A novel epigenetic marker, Ten-eleven translocation family member 2 (TET2), is identified in the intractable epileptic brain and regulates ATP binding cassette subfamily B member 1 (ABCB1) in the blood–brain barrier

Kong, Fan-Cheng; Lang, Liwei; Hu, Jie; Zhang, Xialing; Zhong, Mingkang; Ma, Chun-Lai

doi:10.1080/21655979.2022.2045838

Cited by 2 publications

(2 citation statements)

References 55 publications

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“…Apart from DNA mutations, changes in gene (and protein) expression can occur at multiple levels, The role of epigenetics at the blood-brain barriers is relatively understudied. There is recent evidence that the demethylation factor Tet methylcytosine dioxygenase 2 (TET2) regulates the tight junction protein ZO-1 [ 109 ] and p-glycoprotein (ABCB1) [ 110 ] and that differences in methylation of the claudin-5 gene are associated with the trajectory of cognitive decline in patients [ 111 ].…”

Section: Genetics and The Blood-brain Barriersmentioning

confidence: 99%

A year in review: brain barriers and brain fluids research in 2022

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Hamilton

et al. 2023

Fluids Barriers CNS

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This aim of this editorial is to highlight progress made in brain barrier and brain fluid research in 2022. It covers studies on the blood-brain, blood-retina and blood-CSF barriers (choroid plexus and meninges), signaling within the neurovascular unit and elements of the brain fluid systems. It further discusses how brain barriers and brain fluid systems are impacted in CNS diseases, their role in disease progression and progress being made in treating such diseases.

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Section: Genetics and The Blood-brain Barriersmentioning

confidence: 99%

A year in review: brain barriers and brain fluids research in 2022

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Jones

Hamilton

et al. 2023

Fluids Barriers CNS

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“…Our previous gene chip study suggested that the ABCB1 gene was more highly expressed in the AMI than in the control group. The latest study found that ABCB1 was highly expressed in the vascular endothelium of the neocortex in patients with drug-resistant epilepsy, and the expression of ABCB1 was regulated by epigenetic marker [ 10 ].Nevertheless, few studies have investigated the role of ABCB1 in cardiovascular disease, especially in patients with AMI. ABCB1 may regulate coronary heart disease, and the expression of ABCB1 is closely related to inflammatory response and glucose metabolism.…”

Section: Introductionmentioning

confidence: 99%

Expression of ATP-binding cassette subfamily B member 1 gene in peripheral blood of patients with acute myocardial infarction

et al. 2022

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This study aimed to determine the amount of expression of the ATP-binding cassette subfamily B member 1 (ABCB1) gene chip as a prospective diagnostic marker for acute myocardial infarction (AMI) in a wide population . In the AMI and control groups, 113 patients with AMI and 83 persons with non-coronary artery disease were selected for peripheral venous leukocyte collection. Western blot and real-time polymerase chain reaction (RT-PCR) were employed to detect relative ABCB1 expression in both groups. The results showed that the ABCB1 transcription and protein levels in the AMI group were higher than in the control. The relative mRNA expression of ABCB1 was 0.26 (0.03–0.79) in the AMI group and 0.13 (0.01–0.52) in the control group (P < 0.05). The expression of the ABCB1 gene at the protein level in the AMI group was 1.65 times that in the control (P < 0.05). Further, the subjects in the AMI group were older (P < 0.001), had lower levels of high-density lipoprotein cholesterol (P = 0.038), and had higher incidence of type II diabetes mellitus (P = 0.003) compared with the control. Logistic regression analysis showed that the expression of ABCB1 in peripheral blood was correlated with the occurrence of AMI (P = 0.003). High ABCB1 expression, type II diabetes, and advanced age were found to serve as potential independent risk factors for AMI, with a 4.88-fold, 2.99-fold, and 2.63-fold increased risk of AMI. Overall, the high expression of ABCB1 in peripheral blood might be related to the occurrence of AMI.

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A novel epigenetic marker, Ten-eleven translocation family member 2 (TET2), is identified in the intractable epileptic brain and regulates ATP binding cassette subfamily B member 1 (ABCB1) in the blood–brain barrier

Cited by 2 publications

References 55 publications

A year in review: brain barriers and brain fluids research in 2022

A year in review: brain barriers and brain fluids research in 2022

Expression of ATP-binding cassette subfamily B member 1 gene in peripheral blood of patients with acute myocardial infarction

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