A novel electrochemical nanosensor based on NH2-functionalized multi walled carbon nanotubes for the determination of catechol-orto-methyltransferase inhibitor entacapone

Aftab, Saima; Özçelikay, Göksu; Kurbanoğlu, Sevinç; Shah, Afzal; Iftikhar, Faiza Jan; Özkan, Síbel A.

doi:10.1016/j.jpba.2018.11.050

Cited by 26 publications

(13 citation statements)

References 27 publications

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“…Nanomaterials-based electrochemical sensors are an emerging class of sensing tools that find applications in environmental monitoring, food analysis, and disease diagnostics. − Nanoparticles (NPs) of different sizes and shapes are mostly employed in the recognition layer of electrochemical sensors. Gold NPs are particularly used in electrochemical and colorimetric sensors due to their good electrical and optical properties. − The binding propensity of Au NPs with suitable ligands is utilized for the preparation of active surfaces for sensing applications. − …”

Section: Introductionmentioning

confidence: 99%

A Novel Electrochemical Nanosensor for the Simultaneous Sensing of Two Toxic Food Dyes

Shah

2020

ACS Omega

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This work reports for the first time the preparation and performance of a nanosensor for the simultaneous detection of metanil yellow and fast green, which are toxic food dyes. For the development of this sensitive platform, the surface of a glassy carbon electrode (GCE) was modified with calixarene and gold nanoparticles. The sensing ability of the designed nanosensor (calix8/Au NPs/GCE) was tested by cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy. The influence of a number of parameters was investigated for optimizing the conditions to achieve the best response of the target analytes. Due to the synergistic activity of calix[8]arene and Au nanoparticles, the calix8/Au NPs/GCE nanocomposite was found to significantly enhance the signals of the selected food dyes in comparison to bare GCE. Under optimized conditions, limits of detection for metanil yellow and fast green were found to be 9.8 and 19.7 nM, respectively, at the calix8/Au NPs/GCE. The designed sensing platform also demonstrated figures of merit when applied for the sensing of food dyes in real water and juice samples. Moreover, high percent recovery, reproducibility, and stability suggested applicability of the designed electrochemical platform for real sample analysis.

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Section: Introductionmentioning

confidence: 99%

A Novel Electrochemical Nanosensor for the Simultaneous Sensing of Two Toxic Food Dyes

Shah

2020

ACS Omega

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“…Nowadays, modification of the electrode surfaces with nanomaterials is method of choice for improving sensitivity, selectivity and precision. Carbon allotropes , conducting polymers , metal oxides , metal nanoparticles and their combinations are the most known modifiers for the achieving not only for highest sensitivity but also, satisfactory selectivity for trace analysis. Since their discovery in 1991 by Iijima, carbon nanotubes (CNTs) are very versatile materials because of their unique characteristics such as; chemical and thermal stability, conductivity, high surface area.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Isoniazid Drug in Various Matrix by Using CuO_x Decorated MW‐CNT Modified Glassy Carbon Electrode

Özdokur

2019

Electroanalysis

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Copper oxide decorated multi‐walled carbon nanotube (MWCNT) modified glassy carbon electrode (GCE) was prepared for determination of isoniazid (INZ) in various matrices. The electrochemical behavior of INZ was tested with the aid of Cyclic Voltammetry (CV) and quantitative experiments were performed by using Linear Sweep Voltammetry (LSV). Morphological and structural characterization of the modified electrode was performed by utilizing Scanning Electron Microscopy (SEM), X‐Ray Photoelectron Spectroscopy (XPS) while electrochemical characterization was performed by using CV and Electrochemical Impedance spectroscopy (EIS). The proposed sensor exhibited well defined anodic peak at 0.30 V for INZ at pH 6.0 medium. Under the optimum conditions, a linear relation between INZ concentration and peak current was observed in the range of 2.0×10−7 to 5.0×10−5 M. Limit of detection was calculated as 1.0×10−8 M and repeatability and accuracy was found as 5.60 % and 91.0 % for 5.0 10−7 M INZ by using 3 successive measurement, respectively. Then, the analytic performance of the electrode developed was tested by analyzing commercial tablets, artificial human serum and urine samples. The results indicated that satisfactory recoveries was observed for all issue.

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“…ETC is often used in combination with L‐dopa and C‐dopa to treat PD with wearing‐off symptoms. All three drugs exhibit electrochemical oxidation behavior on various solid state electrodes associated with their catecholic moieties [15–16, 27–29]. The DPV results show three well distinguished anodic peaks at potentials of 0.473, 0.604 and 0.906 V, corresponding to the oxidation of L‐dopa, ETC and C‐dopa, respectively (Figure 6).…”

Section: Resultsmentioning

confidence: 99%

“…Most of these methods offer good selectivity and a low detection limit, but cannot be widely applied because of the high cost, time-consuming, and some are tedious and needs pre-separation steps. Electrochemical methods offer another opportunity to determine ETC, as it is an electroactive compound, therefore electroanalytical methods based on the reduction of ETC on hanging drop mercury electrode [13][14], the oxidation of ETC on carbon paste electrode [15] or using multi-walled carbon nanotubes decorated on GCE [16] are developed. Highly selective and sensitive electrodes able to detect ETC in biological fluids, have yet to be developed.…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Poly‐o‐phenylenediamine Electrochemical Sensor for Entacapone

Radi

Abd-Ellatief

2021

Electroanalysis

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We have developed a molecularly imprinted polymer (MIP) electrochemical sensor for entacapone (ETC) based on an electropolymerised polyphenylenediamine (Po‐PD) on a glassy carbon electrode (GCE) surface. The direct electropolymerisation of the o‐phenylenediamine monomer (o‐PD) was carried out with ETC as a template. The steps of electropolymerization process, template removal and binding of the analyte were tested by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) using [Fe(CN)6]3−/[Fe(CN)6]4 − as a redox probe. The operation of the sensor has been investigated by differential pulse voltammetry (DPV). Under optimal experimental conditions, the response of the DPV was linearly proportional to the ETC concentration between 1.0×10−7 and 5.0×10−6 M ETC with a limit of detection (LOD) of 5.0×10−8 M. The developed sensor had excellent selectivity without detectable cross‐reactivity for levodopa and carbidopa. The MIP sensor was successfully used to detect ETC in spiked human serum samples.

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A novel electrochemical nanosensor based on NH2-functionalized multi walled carbon nanotubes for the determination of catechol-orto-methyltransferase inhibitor entacapone

Cited by 26 publications

References 27 publications

A Novel Electrochemical Nanosensor for the Simultaneous Sensing of Two Toxic Food Dyes

A Novel Electrochemical Nanosensor for the Simultaneous Sensing of Two Toxic Food Dyes

Voltammetric Determination of Isoniazid Drug in Various Matrix by Using CuO_x Decorated MW‐CNT Modified Glassy Carbon Electrode

Molecularly Imprinted Poly‐o‐phenylenediamine Electrochemical Sensor for Entacapone

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A novel electrochemical nanosensor based on NH2-functionalized multi walled carbon nanotubes for the determination of catechol-orto-methyltransferase inhibitor entacapone

Cited by 26 publications

References 27 publications

A Novel Electrochemical Nanosensor for the Simultaneous Sensing of Two Toxic Food Dyes

A Novel Electrochemical Nanosensor for the Simultaneous Sensing of Two Toxic Food Dyes

Voltammetric Determination of Isoniazid Drug in Various Matrix by Using CuOx Decorated MW‐CNT Modified Glassy Carbon Electrode

Molecularly Imprinted Poly‐o‐phenylenediamine Electrochemical Sensor for Entacapone

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Voltammetric Determination of Isoniazid Drug in Various Matrix by Using CuO_x Decorated MW‐CNT Modified Glassy Carbon Electrode