al developed porous PEEK scaffolds having a coating that gave the biomaterial a unique acidic pH-responsive property capable of being triggered by bacteria ( Figure 6 ) ( Deng et al, 2020 ). Recombinant human bone morphogenetic protein 2 (rhBMP-2) and glucose oxidase were grafted onto a new glucose-sensitive controlled-release fiber scaffold fabricated by Jiang et al to support bone regeneration ( Jiang et al, 2022 ). A titanium bone prosthesis with an immobilized surface that contains both an MMP-9 responsive peptide and the antimicrobial peptide GL13K was developed by Fischer et al to respond to both MMPs and bacteria ( Fischer et al, 2021 ).…”

Choosing the right animal model for osteomyelitis research: Considerations and challenges

“…Numerous researchers have investigated the relationship between bone defect healing and various factors including osteogenesis, angiogenesis and macrophage polarization in diabetic conditions. Predominantly, rat models have been utilized in these studies, with bone defects created in the calvarium [ 169 , [174] , [175] , [176] ], mandible [ 177 ], and femur [ 178 , 179 ]. Type 1 or type 2 diabetic mellitus was induced by consumption of high-fat food and intraperitoneal injection of streptozotocin (STZ), resulting in glycemia and fluctuation of blood glucose levels [ 169 , 180 ].…”