A novel complex t(2;5;13)(p23;q35;q14) in small cell variant type anaplastic large cell lymphoma with peripheral involvement

Kong, Sun‐Young; Cho, Hyun Jung; Suk, Jung-Ho; Tak, Eunyoung; Ko, Young Hyeh; Kım, Kihyun; Kim, Sun‐Hee

doi:10.1016/j.cancergencyto.2004.03.004

Cited by 9 publications

(4 citation statements)

References 7 publications

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“… 9 , 18 So far a total of 26 cases of leukemic ALCL have been identified, mostly presenting with an elevated white blood cell count (average <100 × 10 9 /L). 6 , 8 , 9 , 10 , 12 , 13 , 14 , 17 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 Clinically, most patients presented with B-type symptoms, with fever being reported most (85.18%). The age of affected patients ranged from seven months to 63 years, but with 70% being younger than 30 years of age.…”

Section: Discussionmentioning

confidence: 99%

Small cell variant of anaplastic large cell lymphoma with leukemic presentation: a diagnostic challenge

Barrese

Sagramoso

Bacci

et al. 2017

Revista Brasileira de Hematologia e Hemoterapia

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Section: Discussionmentioning

confidence: 99%

Small cell variant of anaplastic large cell lymphoma with leukemic presentation: a diagnostic challenge

Barrese

Sagramoso

Bacci

et al. 2017

Revista Brasileira de Hematologia e Hemoterapia

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“…In our review of the literature we have identified only 20 cases of ALCL with a leukemic phase (Table 1). [5][6][7][8][9][10][11][12][13][14][15][16][17] Typically, patients present with an elevated WBC count <100 ¥ 10 9 /L.…”

mentioning

confidence: 99%

Anaplastic large cell lymphoma in leukemic phase: Extraordinarily high white blood cell count

Nguyen

Condron

Nguyen

et al. 2009

Pathology International

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Anaplastic large cell lymphoma (ALCL) is a distinct type of T/null-cell non-Hodgkin lymphoma that commonly involves nodal and extranodal sites. The World Health Organization of lymphoid neoplasms recognizes two types: anaplastic lymphoma kinase (ALK) positive or ALK negative, the former as a result of abnormalities involving the ALK gene at chromosome 2p23. Patients with ALCL rarely develop a leukemic phase of disease, either at the time of initial presentation or during the clinical course. Described herein is a patient with ALK+ ALCL, small cell variant, associated with the t(2;5)(p23;q35), who initially presented with leukemic involvement and an extraordinarily high leukocyte count of 529 x 10(9)/L, which subsequently peaked at 587 x 10(9)/L. Despite chemotherapy the patient died 2(1/2) months after diagnosis. In the literature review 20 well-documented cases are identified of ALCL in leukemic phase reported previously, with a WBC ranging from 15 to 151 x 10(9)/L. Leukemic phase of ALCL occurs almost exclusively in patients with ALK+ ALCL, most often associated with the small cell variant and the t(2;5)(p23;q35), similar to the present case. Patients with leukemic phase ALK+ ALCL appear to have a poorer prognosis than most patients with ALK+ ALCL.

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“…Although ALK-positive ALCL cases have a relatively good outcome, the small-cell leukemic variant is -irrespective of ALK-translocation status- an aggressive disease. A total of 35 cases of leukaemic, small cell variant of ALK-positive ALCLs have been previously reported [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ] ( Table 1 ) with limited follow-up time (from 1 to 63 months) in the surviving patients. All evidence points to an aggressive disease with a median overall survival of 12 months and a high tendency for central nervous system recurrences.…”

Section: Case Reportmentioning

confidence: 99%

Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman—Report of a Case with 9-Year Survival

Santonja,

Morillo-Giles,

Prieto-Pareja

et al. 2023

Medicina

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Anaplastic large cell lymphoma (ALCL) with leukaemic presentation (either ab initio or along the course of the disease) has been rarely reported. Irrespective of ALK expression in the neoplastic cells, it features a dismal prognosis. We report a rare case of leukaemic, small cell variant ALK-positive ALCL with 9-year survival in a young woman who was treated upfront with corticosteroids and standard chemotherapy, and review thoroughly the previously published cases. Such an unexpected, good outcome hints at the existence of different clinical subgroups in the leukaemic variant of ALK-positive ALCL.

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A novel complex t(2;5;13)(p23;q35;q14) in small cell variant type anaplastic large cell lymphoma with peripheral involvement

Cited by 9 publications

References 7 publications

Small cell variant of anaplastic large cell lymphoma with leukemic presentation: a diagnostic challenge

Small cell variant of anaplastic large cell lymphoma with leukemic presentation: a diagnostic challenge

Anaplastic large cell lymphoma in leukemic phase: Extraordinarily high white blood cell count

Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman—Report of a Case with 9-Year Survival

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