“…Naltrexone reduces ethanol consumption in both low ethanol consuming rats (Stromberg et al, 1998a) and high ethanol consuming rats (Nielsen et al, 2008;Simms et al, 2008). However, the effects of naltrexone on ethanol consumption are non-selective as fat, sucrose and water intake are also reduced (Corwin & Wojnicki, 2009;Nielsen et al, 2008;Rao et al, 2008;Simms et al, 2008;Wong et al, 2009). Also, naltrexone reduces alcohol-and cueinduced reinstatement, but not foot-shock stress-induced reinstatement of ethanol-seeking in rodents (Ciccocioppo et al, 2002a;Le et al, 1999;Liu & Weiss, 2002).…”