A novel electrospun nanofiber system with PEGylated paclitaxel nanocrystals enhancing the transmucus permeability and in situ retention for an efficient cervicovaginal cancer therapy

Duan, Huan; Chen, Haini; Qi, Chenrui; Lv, Fengmei; Wang, Jun; Liu, Yicheng; Liu, Zhepeng; Liu, Yu

doi:10.1016/j.ijpharm.2023.123660

Cited by 30 publications

(22 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tumors stand as the primary culprits behind cancer-related fatalities, and the process pf tumor formation and treatment is intricate (Duan et al, 2024). Recognizing the limitations of monotherapy, the development of dual-drug combinations has developed as a promising strategy to enhance therapeutic efficacy (Li, Liu, & Abdelhakim, 2022).…”

Section: Targeted Drug Delivery Systemsmentioning

confidence: 99%

Electrospun multi‐chamber core–shell nanofibers and their controlled release behaviors: A review

Liu,

Chen,

Lin

et al. 2024

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Core–shell structure is a concentric circle structure found in nature. The rapid development of electrospinning technology provides more approaches for the production of core–shell nanofibers. The nanoscale effects and expansive specific surface area of core–shell nanofibers can facilitate the dissolution of drugs. By employing ingenious structural designs and judicious polymer selection, specialized nanofiber drug delivery systems can be prepared to achieve controlled drug release. The synergistic combination of core–shell structure and materials exhibits a strong strategy for enhancing the drug utilization efficiency and customizing the release profile of drugs. Consequently, multi‐chamber core–shell nanofibers hold great promise for highly efficient disease treatment. However, little attention concentration is focused on the effect of multi‐chamber core–shell nanofibers on controlled release of drugs. In this review, we introduced different fabrication techniques for multi‐chamber core–shell nanostructures, including advanced electrospinning technologies and surface functionalization. Subsequently, we reviewed the different controlled drug release behaviors of multi‐chamber core–shell nanofibers and their potential needs for disease treatment. The comprehensive elucidation of controlled release behaviors based on electrospun multi‐chamber core–shell nanostructures could inspire the exploration of novel controlled delivery systems. Furthermore, once these fibers with customizable drug release profiles move toward industrial mass production, they will potentially promote the development of pharmacy and the treatment of various diseases.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

show abstract

Section: Targeted Drug Delivery Systemsmentioning

confidence: 99%

Electrospun multi‐chamber core–shell nanofibers and their controlled release behaviors: A review

Liu,

Chen,

Lin

et al. 2024

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

show abstract

“…Modified drug release is invariably a hot topic in pharmaceutics. 39–41 New excipients, new pharmaceuticals, and new strategies are continuously introduced into applications modifying the release behaviors of loaded drug molecules. 42–45 Biphasic release, as an advanced type of rate-controlled drug release, has demonstrated its value in treating several kinds of diseases with some commercial products.…”

Section: Introductionmentioning

confidence: 99%

“…57–61 Dissolution enhancements and biphasic controlled release would be useful to enhance their therapeutic effects while reducing the risk of excessive dosage to achieve the goal of “effective, safe and convenient” drug delivery. 41,62–66…”

Section: Introductionmentioning

confidence: 99%

Electrosprayed Eudragit RL100 nanoparticles with Janus polyvinylpyrrolidone patches for multiphase release of paracetamol

Zhou,

Pan,

Gong

et al. 2024

Nanoscale

View full text Add to dashboard Cite

show abstract

“…In order to better match the complex structure of the skin and accommodate a higher load of active substances in dressings, significant advancements have been made in electrospinning equipment. This progress has resulted in the transformation of traditional single-fluid electrospinning , into coaxial, , side-by-side, and multifluid electrospinning . Besides equipment enhancements, the incorporation of various types of nanofibers through a straightforward layer-by-layer assembly approach can yield composite fibers with multiple functionalities. , It has been shown that the multifluid spinning process is intricate due to challenges like electrostatic field superposition and multistrand material miscibility issues. , Layer-by-layer electrospinning not only sidesteps the complexities of multifluid processes but also allows for robust preparation.…”

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Accelerated Wound Healing by Electrospun Multifunctional Fibers with Self-Powered Performance

Zhang,

Wang,

Yuan

et al. 2024

Langmuir

View full text Add to dashboard Cite

Wound healing has been a persistent clinical challenge for a long time. Electrical stimulation is an effective therapy with the potential to accelerate wound healing. In this work, the self-powered electrospun nanofiber membranes (triples) were constructed as multifunctional wound dressings with electrical stimulation and biochemical capabilities. Triple was composed of a hydrolyzable inner layer with antiseptic and hemostatic chitosan, a hydrophilic core layer loaded with conductive AgNWs, and a hydrophobic outer layer fabricated by self-powered PVDF. Triple exhibited presentable wettability and acceptable moisture permeability. Electrical performance tests indicated that triple can transmit electrical signals formed by the piezoelectric effect to the wound. High antibacterial activities were observed for triple against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, with inhibition rates of 96.52, 98.63, and 97.26%, respectively. In vitro cell assays demonstrated that triple cells showed satisfactory proliferation and mobility. A whole blood clotting test showed that triple can enhance hemostasis. The innovative self-powered multifunctional fibers presented in this work offer a promising approach to addressing complications and expediting the promotion of chronic wound healing.

show abstract

A novel electrospun nanofiber system with PEGylated paclitaxel nanocrystals enhancing the transmucus permeability and in situ retention for an efficient cervicovaginal cancer therapy

Cited by 30 publications

References 52 publications

Electrospun multi‐chamber core–shell nanofibers and their controlled release behaviors: A review

Electrospun multi‐chamber core–shell nanofibers and their controlled release behaviors: A review

Electrosprayed Eudragit RL100 nanoparticles with Janus polyvinylpyrrolidone patches for multiphase release of paracetamol

Accelerated Wound Healing by Electrospun Multifunctional Fibers with Self-Powered Performance

Contact Info

Product

Resources

About