A novel chitosan- tussah silk fibroin/nano-hydroxyapatite composite bone scaffold platform with tunable mechanical strength in a wide range

Ran, Jiabing; Hu, Jingxiao; Sun, Guanglin; Chen, Si; Jiang, Pei; Shen, Xinyu; Tong, Hua

doi:10.1016/j.ijbiomac.2016.08.062

Cited by 35 publications

(18 citation statements)

References 62 publications

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“…6 C, this behavior was due to b-sheet structure. 42,43 In addition, BSF/TSF blend lms appeared two endothermic peaks at 278. 6 C and 360.6 C, which belonged to endothermic peaks of BSF and TSF, respectively.…”

Section: View Article Onlinementioning

confidence: 99%

A novel method to prepare tussah/Bombyx mori silk fibroin-based films

Yang

Wang

et al. 2018

RSC Adv.

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The possibility of using silk fibroin in biomaterials for tissue engineering is a subject of broad interest. In this study, Bombyx mori/tussah silk fibroin (BSF/TSF) blend films were prepared by solution casting using CaCl 2 / formic acid as a co-solvent and water as a rinse solvent. The morphology, crystallinity, thermal resistance, mechanical properties and water contact angle of the blend films as well as the biocompatibility were investigated. The BSF/TSF blend films displayed a smooth surface and specific nanostructure in their cross-section, originating from the nanofibril-preservation during fibroin dissolution. The water rinse process induced the formation of a stable b-sheet structure. The BSF film showed superior mechanical properties to the TSF film, and the blending with TSF led to a significant reduction in the strength and elasticity of blend films. However, adding the TSF component could regulate the hydrophilic properties and enhance cell growth on the blend films. The BSF/TSF blend films with specific nanostructure, stable secondary structure, appropriate mechanical properties, and good biocompatibility, are promising candidates for application in regenerative medicine.

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Section: View Article Onlinementioning

confidence: 99%

A novel method to prepare tussah/Bombyx mori silk fibroin-based films

Yang

Wang

et al. 2018

RSC Adv.

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“…Thus, by mixing different materials characterized by different properties, such as natural polymers with inorganic materials or synthetic polymers, numerous research groups have strived to design and fabricate periodontal materials for GTR/GBR with the requisite features and properties. [10][11][12] Dental plaque biofilm is considered as the initial symptom of a periodontal disease. 13 The key to successful treatment of a periodontal disease is the effective control of the dental plaque.…”

Section: Introductionmentioning

confidence: 99%

Preparation and biological characterization of the mixture of poly(lactic-co-glycolic acid)/chitosan/Ag nanoparticles for periodontal tissue engineering

Xue¹,

Hong

Gao³

et al. 2019

IJN

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ObjectiveThis study aims to produce nanoparticles of chitosan (CS), poly(lactic-co-glycolic acid) (PLGA), and silver and investigate the optimal composite ratio of these three materials for periodontal tissue regeneration.MethodsPLGA nanoparticles (nPLGA), CS nanoparticles (nCS), and silver nanoparticles (nAg) were prepared. The antibacterial properties of single nanoparticles and their effects on the proliferation and mineralization of periodontal membrane cells were investigated. Different ratios of nPLGA and nCS were combined, the proliferation and mineralization of periodontal membrane cells were investigated, and based on the results, the optimal ratio was determined. Finally, nPLGA and nCS in optimal ratio were combined with nAg, and the effects of the complex of these three materials on the proliferation and mineralization of periodontal membrane cells were investigated and tested in animals.ResultsThe single nanoparticles were found to have no cytotoxicity and were able to promote cell mineralization. nCS and nAg in low concentrations showed antibacterial activity; however, nAg inhibited cell proliferation. The nPLGA and nCS complex in 3:7 ratio contributed to cell mineralization and had no cytotoxicity. nPLGA/nCS/nAg complex, which had the optimal proportion of the three materials, showed no cytotoxicity and contributed to cell mineralization.ConclusionnPLGA/nCS/nAg complex had no cytotoxicity and contributed to cell mineralization. The 3:7 ratio of nPLGA/nCS and 50 µg/mL nAg were found as the optimal proportion of the three materials.

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“…Results are represented in Figure . Hap nanoparticles exhibit several typical crystal peaks at 2θ = 26 and 32°, similar to the literature, and the crystal phase of Hap in the hydrogels matched well with Joint Committee on Powder Diffraction Standards (JCPDS) references of Hap (JCPDS file no. 00‐024‐0033).…”

Section: Resultsmentioning

confidence: 99%

Photocrosslinked methacrylated poly(vinyl alcohol)/hydroxyapatite nanocomposite hydrogels with enhanced mechanical strength and cell adhesion

Zhou

Dong

Liang

et al. 2018

J. Polym. Sci. Part A: Polym. Chem.

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Poly(vinyl alcohol) (PVA) hydrogels with high water content, good load‐bearing property, low frictional behavior as well as excellent biocompatibility have been considered as promising cartilage replacement materials. However, the lack of sufficient mechanical properties and cell adhesion are two critical barriers for their application as cartilage substitutes. To address these problems, herein, methacrylated PVA with low degree of substitution of methacryloyl group has been synthesized first. Then, methacrylated PVA‐glycidyl methacrylate/hydroxyapatite (PVA‐GMA/Hap) nanocomposite hydrogels have been developed by the photopolymerization approach subsequently. Markedly, both pure PVA‐GMA hydrogel and PVA‐GMA/Hap nanocomposite hydrogels exhibit excellent performance in compressive tests, and they are undamaged during compressive stress–strain tests. Moreover, compared to pure PVA‐GMA hydrogels, 8.5‐fold, 7.4‐fold, and 14.2‐fold increase in fracture stress, Young's modulus and toughness, respectively, can be obtained for PVA‐GMA/Hap nanocomposite hydrogels with 10 wt % Hap nanoparticles. These enhancements can be ascribed to the intrinsic property of PVA‐GMA and strong hydrogen bonding interactions between PVA‐GMA chain and Hap nanoparticles. More interestingly, significant improvement in the cell adhesion can also be successfully achieved by incorporation of Hap nanoparticles. These biocompatible nanocomposite hydrogels have great potential to be used as cartilage substitutes. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 1882–1889

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A novel chitosan- tussah silk fibroin/nano-hydroxyapatite composite bone scaffold platform with tunable mechanical strength in a wide range

Cited by 35 publications

References 62 publications

A novel method to prepare tussah/Bombyx mori silk fibroin-based films

A novel method to prepare tussah/Bombyx mori silk fibroin-based films

Preparation and biological characterization of the mixture of poly(lactic-co-glycolic acid)/chitosan/Ag nanoparticles for periodontal tissue engineering

Photocrosslinked methacrylated poly(vinyl alcohol)/hydroxyapatite nanocomposite hydrogels with enhanced mechanical strength and cell adhesion

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