A novel compound from celery seed with a bactericidal effect against &lt;I&gt;Helicobacter pylori&lt;/I&gt;

Zhou, Yong; Taylor, Brian F.; Smith, Thomas J.; Liu, Zhongping; Clench, Malcolm R.; Davies, Noel W.; Rainsford, K. D.

doi:10.1211/jpp/61.08.0011

Cited by 18 publications

(18 citation statements)

References 54 publications

(48 reference statements)

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“…In contrast, the Indian derived extracts appear to have little or no effect against Campylobacter jejuni or E. coli, but did significantly inhibit the growth of Helicobacter pylori (Zhou et al 2009). Furthermore, a purified component of the Indian derived celery seed extracts had potent bactericidal effects against H. pylori; the minimum inhibitory concentration and minimum bactericidal concentration were 3.15 mg/ml and 6.25-12.5 mg/ml, respectively, activity comparable in these assays to tetracycline.…”

Section: Efficacy Of Cse As An Antimicrobial Agentmentioning

confidence: 89%

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Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Powanda¹,

Whitehouse

Rainsford

2015

Progress in Drug Research

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Celery preparations have been used extensively for several millennia as natural therapies for acute and chronic painful or inflammatory conditions. This chapter reviews some of the biological and chemical properties of various celery preparations that have been used as natural remedies. Many of these have varying activities and product qualities. A fully standardized celery preparation has been prepared known as an alcoholic extract of the seeds of a plant source derived from northern India. This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis. CSE can also reduce existing inflammation in rats. CSE has also been shown to provide analgesia in two model systems. CSE, in addition to acting as an analgesic and inflammatory agent, has been shown to protect against and/or reduce gastric irritation caused by NSAIDs, as well as act synergistically with them to reduce inflammation. The CSE was fractionated by organic solvent extractions, then subjected to column chromatography followed by HPLC and was characterized by mass spectrometry. This yielded a purified component that had specific inhibitory effects on Helicobacter pylori but was not active against Campylobacter jejuni or Escherichia coli. Additionally, toxicology studies did not reveal any clear signs of toxicity at doses relevant to human use. Also, unlike many dietary supplements, the available data suggest that CSE does not significantly affect the p450 enzyme systems and thus is less likely to alter the metabolism of drugs the individual may be taking. CSE may be a prototype of a natural product that can be used therapeutically to treat arthritis and other inflammatory diseases.

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Section: Efficacy Of Cse As An Antimicrobial Agentmentioning

confidence: 89%

“…7). The results appeared to rule out mechanisms that operated solely by loss of membrane integrity or inhibition of protein or nucleic acid synthesis (Zhou et al 2009). …”

Section: Efficacy Of Cse As An Antimicrobial Agentmentioning

confidence: 98%

Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Powanda¹,

Whitehouse

Rainsford

2015

Progress in Drug Research

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“…This had led to severe problems in patients during or after treatment outcomes. Though there is certainly cause for concern, it is unfair to pass judgement on the Cameroon TM healing systems on the basis of their worst outcomes; concerns about romanticising the traditional practices have to be taken seriously (Nkongmeneck et al, 2007;Zhou et al, 2009) …”

Section: Limiting Factors Of Tm Practice Collaboration In Cameroonmentioning

confidence: 99%

Traditional Medicine: Past, present and future research and development prospects and integration in the National Health System of Cameroon

Fokunang

Ndikum²,

Tabi³

et al. 2011

Afr. J. Trad. Compl. Alt. Med.

199

128

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Traditional medicine refers to health practices, approaches, knowledge and beliefs incorporating plant, animal and mineral based medicines, spiritual therapies, manual techniques and exercises, applied singularly or in combination to treat, diagnose and prevent illnesses or maintain well-being. In the last decade traditional medicine has become very popular in Cameroon, partly due to the long unsustainable economic situation in the country. The high cost of drugs and increase in drug resistance to common diseases like malaria, bacteria infections and other sexually transmitted diseases has caused the therapeutic approach to alternative traditional medicine as an option for concerted search for new chemical entities (NCE). The World Health Organisation (WHO) in collaboration with the Cameroon Government has put in place a strategic platform for the practice and development of TM in Cameroon. This platform aims at harmonizing the traditional medicine practice in the country, create a synergy between TM and modern medicine and to institutionalize a more harmonized integrated TM practices by the year 2012 in Cameroon. An overview of the practice of TM past, present and future perspectives that underpins the role in sustainable poverty alleviation has been discussed. This study gives an insight into the strategic plan and road map set up by the Government of Cameroon for the organisational framework and research platform for the practice and development of TM, and the global partnership involving the management of TM in the country.

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“…Nigella sativa seeds contain essential oils such as thymoquinone, dihydrothymoquinone and terpenes, that may exercise their antimicrobial activity by disrupting the lipid structure of the cell membrane (Salem et al, 2010). (Piperaceae), widely used in folk medicine in tropical and subtropical South American countries and known for their anti-inflammatory and anti-ulcer action (Quilez et al, 2010); 'compound with anti-Helicobacter activity', extracted from celery (Apium graveolens) seeds (Zhou et al, 2009); and phenolic acid derivatives, acylglycoflavonoids and condensed tannins from Davilla elliptica and Davilla nitida (Kushima et al, 2009). These include crude methanol extract of the leaf of Allium ascalonicum (Adeniyi & Anyiam, 2004); flavonoid constituents of herbal medicines (Shin et al, 2005), such as the ones isolated from the leaves of Piper carpunya Ruiz & Pav.…”

Section: Phytotherapymentioning

confidence: 99%

Alternative therapies for Helicobacter pylori: probiotics and phytomedicine

Vítor

Vale

2011

FEMS Immunol Med Microbiol

102

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Helicobacter pylori is a common human pathogen infecting about 30% of children and 60% of adults worldwide and is responsible for diseases such as gastritis, peptic ulcer and gastric cancer. Treatment against H. pylori is based on the use of antibiotics, but therapy failure can be higher than 20% and is essentially due to an increase in the prevalence of antibiotic-resistant bacteria, which has led to the search for alternative therapies. In this review, we discuss alternative therapies for H. pylori, mainly phytotherapy and probiotics. Probiotics are live organisms or produced substances that are orally administrated, usually in addition to conventional antibiotic therapy. They may modulate the human microbiota and promote health, prevent antibiotic side effects, stimulate the immune response and directly compete with pathogenic bacteria. Phytomedicine consists of the use of plant extracts as medicines or health-promoting agents, but in most cases the molecular mode of action of the active ingredients of these herbal extracts is unknown. Possible mechanisms include inhibition of H. pylori urease enzyme, disruption of bacterial cell membrane, and modulation of the host immune system. Other alternative therapies are also reviewed.

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A novel compound from celery seed with a bactericidal effect against <I>Helicobacter pylori</I>

Abstract: CAH may be suitable for further investigation as a potent agent for treating H. pylori infections.

Cited by 18 publications

References 54 publications

Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Traditional Medicine: Past, present and future research and development prospects and integration in the National Health System of Cameroon

Alternative therapies for Helicobacter pylori: probiotics and phytomedicine

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