A Novel Eplerenone Ecofriendly Fluorescent Nanosensor Based on Nitrogen and Sulfur-Carbon Quantum Dots

Belal, Fathalla; Mabrouk, Mokhtar M.; Hammad, Sherin F.; Barseem, Aya; Ahmed, Hytham M.

doi:10.1007/s10895-020-02638-4

Cited by 16 publications

(16 citation statements)

References 30 publications

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“…The quantum yield (QY) of the NBD‐EE fluorescent derivative was calculated according to the equation [28]:

ɸ_{x} goodbreak= ɸ_{st} goodbreak\times \frac{{normalF}_{normalx}}{{normalF}_{st}} goodbreak\times {(\frac{{normalɳ}_{normalx}}{{normalɳ}_{st}})}^{2} goodbreak\times \frac{{normalA}_{st}}{{normalA}_{normalx}}

in which the st subscript is the reference sample and the x subscript is the unknown sample; Φ is the QY; F is the integrated measured emission intensity; A is absorbance and η is the refractive index of solvent.…”

Section: Methodsmentioning

confidence: 99%

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4‐Azido‐7‐nitrobenzoxadiazole as innovative clickable fluorescence probe for trace and selective quantification of ethinylestradiol in human plasma

Aref¹,

Salama

Aboukhatwa

et al. 2023

Luminescence

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Quantification of Ethinylestradiol (EE) in biological matrices is challenging since it is a very potent drug with a very low Cmax (75 pg.mL‐1). Despite the high sensitivity of fluorometric methods, detection of EE by them is confined because its structure exhibited very limited fluorescence. Therefore, it must be derivatized first using a fluorogenic agent to produce more potent fluorescent derivative to achieve the desired ultra‐sensitive bioanalysis. Herein, For the first time, we proposed a promising click fluorescent probe, 4‐azido‐7‐nitrobenzoxadiazole (NBD‐AZ) to react with the alkyne group of EE, by the help of copper sulphate and L‐ascorbic acid to give a highly fluorescent and stable 1,2,3‐ triazole derivative. Density functional theory calculation revealed how the triazole formation affects the quantum yield and fluorescence of click reaction product when comparing to NBD‐AZ. The resulting triazole exhibited strong signal at wavelength of 540 nm after excitation at 470 nm. Reaction parameters impacting the intensity of fluorescence were cautiously studied and optimized. The suggested approach has shown outstanding performance, high linearity (25‐300 pg.mL‐1) and low detection limit of 7.5 pg.mL‐1. The enhanced sensitivity and selectivity were exploited for analysing EE in plasma using liquid‐liquid extraction for samples cleaning up without interference from any biological components and with mean % recovery of 100.13±0.39. Accuracy, sensitivity, selectivity, simplicity, and cost‐effectiveness make this approach a convincing, promising, and appealing alternative over the reported analytical methods for EE bioanalysis in different matrices.

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“…The quantum yield (QY) of the NBD‐EE fluorescent derivative was calculated according to the equation [28]:

ɸ_{x} goodbreak= ɸ_{st} goodbreak\times \frac{{normalF}_{normalx}}{{normalF}_{st}} goodbreak\times {(\frac{{normalɳ}_{normalx}}{{normalɳ}_{st}})}^{2} goodbreak\times \frac{{normalA}_{st}}{{normalA}_{normalx}}

Section: Methodsmentioning

confidence: 99%

“…The quantum yield (QY) of the NBD-EE fluorescent derivative was calculated according to the equation [28]:…”

Section: Quantum Yield Calculationmentioning

confidence: 99%

4‐Azido‐7‐nitrobenzoxadiazole as innovative clickable fluorescence probe for trace and selective quantification of ethinylestradiol in human plasma

Aref¹,

Salama

Aboukhatwa

et al. 2023

Luminescence

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“…Synthesis of nano-sensor was performed applying a simple hydrothermal method recently reported in the literature. 47,48 The uorescent N, S-CQDs probe of concentration of 1.0 g L À1 , was prepared from CA and TSC as starting materials in a onestep hydrothermal method. The probes were made by sonicating a mixture of TSC (0.68 g, 7.50 mM) and CA (0.52 g, 2.50 mM) in 20.0 mL of double distilled water.…”

Section: Synthesis Of Uorescent Probementioning

confidence: 99%

Thiosemicarbazide functionalized carbon quantum dots as a fluorescent probe for the determination of some oxicams: application to dosage forms and biological fluids

et al. 2022

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“…For example, N,S‐doped CQDs express a high degree of photostability and quantum yield. [ 43–47 ] Their fluorescence intensity can be reduced using interesting analytes and therefore provide a basis for expanded applications of analysis.…”

Section: Introductionmentioning

confidence: 99%

One‐pot synthesis of fluorescent nitrogen and sulfur–carbon quantum dots as a sensitive nanosensor for trimetazidine determination

et al. 2021

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Water‐soluble and highly stable N,S‐doped CQDs (N,S‐CQDs) were synthesized using a low‐cost strategy with citric acid and thiosemicarbazide in one step for use as a fluorescent nanosensor. The achieved N,S‐CQDs produced strong emission at 446 nm upon excitation at 370 nm and a high quantum yield of 58.5%. The quenching effect on the prepared N,S‐CQDs was utilized for determination of trimetazidine (TMZ) spectrofluorimetrically over a wide linear range 0.04–0.5 μM (0.0106–0.133 μg ml−1) and a low limit of detection of 0.01 μM (0.002 μg ml−1). Furthermore, CDs were used as a simple and rapid fluorescent probe to determine TMZ in its pharmaceutical formulations as well as in human plasma. The method was tested in compliance with International Council for Harmonisation guidelines. The results obtained were compared statistically with those given for a reported method showing no significant variation regards accuracy and precision.

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A Novel Eplerenone Ecofriendly Fluorescent Nanosensor Based on Nitrogen and Sulfur-Carbon Quantum Dots

Cited by 16 publications

References 30 publications

4‐Azido‐7‐nitrobenzoxadiazole as innovative clickable fluorescence probe for trace and selective quantification of ethinylestradiol in human plasma

4‐Azido‐7‐nitrobenzoxadiazole as innovative clickable fluorescence probe for trace and selective quantification of ethinylestradiol in human plasma

Thiosemicarbazide functionalized carbon quantum dots as a fluorescent probe for the determination of some oxicams: application to dosage forms and biological fluids

One‐pot synthesis of fluorescent nitrogen and sulfur–carbon quantum dots as a sensitive nanosensor for trimetazidine determination

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