A Novel DNA Probe Based on Molecularly Imprinted Polymer Modified Electrode for the Electrochemical Monitoring of DNA

Muti, Mihrican; Soysal, Mert; Nacak, Fatma Merve; Gençdağ, Kübra; Karagözler, A. Ersin

doi:10.1002/elan.201400672

Cited by 19 publications

(5 citation statements)

References 42 publications

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“…A molecularly imprinted electrochemoluminescence sensor for ultrasensitive HIV-1 gene detection using EuS nanocrystals as luminophore was developed [ 190 ]. Methylene blue imprinted polyvinyl pyridine polymer modified carbon paste electrodes were applied for the electrochemical monitoring of DNA [ 196 ].…”

Section: Formation Of Mips Imprinted By Proteins and By Other Largmentioning

confidence: 99%

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

2021

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Recent challenges in biomedical diagnostics show that the development of rapid affinity sensors is very important issue. Therefore, in this review we are aiming to outline the most important directions of affinity sensors where polymer-based semiconducting materials are applied. Progress in formation and development of such materials is overviewed and discussed. Some applicability aspects of conducting polymers in the design of affinity sensors are presented. The main attention is focused on bioanalytical application of conducting polymers such as polypyrrole, polyaniline, polythiophene and poly(3,4-ethylenedioxythiophene) ortho-phenylenediamine. In addition, some other polymers and inorganic materials that are suitable for molecular imprinting technology are also overviewed. Polymerization techniques, which are the most suitable for the development of composite structures suitable for affinity sensors are presented. Analytical signal transduction methods applied in affinity sensors based on polymer-based semiconducting materials are discussed. In this review the most attention is focused on the development and application of molecularly imprinted polymer-based structures, which can replace antibodies, receptors, and many others expensive affinity reagents. The applicability of electrochromic polymers in affinity sensor design is envisaged. Sufficient biocompatibility of some conducting polymers enables to apply them as “stealth coatings” in the future implantable affinity-sensors. Some new perspectives and trends in analytical application of polymer-based semiconducting materials are highlighted.

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Section: Formation Of Mips Imprinted By Proteins and By Other Largmentioning

confidence: 99%

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

2021

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“…MIP-formation is a highly multidisciplinary approach, which involves polymer and organic chemistry and nanotechnology [ 169 , 170 ]. It should be noted that DNA [ 27 ] can also be entrapped [ 24 ] or molecularly imprinted [ 171 , 172 , 173 ] within conducting polymers and applied for bioanalytical purposes. Therefore, a lot of researchers are targeted towards the replacement of biomolecules, such as receptors, antibodies, DNA-based sequences and DNA-aptamers, with molecularly imprinted polymer-based structures or by artificial receptors [ 174 ].…”

Section: Mips Structures Imprinted By Biomolecules Of High Molecular ...mentioning

confidence: 99%

Electrochemically Deposited Molecularly Imprinted Polymer-Based Sensors

Ramanavičius

Morkvėnaitė-Vilkončienė

Samukaitė-Bubnienė

et al. 2022

Sensors

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This review is dedicated to the development of molecularly imprinted polymers (MIPs) and the application of MIPs in sensor design. MIP-based biological recognition parts can replace receptors or antibodies, which are rather expensive. Conducting polymers show unique properties that are applicable in sensor design. Therefore, MIP-based conducting polymers, including polypyrrole, polythiophene, poly(3,4-ethylenedioxythiophene), polyaniline and ortho-phenylenediamine are frequently applied in sensor design. Some other materials that can be molecularly imprinted are also overviewed in this review. Among many imprintable materials conducting polymer, polypyrrole is one of the most suitable for molecular imprinting of various targets ranging from small organics up to rather large proteins. Some attention in this review is dedicated to overview methods applied to design MIP-based sensing structures. Some attention is dedicated to the physicochemical methods applied for the transduction of analytical signals. Expected new trends and horizons in the application of MIP-based structures are also discussed.

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“…MIP-formation needs knowledge in organic and polymer chemistry [160,161]. It was demonstrated that DNA [29] can be entrapped [26] and molecularly imprinted [162][163][164] within CP-based layers. Therefore, some investigations are dedicated to replace direct application of DNA-based sequences in analytical systems [165].…”

Section: Polymers Imprinted By Proteins and Large Biological Compoundsmentioning

confidence: 99%