A novel CD4‐conjugated ultraviolet light‐activated photocatalyst inactivates HIV‐1 and SIV efficiently

Yamaguchi, Koushi; Sugiyama, Takahiro; Katō, Susumu; Kondo, Yoichi; Ageyama, Naohide; Kanekiyo, Masaru; Iwata, Misao; Koyanagi, Yoshio; Yamamoto, Naoki; Honda, Mitsuo

doi:10.1002/jmv.21235

Cited by 14 publications

(9 citation statements)

References 32 publications

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“…Therefore, TiO 2 nanoparticles can function as the inorganic photosensitizers to produce large amounts of reactive oxygen species (ROS) for photodynamic therapy (PDT) . Especially, the semiconductor nature and unique photoresponsiveness of TiO 2 have been employed for the degradation of organic substrates and deactivation of microorganisms/viruses …”

Section: Introductionmentioning

confidence: 99%

Exogenous Physical Irradiation on Titania Semiconductors: Materials Chemistry and Tumor‐Specific Nanomedicine

2018

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Titania semiconductors can be activated by external physical triggers to produce electrons (e−) and holes (h+) pairs from the energy‐band structure and subsequently induce the generation of reactive oxygen species for killing cancer cells, but the traditional ultraviolet light with potential phototoxicity and low‐tissue‐penetrating depth as the irradiation source significantly hinders the further in vivo broad biomedical applications. Here, the very‐recent development of novel exogenous physical irradiation of titania semiconductors for tumor‐specific therapies based on their unique physiochemical properties, including near infrared (NIR)‐triggered photothermal hyperthermia and photodynamic therapy, X‐ray/Cerenkov radiation‐activated deep‐seated photodynamic therapy, ultrasound‐triggered sonodynamic therapy, and the intriguing synergistic therapeutic paradigms by combined exogenous physical irradiations are in focus. Most of these promising therapeutic modalities are based on the semiconductor nature of titania nanoplatforms, together with their defect modulation for photothermal hyperthermia. The biocompatibility and biosafety of these titania semiconductors are also highlighted for guaranteeing their further clinical translation. Challenges and future developments of titania‐based therapeutic nanoplatforms and the corresponding developed therapeutic modalities for potential clinical translation of tumor‐specific therapy are also discussed and outlooked.

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Section: Introductionmentioning

confidence: 99%

Exogenous Physical Irradiation on Titania Semiconductors: Materials Chemistry and Tumor‐Specific Nanomedicine

2018

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“…Photoactivation of titanium dioxide by UV generates reactive oxygen molecules on the surface of TiO 2 and has been shown to effectively inactivate influenza A virus [ 39 ], HIV-1 [ 40 ], and murine norovirus [ 40 , 41 ]. Halogen and interhalogen TiO 2 nanoparticles, except for chlorinated adduct, completely inactivated bacteriophages MS-2, ψ-X174 and PRD-1, showing that oxidizing potential can be generated without UV photoactivation [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

Protective hybrid coating containing silver, copper and zinc cations effective against human immunodeficiency virus and other enveloped viruses

Hodek

Zajícová

Lovětinská-Šlamborová

et al. 2016

BMC Microbiol

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BackgroundHealthcare-acquired infections by pathogenic microorganisms including viruses represent significant health concern worldwide. Next to direct transmission from person-to-person also indirect transmission from contaminated surfaces is well documented and important route of infections. Here, we tested antiviral properties of hybrid coating containing silver, copper and zinc cations that was previously shown to be effective against pathogenic bacteria including methicillin-resistant Staphylococcus aureus. Hybrid coatings containing silver, copper and zinc cations were prepared through radical polymerization via sol-gel method and applied on glass slides or into the wells of polymethylmethacrylate plates. A 10 μl droplet of several viruses such as human immunodeficiency virus type 1 (HIV-1), influenza, dengue virus, herpes simplex virus, and coxsackievirus was added to coated and uncoated slides or plates, incubated usually from 5 to 240 min and followed by titer determination of recovered virus.ResultsScanning electron microscopy analysis showed better adhesion of coatings on glass surfaces, which resulted in 99.5–100 % HIV-1 titer reduction (3.1 ± 0.8 log10TCID50, n = 3) already after 20 min of exposure to coatings, than on coated polymethylmethacrylate plates with 75–100 % (1.7 ± 1.1 log10TCID50, n = 3) and 98–100 % (2.3 ± 0.5 log10TCID50, n = 3) HIV-1 titer reduction after 20 and 120 min of exposure, respectively. Slower virucidal kinetics was observed with other enveloped viruses, where 240 min exposure to coated slides lead to 97 % (dengue), 100 % (herpes simplex) and 77 % (influenza) reduction in virus titers. Interestingly, only marginal reduction in viral titer after 240 min of exposure was noticed for non-enveloped coxsackie B3 virus.ConclusionsOur hybrid coatings showed virucidal activity against HIV and other enveloped viruses thus providing further findings towards development of broad-spectrum antimicrobial coating suitable for surfaces in healthcare settings.

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“…4 Semiconductor TiO 2 is well known as a photocatalyst in the degradation of organic substrates 5 and the deactivation of microorganisms [6][7][8][9][10][11] and viruses. 12 Under ultraviolet light (UV) excitation, TiO 2 nanoparticles of various sizes and morphologies have been reported to exhibit cytotoxicity toward some tumors. [13][14][15][16][17][18][19][20][21][22] Although nanomaterials tend to passively accumulate in tumors due to the so-called enhanced "permeability and retention effect" and often serve as "nanocarriers" for chemotherapeutics, this passive strategy has limitations because of its random delivery mode.…”

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confidence: 99%

A High-Performance Nanobio Photocatalyst for Targeted Brain Cancer Therapy

et al. 2009

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We report pronounced and specific anti-glioblastoma cell phototoxicity of 5 nm TiO2 particles covalently tethered to an antibody via dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate cancer cell programmed cell death. Synchrotron X-Ray Fluorescence Microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the sub-micrometer scale.

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A novel CD4‐conjugated ultraviolet light‐activated photocatalyst inactivates HIV‐1 and SIV efficiently

Cited by 14 publications

References 32 publications

Exogenous Physical Irradiation on Titania Semiconductors: Materials Chemistry and Tumor‐Specific Nanomedicine

Exogenous Physical Irradiation on Titania Semiconductors: Materials Chemistry and Tumor‐Specific Nanomedicine

Protective hybrid coating containing silver, copper and zinc cations effective against human immunodeficiency virus and other enveloped viruses

A High-Performance Nanobio Photocatalyst for Targeted Brain Cancer Therapy

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