A Novel Combination of ω-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study

Abdolahi, Mina; Sarraf, Payam; Javanbakht, Mohammad Hassan; Honarvar, Niyaz Mohammadzadeh; Hatami, Mahsa; Soveyd, Neda; Tafakhori, Abbas; Sedighiyan, Mohsen; Djalali, Mona; Jafarieh, Arash; Masoudian, Yousef; Djalali, Mahmoud

doi:10.2174/1871527317666180625101643

Cited by 62 publications

(54 citation statements)

References 41 publications

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“…Eighty episodic migraine patients were randomized to receive a combination of ω-3 fatty acids (2500 mg) and nanocurcumin (80 mg) or ω-3 alone or nanocurcumin alone for two months. Notably, the combination of nanocurcumin and ω-3 downregulated IL-6 mRNA and decreased the serum levels of IL-6 as well as high sensitivity CRP (hs-CRP) [ 183 ].…”

Section: Clinical Trialsmentioning

confidence: 99%

Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives

et al. 2018

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Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which is commonly used as a spice in cooking and a yellow pigment in the food processing industry. Recent studies have demonstrated that curcumin has a variety of biological activities and pharmacological performances, providing protection and promotion of human health. In addition to presenting an overview of the gut metabolism of curcumin, this paper reviews the current research progress on its versatile bioactivity, such as antioxidant, anti-inflammatory, and immune-regulatory activities, and also intensively discusses its health benefits, including the protective or preventive effects on cancers and diabetes, as well as the liver, nervous system, and cardiovascular systems, highlighting the potential molecular mechanisms. Besides, the beneficial effects of curcumin on human are further stated based on clinical trials. Considering that there is still a debate on the beneficial effects of curcumin, we also discuss related challenges and prospects. Overall, curcumin is a promising ingredient of novel functional foods, with protective efficacy in preventing certain diseases. We hope this comprehensive and updated review will be helpful for promoting human-based studies to facilitate its use in human health and diseases in the future.

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Section: Clinical Trialsmentioning

confidence: 99%

Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives

et al. 2018

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“…The combination of fish oil and curcumin did not result in additional OA pain relief and seemed to dampen the reduction of OA pain and burden observed with fish oil alone. Combining fish oil with curcumin for additional benefits is a very new approach; clinical trials are limited, with inconsistent results [ 14 , 26–28 ], and effects on OA pain relief have not yet been tested. In migraine patients, fish oil and curcumin were found to have synergistic effects on reduction of inflammatory markers [ 26 , 27 ] and migraine attack frequency [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Combining fish oil with curcumin for additional benefits is a very new approach; clinical trials are limited, with inconsistent results [ 14 , 26–28 ], and effects on OA pain relief have not yet been tested. In migraine patients, fish oil and curcumin were found to have synergistic effects on reduction of inflammatory markers [ 26 , 27 ] and migraine attack frequency [ 27 ]. However, in people at high risk of developing type 2 diabetes, the combination did not result in any complementary effects on glycaemic control and blood lipids [ 28 ], and in our study we did not find any synergistic effects on cardiometabolic risk factors and cerebrovascular function [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity

Kuszewski

Wong

Howe

2020

Rheumatology Advances in Practice

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Objectives Osteoarthritis (OA) is a leading cause of chronic pain and disability. Next to inflammation, vascular pathology has been hypothesised to play a role in its etiology and progression. Due to side effects and low efficacy of pharmacological treatments, dietary supplements are popular as alternative treatments, but evidence of efficacy is limited. We tested whether fish oil and curcumin supplementation can reduce chronic pain and OA burden in older adults. Methods A 16-week randomized, double-blind, placebo-controlled, 2x2 factorial design supplementation trial with fish oil (2000mg docosahexaenoic acid + 400mg eicosapentaenoic acid/day), curcumin (160mg/day) or a combination of both was undertaken in sedentary overweight/obese older adults. Secondary outcomes included treatment changes in self-reported chronic pain and OA burden and whether changes are related to changes in small artery elasticity (surrogate marker for microvascular function), C-reactive protein (inflammatory marker) and well-being. Results The majority of participants (131/152) reported chronic pain, which was predominantly OA-specific. Fish oil significantly reduced OA-specific pain (P = 0.002, Cohen’s d = 0.56) and burden (P = 0.015, Cohen’s d = 0.45) compared to no fish oil treatment; reductions correlated with improvements in microvascular function and well-being. Curcumin, alone or in combination with fish oil, did not reduce pain measures. Conclusion Our findings indicate potential for fish oil to alleviate OA pain and burden in overweight/obese older adults. Further investigations should be undertaken in patients with clinically diagnosed OA to evaluate fish oil alone and as an adjunct to conventional pharmacotherapy and to investigate underlying mechanisms.

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“…A recent study confirms that both omega-3 FAs and nano-curcumin down-regulate IL-6 mRNA and, if used in combination, significantly decrease the serum concentration of both IL-6 and CRP, confirming the possible synergetic relation. [ 74 ]…”

Section: Discussionmentioning

confidence: 99%

Clinical use of omega-3 fatty acids in migraine

et al. 2020

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Background: Omega-3 fatty acids (FAs) can produce several beneficial effects and are commonly used for the treatment of migraine symptoms. Although current therapeutic measures for migraine included pharmacological therapies, dietary supplements, and herbal ingredients, dietary patterns, acupuncture, relaxation techniques, biofeedback, and psychotherapy, omega-3 FAs therapeutic role seems to be obtained through the inhibition or reduction of the release of inflammatory cytokines. The present review aims to provide updated information about the effects of omega-3 FAs in migraine treatment, investigating their clinical effects alone or in combination with other substances. Methods: Bibliographic research was conducted by examining scientific literature from January 2000 until January 31, 2020. Ten clinical studies were included in the review. Quality assessment of randomized controlled trials was performed by using the JADAD scale. Results: Clinical studies methodology is not always of good quality and results show moderate evidence concerning the therapeutic role of omega-3 FAs in migraine. Conclusion: Further clinical trials are necessary to implement the knowledge concerning the use of omega-3 fatty acids in the treatment of migraine.

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A Novel Combination of ω-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study

Abstract: It seems that ω-3 fatty acids and curcumin supplementation can be considered a new promising target in migraine prevention.

Cited by 62 publications

References 41 publications

Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives

Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives

Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity

Clinical use of omega-3 fatty acids in migraine

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