A novel electrically conductive and biodegradable composite made of polypyrrole nanoparticles and polylactide

Shi, Gaoquan; Rouabhia, Mahmoud; Wang, Zhaoxu; Dao, Lê H.; Zhang, Ze

doi:10.1016/j.biomaterials.2003.09.032

Cited by 327 publications

(239 citation statements)

References 42 publications

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“…Shi et al (2007) found the application of an electrical field to conductive biodegradable PPy-PLA membranes to be an effective approach to upregulate the mitochondrial activity of human skin fibroblasts. These researchers also fabricated a conductive biodegradable composite material made of PPy nanoparticles and poly(D,L-lactide), applied electrical stimulation after seeding fibroblasts on them and found similar upregulations (Shi et al, 2004). Jeong et al (2008) fabricated nanofibrous scaffolds containing PANI and poly(L-lactideco-ε-caprolactone) and investigated the behaviour of human dermal fibroblasts, NIH-3T3 fibroblasts and C2C12 myoblasts on this scaffold.…”

Section: Application Of Electrical Stimulation In Nerve Tissue Enginementioning

confidence: 99%

“…Ester linkages can be cleaved by enzymes in vivo and the resultant polymer had the unique properties of being both electrically conducting and biodegradable (Rivers et al, 2002). Studies by Shi et al (2004) also introduced the biodegradation property to conductive polymers by blending them with suitable degradable polymers. On the other hand, Huang et al (2007) fabricated a novel electroactive biodegradable composite containing polylactide as the biodegradable segment and the low molecular weight aniline pentamer as electroactive segment.…”

Section: Conducting Polymersmentioning

confidence: 99%

“…The high degree of conjugation in the molecular backbone of PPy makes it very rigid, insoluble and poorly processable. It is therefore very difficult to be used alone as a structural material and must be optimized and transformed into a mechanically manageable and processable form (Shi et al, 2004). Wong et al (1994) synthesized optically transparent PPy thin films and studied them for mammalian cell culture.…”

Section: Polypyrrolementioning

confidence: 99%

See 2 more Smart Citations

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

603

389

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Among the numerous attempts to integrate tissue engineering concepts into strategies to repair nearly all parts of the body, neuronal repair stands out. This is partially due to the complexity of the nervous anatomical system, its functioning and the inefficiency of conventional repair approaches, which are based on single components of either biomaterials or cells alone. Electrical stimulation has been shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering. In this review, by taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, we discuss the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering. Other electrospun, composite, conductive scaffolds, such as PANI/gelatin and PPy/poly(ε-caprolactone), with or without electrical stimulation, are also discussed. Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed.

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Section: Application Of Electrical Stimulation In Nerve Tissue Enginementioning

confidence: 99%

Section: Conducting Polymersmentioning

confidence: 99%

Section: Polypyrrolementioning

confidence: 99%

See 1 more Smart Citation

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

603

389

View full text Add to dashboard Cite

show abstract

“…The surface resistivity of the PPy/PDLLA membrane with 3% PPy was as high as 1 x10 3 Ω/square. The electrical stability was significantly better in the PPy/PDLLA composite than in the PPy coated polyester fabrics and sustained a biologically meaningful electrical conductivity in a typical cell culture environment for 1000h [87] . This composite was fabricated into NCs for further neuroregeneration studies.…”

Section: 43incorporation Of Other Dopants and Compositesmentioning

confidence: 97%

Bio‐Interface of Conducting Polymer‐Based Materials for Neuroregeneration

Weng

Diao

et al. 2015

Adv Materials Inter

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Nerve system diseases like Parkinson's disease, Huntington's disease, Alzheimer's disease, etc. seriously affect thousands of patients' lives every year, making them suffer from pains and inconvenience. Recently, biointerfaces between neural cells/tissues and polymer based biomaterials attracted worldwide attention due to the ability of polymer based biomaterials to serve as nerve conduits, drug carriers and neurites guidance platform in neuroregeneration. The role that bio-interface played and the way it interacted with neural tissues and cells have been thoroughly investigated by the researchers. In this paper we mainly focus on reviewing the bio-interface between nerve tissues/cells and advanced functional biocompatible polymers, such as conducting polymers and advanced carbon composite materials. These advanced polymers can provide combined interfacial stimulations including interfacial external neurotrophic factors (NTFs) delivery, electrical stimulation, surface guidance and molecules decoration to lesion cells and tissues to promote neuroregeneration in vitro and in vivo, and have contributed greatly to nerve diseases therapy. At the end of this review, the criteria of polymer based biomaterials utilized in neuroregeneration are summarized and the perspectives for future development of bio-interfaces are also discussed. Nerve system diseases like Parkinson's disease, Huntington's disease and Alzheimer's disease etc. seriously affect thousands of patients' lives every year, making the patients suffer from pains and inconvenience brought about by these diseases. Recently, bio-interface between neural cells/tissues and polymer based biomaterials attracted worldwide attention due to the ability of polymer based biomaterials to serve as nerve conduits, drug carrier and neurites guidance platform in neuroregeneration. The role that bio-interface played and the way it interacted with neural tissues and cells have been thoroughly investigated by the researchers.In this paper we mainly focus on reviewing bio-interface between nerve tissues/cells and advanced functional biocompatible polymers, such as conducting polymers and advanced carbon composites materials.. These advanced polymers can provide combined interfacial stimulations including interfacial NTFs delivery, electrical stimulation, surface guidance and molecules decoration to lesion cells and tissues to promote neuroregeneration in vitro and in vivo, and have contributed greatly to nerve diseases therapy. At the end of this review, the criteria of polymer based biomaterials utilized in neuroregeneration are summarized and the perspectives for future development of bio-interfaces are also discussed.

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“…Conducting polymers have stimulated the development of many biosensors for in vivo applications, including all-polymer integrated electronic circuits [67]. As general requirements the biomedical sensor implanted in the body should be biocompatible, passive, and wireless.…”

Section: Development Of Novel Biodegradable Polymes and Blends Based mentioning

confidence: 99%

Nanomembranes and Nanofibers from Biodegradable Conducting Polymers

et al. 2013

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Abstract:This review provides a current status report of the field concerning preparation of fibrous mats based on biodegradable (e.g., aliphatic polyesters such as polylactide or polycaprolactone) and conducting polymers (e.g., polyaniline, polypirrole or polythiophenes). These materials have potential biomedical applications (e.g., tissue engineering or drug delivery systems) and can be combined to get free-standing nanomembranes and nanofibers that retain the better properties of their corresponding individual components. Systems based on biodegradable and conducting polymers constitute nowadays one of the most promising solutions to develop advanced materials enable to cover aspects like local stimulation of desired tissue, time controlled drug release and stimulation of either the proliferation or differentiation of various cell types. The first sections of the review are focused on a general overview of conducting and biodegradable polymers most usually employed and the explanation of the most suitable techniques for preparing nanofibers and nanomembranes (i.e., electrospinning and spin coating). Following sections are organized according to the base conducting polymer (e.g., Sections 4-6 describe hybrid systems having aniline, pyrrole and thiophene units, respectively). Each one of these sections includes specific subsections dealing with applications in a nanofiber or nanomembrane form. Finally, miscellaneous systems and concluding remarks are given in the two last sections. OPEN ACCESSPolymers 2013, 5 1116

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A novel electrically conductive and biodegradable composite made of polypyrrole nanoparticles and polylactide

Cited by 327 publications

References 42 publications

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Bio‐Interface of Conducting Polymer‐Based Materials for Neuroregeneration

Nanomembranes and Nanofibers from Biodegradable Conducting Polymers

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