A novel electrochemical sensor based on magneto LDH/Fe3O4 nanoparticles @ glassy carbon electrode for voltammetric determination of tramadol in real samples

Mixed hemimicelle magnetic dispersive solid‐phase extraction using carbon‐coated magnetic nanoparticles for the determination of tramadol in urine samples

“…The analysis of tramadol in biomedical discipline targets a broad range of aims such as therapeutic drug monitoring, pharmacokinetic studies in order to investigate the drug bioavailability, bioequivalence tests to evaluate the effect of formulation parameters, toxicology, and forensic science. Various methods were reported for the determination of tramadol including chromatography [11][12][13][14][15][16][17][18], electrophoresis [19,20], and electrochemical methods [21]. Biological matrices containing a large amount of proteins, salts, and lipids are required to be cleaned-up prior to being coupled with the majority of analytical devices due to the clogging risk of the column [22][23][24].…”

Interpol review of controlled substances 2016–2019

“…Tramadol: 2016 Potentiometric selective electrodes designed for the electrochemical determination of tramadol hydrochloride in bulk, Pharmaceutical formulations (also applied to plasma and urine) [ 487 ]; cyclic voltammetry for the determination of tramadol (also paracetamol and caffeine) [ 488 ]; RP-HPLC method for the simultaneous analysis of tramadol hydrochloride and dicyclomine in bulk and tablet dosage form [ 489 ]; all-solid-state ion selective electrode for the determination of Tramadol Hydrochloride [ 490 ]; electrochemical sensor fabricated based on a glassy carbon electrode for determination of tramadol in pharmaceutical and biological samples [ 491 ]; all solid state polymeric membrane electrode for analysis of tramadol hydrochloride in pharmaceutical formulations [ 492 ]; UV spectrophotometric method for simultaneous determination of paracetamol and tramadol in paracetamol-tramadol tablets [ 493 ]; formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders as possible controlled release formulations [ 494 ]; colorimetric method for estimation of tramadol hydrochloride in pure and tablet dosage forms [ 495 ]; predictive pharmacokinetics of tramadol hydrochloride floating tablets [ 496 ]; 2017 electrochemical imprinted sensor for determination of tramadol by combination of a functionalized multiwall carbon nanotubes and a thin molecularly imprinted film [ 497 ]; RP-HPLC method for simultaneous quantitation of tramadol and aceclofenac [ 498 ]; voltammetric determination of tramadol [ 499 ]; electrochemical determination of tramadol and paracetamol [ 500 ]; review article on tramadol [ 501 ]; electrochemical sensors for the determination of tramadol hydrochloride in pharmaceutical formulations [ 502 ]; glassy carbon electrode for determination of warfarin and tramadol in pharmaceutical compounds [ 503 ]; anisotropic (spherical/hexagon/cube) silver nanoparticle embedded magnetic carbon nanosphere as platform for designing of tramadol imprinted polymer [ 504 ]; synthesis of phosphorylated derivatives of cis-tramadol and analysis by IR, NMR (H-1, C-13, P-31), mass spectra, and C, H, N [ 505 ]; development of controlled release matrix tablets of tramadol [ 506 ]; enantiomeric separation of tramadol by LC with fluorescence detection [ 507 ]; 2018 LC-MS/MS Quantification of Tramadol and Gabapentin Utilizing Solid Phase Extraction [ 508 ]; liquid-liquid microextraction combined with GC-FID for the quantification of methadone and tramadol [ 509 ]; sensor for the determination of tramadol in pharmaceutical and biological samples [ 510 ]; 15-year overview of increasing tramadol utilization and the impact of tramadol classificat...…”

Simultaneous voltammetric determination of tramadol and paracetamol exploiting glassy carbon electrode modified with FeNi3 nanoalloy in biological and pharmaceutical media

“…Studies introduced several techniques to co-detect these two drugs. [6] It should be noted that some disadvantages have been reported for many of these methods, including the need for more time, difficulty in pre-treatment of specimens, and the need for expensive interfering reagents, highlighting the necessity for development of rapid, sensitive and inexpensive strategy to successfully detect these drugs. [7][8][9][10][11][12][13] One of the recently effective methods to overcome these disadvantages is the use of electrochemical processes due to unique properties such as high selectivity and sensitivity, and the capacity in minimizing the interferences.…”