A novel continuous colour mapping approach for visualization of facial skin hydration and transepidermal water loss for four ethnic groups

Voegeli, R.; Rawlings, A. V.; Séroul, Pierre; Summers, Beverley

doi:10.1111/ics.12265

Cited by 43 publications

(58 citation statements)

References 27 publications

(49 reference statements)

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“…Biophysical parameters are strongly influenced by intrinsic and extrinsic factors like age, sex, race, circadian rhythm, season, exercise and acclimatization period; therefore data collection is inherently difficult to standardize. For TEWL, open measurement chambers are more vulnerable to environmental influences than are closed chambers; condenser closed chambers seem to be the most sensitive TEWL system, but this device type was not used in rosacea.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive objective skin measurement methods for rosacea assessment: a systematic review

et al. 2019

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Summary Background Rosacea assessment and therapy monitoring can be challenging to standardize, as most clinical evaluation systems are prone to interobserver variability and not always validated. Therefore, objective, reliable and preferably noninvasive measurement tools are needed. Objectives To give insight into available noninvasive imaging techniques and biophysical methods in rosacea by performing a systematic review. Methods PubMed, Embase, Cochrane and Web of Science databases were searched until 1 September 2018 in accordance with PRISMA guidelines, to identify studies providing original data about objective noninvasive imaging and/or biophysical skin measurement techniques for diagnosis, assessing severity or therapy monitoring of adult patients with cutaneous facial rosacea. Risk of bias of included articles was assessed with the Cochrane Risk of Bias tool, Quality in Prognosis Studies tool, and the Newcastle–Ottawa Scale. Results A total of 78 studies were included, describing 14 imaging and biophysical methods. Widespread information about (sub)surface cutaneous morphology and functionality was obtained. Methodological study quality was relatively low and interstudy outcome variability was large. Several tools show promising value in research settings: for treatment follow‐up Demodex mites are countable with reflectance confocal microscopy, spectrometry can quantify erythema, and rosacea severity could be objectified with skin hydration‐ and transepidermal water loss measurements. Conclusions This systematic review describes the spectrum of noninvasive imaging and biophysical methods in rosacea assessment, giving multifaceted information about structure and properties of rosacea skin, especially useful for research purposes. Larger studies with good methodological quality are needed to create validated protocols for further implementation into research. What's already known about this topic? Rosacea is a chronic inflammatory skin disease with a variety of clinical manifestations. Most clinical evaluation systems are subjective, not always validated, and subsurface skin processes remain unnoticed. Currently, different types of noninvasive measurement tools are available for rosacea assessment and therapy monitoring, but a comprehensive overview is lacking. What does this study add? Seventy‐eight publications were included, describing 14 imaging and biophysical tools, providing a wide range of information about rosacea skin morphology and functionality. Reflectance confocal microscopy and spectrometry are especially promising in therapy monitoring and skin barrier measurements for rosacea severity assessment. Larger studies with better methodological quality are needed to create validated protocols for implementation into research.

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Section: Discussionmentioning

confidence: 99%

Noninvasive objective skin measurement methods for rosacea assessment: a systematic review

et al. 2019

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“…At the bottom of an internal cavity (an open chamber of a 1 cm ∅, 8 mm in depth), an electronic probe records the variation in Relative Humidity (RH) %, further expressed as g/m 2 /h after its calibration by the supplier (GPOWER, Seoul, South Korea). It is noteworthy that the latter found highly significant statistical correlations (r ranging 0.84-0.92, P < 0.001 and below), on different skin sites of 200 healthy Korean subjects of both genders, between the GPSkin Barrier â system and with the CM825 Corneometer â (SC's hydration) or the TM300 Tewameter â (TEWL), both instruments being marketed by the Courage and Khazaka TM company (K€ oln, Germany) [11,12].…”

Section: Methodsmentioning

confidence: 99%

“…Two different instruments were then successively used to: (i) determine the water content of the outermost layers of the stratum corneum (SC) or (ii) quantify the amount of water that insensibly crosses the epidermal structures (the Trans‐Epidermal Water Loss – TEWL), supplied by a rich dermal water reservoir. The latter results from both a dense blood network that diffused water and the high potency of dermal proteins (Collagen, Elastin, Glycosaminoglycan’s/GAG’s etc.)…”

Section: Introductionmentioning

confidence: 99%

“…Two different instruments were then successively used [11,12] to: (i) determine the water content of the outermost layers of the stratum corneum (SC) or (ii) quantify the amount of water that Correspondence: Frederic Flament, L'Or eal Research and Innovation, 9 Rue Pierre Dreyfus 92110, Clichy, France. Tel: +33 149795334; fax: +33 149795142; e-mail: frederic.flament@rd.loreal.com insensibly crosses the epidermal structures (the Trans-Epidermal Water Loss -TEWL), supplied by a rich dermal water reservoir.…”

Section: Introductionmentioning

confidence: 99%

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Synchronized in vivo measurements of skin hydration and trans‐epidermal water loss. Exploring their mutual influences

Caberlotto

Cornillon

Njikeu

et al. 2019

Intern J of Cosmetic Sci

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Objective To explore the relationship between skin surface hydration and Trans‐Epidermal Water Loss (TEWL) when simultaneously measured. Methods Six circular skin areas of the forearms (3 per forearm, 3 cm in diameter) of 12 Caucasian women were used as models. 4 prototypes of formulae of different compositions containing glycerol at different concentrations 7%, 10% and 40% were used as models of hydrating products. One formula (glycerol‐free) was used as control vehicle. Standardized applications of formulae (2 mg/cm2) were performed on 5 skin sites chosen at random, the other being left as bare/control. A recently marketed instrumental device that records the skin surface hydration and TEWL on a small skin area in a simultaneous manner was used. Measurements were carried out at T0 (pre‐application), at 1 h (T1) and 5 h (T5) post applications on two close sites within the 6 defined areas of both forearms. Results The new instrumental device allowed to clearly differentiate the 5 formulae (i.e. 7% vs. 10%) with regard the dose effect brought by glycerol (7%, 10%, 40%) and to record their lingering effects at T1 and T5. Both parameters were found significantly and negatively correlated, i.e. the higher the skin hydration, the lower the TEWL. The 40% concentration of glycerol, that leads to the highest skin hydration, brings a drop in the TEWL by about a two‐fold factor. Skin hydration of bare skin and control/vehicle sites showed minor and non‐significant changes along 5 h. Instead, the control/ vehicle slowed down the TEWL to a slight extent. Conclusion The use of this new instrumental device shed a new light on the mutual and inverse relationships between skin hydration and TEWL. Results suggest that, at high concentration, glycerol leads to largely increase the water content of both epidermal and dermal compartments, possibly leading to structural changes in the skin relief.

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“…Efforts have also been directed at overcoming the limitation of single‐point measurements given by TEWL and electrical methods for estimating SC hydration. Information on the heterogeneity of the status and hydration of the skin barrier was obtained by imaging the skin with contact‐based capacitance sensors and by interpolating single‐point measurements to generate continuous colour maps . Another approach to offer a more thorough evaluation of the skin barrier could be to combine macroscopic assessments with biophysical analysis techniques with the assessment of molecular markers of inflammation with skin molecular diagnostic tests, such as Transdermal Analysis Patch .…”

Section: Future Perspectives On the Use Of Noninvasive Techniques Formentioning

confidence: 99%

Noninvasive analysis and minimally invasive in vivo experimental challenges of the skin barrier

Erp

Peppelman

Falcone

2018

Experimental Dermatology

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In this review, we aim to give a concise and selective overview of noninvasive biophysical analysis techniques for skin barrier analysis (transepidermal water loss, electrical methods, confocal Raman microspectroscopy, sebumeter, reflectance spectrophotometry, tristimulus colorimetry, diffuse reflectance spectroscopy and reflectance confocal microscopy), including advantages and limitations. Rather than giving an exhaustive description of the many techniques currently available, we show the usefulness of a representative selection of techniques in the functional and morphological evaluation of the skin barrier. Furthermore, we introduce human minimally invasive skin challenging models as a means to study the mechanisms regulating skin homoeostasis and disease and subsequently show how biophysical analysis techniques can be combined with these in vivo skin challenging models in the functional and morphological evaluation of the skin barrier in healthy human skin. We are convinced that the widespread application of biophysical analysis techniques in dermatological practice and in cosmetic sciences will prove invaluable in offering personalized and noninvasive skin treatment solutions. Furthermore, combining the human in vivo challenging models with these novel noninvasive techniques will provide valuable methodology and tools for detailed characterization of the skin barrier in health and disease.

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A novel continuous colour mapping approach for visualization of facial skin hydration and transepidermal water loss for four ethnic groups

Cited by 43 publications

References 27 publications

Noninvasive objective skin measurement methods for rosacea assessment: a systematic review

Noninvasive objective skin measurement methods for rosacea assessment: a systematic review

Synchronized in vivo measurements of skin hydration and trans‐epidermal water loss. Exploring their mutual influences

Noninvasive analysis and minimally invasive in vivo experimental challenges of the skin barrier

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