Smart orthopedic biomaterials and implants

Intravaia, Jonathon T.; Graham, Trevon; Nanda, Himansu Sekhar; Kumbar, Sangamesh G.; Nukavarapu, Syam P.

doi:10.1016/j.cobme.2022.100439

Cited by 12 publications

(6 citation statements)

References 86 publications

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“…The reason for this is that, among other things, the fracture healing process depends on a great number of factors [ 26 , 76 , 77 ]. The composition of the materials used also affects the quality of the return and the condition of the patient [ 78 , 79 , 80 , 81 ]. These issues have not been addressed by the studies conducted, but future plate models with a high MEF can be selected for further development without conducting expensive strength tests.…”

Section: Discussionmentioning

confidence: 99%

Which of 51 Plate Designs Can Most Stably Fixate the Fragments in a Fracture of the Mandibular Condyle Base?

Kozakiewicz

Okulski

Krasowski

et al. 2023

JCM

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In the surgical treatment of the most common fracture of the mandible, which is a fracture of the condylar base, a great choice of different plate shapes is observed. The aim of this study was to determine which shape gives the greatest fixation stiffness. To ensure homogeneity in comparison, tests were performed on polyurethane models divided at the level of the condylar base fracture and each were fixed with 51 plates. The plates were cut from a 1 mm thick grade 23 titanium sheet. The models were then loaded and the force required for 1 mm of fracture displacement was recorded. It was noted that in addition to osteosynthesis from two simple plates, there were also two dedicated single plates with similar rigidity. Among the large number of described designs of plates, there is considerable variation in terms of the stability of the fixation performed with them. The proposed Mechanical Excellence Factor allows a pre-evaluation of the expected rigidity of fixation with a given plate shape without the need for a loading experiment. The authors expect this to be helpful for surgeons in the application of relevant plates, as well for inventors of new plates for the osteosynthesis of basal fractures in mandibular condyle.

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Section: Discussionmentioning

confidence: 99%

Which of 51 Plate Designs Can Most Stably Fixate the Fragments in a Fracture of the Mandibular Condyle Base?

Kozakiewicz

Okulski

Krasowski

et al. 2023

JCM

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“…Research on the interactions between cellular material and parameters such as topography, stiffness, porosity, and functional groups provided the basis for the ability to modify cell behavior. Smart/intelligent biomaterials and implants are produced by incorporating these characteristics into biomaterials and their 3D shapes ( Intravaia et al, 2022 ). Smart or intelligent biomaterials are those that have the potential to stimulate tissue regrowth through physical, chemical, electrical, or magnetic stimuli.…”

Section: Current Developments Of Nanotechnology In Orthopedic Implantsmentioning

confidence: 99%

Current developments and future perspectives of nanotechnology in orthopedic implants: an updated review

Liang,

Zhou,

Bai

et al. 2024

Front. Bioeng. Biotechnol.

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Orthopedic implants are the most commonly used fracture fixation devices for facilitating the growth and development of incipient bone and treating bone diseases and defects. However, most orthopedic implants suffer from various drawbacks and complications, including bacterial adhesion, poor cell proliferation, and limited resistance to corrosion. One of the major drawbacks of currently available orthopedic implants is their inadequate osseointegration at the tissue-implant interface. This leads to loosening as a result of immunological rejection, wear debris formation, low mechanical fixation, and implant-related infections. Nanotechnology holds the promise to offer a wide range of innovative technologies for use in translational orthopedic research. Nanomaterials have great potential for use in orthopedic applications due to their exceptional tribological qualities, high resistance to wear and tear, ability to maintain drug release, capacity for osseointegration, and capability to regenerate tissue. Furthermore, nanostructured materials possess the ability to mimic the features and hierarchical structure of native bones. They facilitate cell proliferation, decrease the rate of infection, and prevent biofilm formation, among other diverse functions. The emergence of nanostructured polymers, metals, ceramics, and carbon materials has enabled novel approaches in orthopaedic research. This review provides a concise overview of nanotechnology-based biomaterials utilized in orthopedics, encompassing metallic and nonmetallic nanomaterials. A further overview is provided regarding the biomedical applications of nanotechnology-based biomaterials, including their application in orthopedics for drug delivery systems and bone tissue engineering to facilitate scaffold preparation, surface modification of implantable materials to improve their osteointegration properties, and treatment of musculoskeletal infections. Hence, this review article offers a contemporary overview of the current applications of nanotechnology in orthopedic implants and bone tissue engineering, as well as its prospective future applications.

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“…[465][466][467][468] These fractures of complex structures can be solved by using the combination of SRPs and AM to fabricate dynamic and patient-specific scaffolds, which permit the regeneration of tissues. [469][470][471] Additionally, the flexibility and minimally invasive implantation of 4D-printed scaffolds make them highly suitable for bone Figure 12. A) Multi-responsive actuator developed by DIW printing.…”

Section: Biomedical Sectormentioning

confidence: 99%

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Tariq,

Arif,

Khalid

et al. 2023

Adv Eng Mater

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Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, soft robots, wearable devices, sensors, self‐expanding structures, and biomedical devices, thanks to their ability to change their shapes and functional properties in response to external stimuli including light, humidity, heat, pH, electric field, solvent, and magnetic field or combinations of two or more of these stimuli. In recent years, additive manufacturing (AM) aka three‐dimensional (3D) printing technology of these SRPs, also known as four‐dimensional (4D) printing, has gained phenomenal attention in different engineering fields, thanks to its unique ability to develop complex, personalized, and innovative structures, which undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, and other complex morphological transformations. Herein, an effort has been made to provide insightful information about the AM techniques, type of SRPs, and their applications including, but not limited to tissue engineering, soft robots, bionics, actuators, sensors, construction, and smart textiles. This article also incorporates the current challenges and prospects, hoping to provide an insightful basis for the utilization of this technology in different engineering fields. It is expected that the amalgamation of 3D printing with SRPs would provide unparalleled advantages in different engineering arenas.This article is protected by copyright. All rights reserved.

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Smart orthopedic biomaterials and implants

Cited by 12 publications

References 86 publications

Which of 51 Plate Designs Can Most Stably Fixate the Fragments in a Fracture of the Mandibular Condyle Base?

Which of 51 Plate Designs Can Most Stably Fixate the Fragments in a Fracture of the Mandibular Condyle Base?

Current developments and future perspectives of nanotechnology in orthopedic implants: an updated review

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

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