A novel covalently crosslinked gel of alginate and silane with the ability to form bone‐like apatite

Hosoya, Kayo; Ohtsuki, Chikara; Kawai, Takeshi; Kamitakahara, Masanobu; Ogata, Shinichi; Miyazaki, Toshiki; Tanihara, Masao

doi:10.1002/jbm.a.30189

Cited by 60 publications

(46 citation statements)

References 25 publications

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“…We have reported an apatite-alginate composite using SBF (Hosoya et al 2004). It is known that alginate can act as a scaffold material for the repair of skin and nerves (Suzuki et al 1998(Suzuki et al , 1999.…”

Section: Bioactive Coatingmentioning

confidence: 99%

Bioactive ceramic-based materials with designed reactivity for bone tissue regeneration

Ohtsuki

Kamitakahara

Miyazaki

2009

J. R. Soc. Interface.

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144

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Bioactive ceramics have been used clinically to repair bone defects owing to their biological affinity to living bone; i.e. the capability of direct bonding to living bone, their so-called bioactivity. However, currently available bioactive ceramics do not satisfy every clinical application. Therefore, the development of novel design of bioactive materials is necessary. Bioactive ceramics show osteoconduction by formation of biologically active bone-like apatite through chemical reaction of the ceramic surface with surrounding body fluid. Hence, the control of their chemical reactivity in body fluid is essential to developing novel bioactive materials as well as biodegradable materials. This paper reviews novel bioactive materials designed based on chemical reactivity in body fluid.

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Section: Bioactive Coatingmentioning

confidence: 99%

Bioactive ceramic-based materials with designed reactivity for bone tissue regeneration

Ohtsuki

Kamitakahara

Miyazaki

2009

J. R. Soc. Interface.

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144

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“…Based on this idea, a composite composed of alginate and HA was prepared by soaking alginate modified with SiOH groups and Ca 2+ ions in SBF. 56) The modification with SiOH groups works not only for the induction of HA nucleation but also crosslinking of the alginate. As alginate is a biodegradable polymer, the resultant HA/alginate composite is expected to show both bioactivity and biodegradability, and to be useful as a scaffold for the bone regeneration.…”

Section: )53)mentioning

confidence: 99%

Preparation of highly functional artificial bones using the properties of calcium phosphates

Kamitakahara¹

2011

J. Ceram. Soc. Japan

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Ceramics can not only be used to create tools for use in our daily life but also can contribute to the health of our body. As ceramics composed of calcium phosphates show a high biological affinity to bone tissue, they have been used for the repair and regeneration of bone. Although conventional sintered hydroxyapatite (HA) ceramics and tricalcium phosphate (TCP) ceramics are both widely used, the ability of these materials to regenerate the bone is insufficient and their use remains limited. As calcium phosphate is an inorganic component of bone, highly functional artificial bones could be obtained if we made best use of the properties of calcium phosphates. This paper describes methods to improve the functionality of artificial bones based on calcium phosphates.

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“…Calcium cross-linked A hydrogel is considered a promising material as a delivery matrix for drugs and proteins, since its gel microspheres form readily in aqueous solutions at room temperature, eliminating the need for harsh organic solvents, thereby maintaining the bioactivity of proteins in the process of loading into the microspheres [11,12]. In addition, calcium cross-linked A hydrogel is degradable under physiological conditions [13,14], which makes A stand out as an attractive candidate material for the protein carrier and bone regeneration [15][16][17]. However, the major disadvantages of A microspheres is their low loading efficiency and also rapid release of proteins owing to the meshlike networks of the gel [18].…”

Section: Introductionmentioning

confidence: 99%

In situ preparation and protein delivery of silicate–alginate composite microspheres with core-shell structure

Fan

Gelinsky

et al. 2011

J. R. Soc. Interface.

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The efficient loading and sustained release of proteins from bioactive microspheres remain a significant challenge. In this study, we have developed bioactive microspheres which can be loaded with protein and then have a controlled rate of protein release into a surrounding medium. This was achieved by preparing a bioactive microsphere system with core-shell structure, combining a calcium silicate (CS) shell with an alginate (A) core by a one-step in situ method. The result was to improve the microspheres' protein adsorption and release, which yielded a highly bioactive material with potential uses in bone repair applications. The composition and the core-shell structure, as well as the formation mechanism of the obtained CS -A microspheres, were investigated by X-ray diffraction, optical microscopy, scanning electron microscopy, energy dispersive spectrometer dot and line-scanning analysis. The protein loading efficiency reached 75 per cent in CS -A microspheres with a core-shell structure by the in situ method. This is significantly higher than that of pure A or CS -A microspheres prepared by non-in situ method, which lack a core-shell structure. CS -A microspheres with a core-shell structure showed a significant decrease in the burst release of proteins, maintaining sustained release profile in phosphate-buffered saline (PBS) at both pH 7.4 and 4.3, compared with the controls. The protein release from CS -A microspheres is predominantly controlled by a Fickian diffusion mechanism. The CS -A microspheres with a core-shell structure were shown to have improved apatite-mineralization in simulated body fluids compared with the controls, most probably owing to the existence of bioactive CS shell on the surface of the microspheres. Our results indicate that the core-shell structure of CS -A microspheres play an important role in enhancing protein delivery and mineralization, which makes these composite materials promising candidates for application in bone tissue regeneration.

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A novel covalently crosslinked gel of alginate and silane with the ability to form bone‐like apatite

Cited by 60 publications

References 25 publications

Bioactive ceramic-based materials with designed reactivity for bone tissue regeneration

Bioactive ceramic-based materials with designed reactivity for bone tissue regeneration

Preparation of highly functional artificial bones using the properties of calcium phosphates

In situ preparation and protein delivery of silicate–alginate composite microspheres with core-shell structure

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