A Novel Capsule-Delivered Enteric Drug-Injection Device for Delivery of Systemic Biologics: A Pilot Study in a Porcine Model

Sarker, Sunandita; Wankum, Benjamin; Perey, Trevor; Mau, Musharrat Mustaree; Shimizu, Jeff; Jones, Ryan; Terry, Benjamin S.

doi:10.1109/tbme.2021.3129653

Cited by 7 publications

(3 citation statements)

References 51 publications

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“…Except trigging by springs, Sarker et al [ 162 ] reported a swallowable capsule for intestinal drug delivery (SCIDD). It can attach the capsule to the gastrointestinal tract via a tissue attachment mechanism (TAM) and then the suction generate by the negative pressure chamber inside the SCIDD will complete the insertion of drug-loaded microneedle into the gastrointestinal mucosa.…”

Section: Oral Administration Microrobotsmentioning

confidence: 99%

Oral administration microrobots for drug delivery

Ren,

Hu,

Qin

et al. 2024

Bioactive Materials

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Section: Oral Administration Microrobotsmentioning

confidence: 99%

Oral administration microrobots for drug delivery

Ren,

Hu,

Qin

et al. 2024

Bioactive Materials

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“…However, the intensity of external magnetic field (|Ba|> 90 mT) is large. A drugdelivery-ingestible capsule robot with tissue attachment mechanism is shown in figure 6(b), which takes direct injection through insensate layers of small intestine [61,62]. Fractional factorial approach was used to optimize the attachment success rate.…”

Section: Medical Operation Of Capsule Robotsmentioning

confidence: 99%

Functional capsule robots: a review of locomotion, pose, medical operation and wireless power transmission reported in 2018–2023

Hua,

Deng,

Gołdasz

et al. 2024

Smart Mater. Struct.

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As a new type of medical equipment, capsule robots are actuated wirelessly by space magnetic field, which have important application advantages in the diagnosis and treatment of gastrointestinal diseases. Active locomotion is the basis of medical operation for capsule robots, as well as an important guarantee to avoid misdetection and retention in the body. Furthermore, the pose estimation of the capsule robots in the gastrointestinal tract can provide accurate information for medical operation and improve work efficiency. Specific medical operation is one of the ultimate goals of capsule robots, and it is the key to realize the non-invasive diagnosis and treatment technology. Moreover, replacing traditional chemical batteries with wireless power transfer technology not only reduces the dimensions of the capsule robots, but also provides unlimited possibilities for the development of medical operations. In this work, the state-of-the-art capsule robots are reviewed according to the research directions of the locomotion, pose, medical operation and wireless power transmission reported from 2018 to 2023. In light of the four main directions of the capsule robots, some important research achievements and approaches are summarized. In particular, some outstanding advances on innovative structure, efficient methodology and appropriate application of the capsule robots are introduced in details. Finally, an overview of the significant issues occurred in the capsule robots is reported, and the developing trends are discussed.

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“…Ingestible capsules of varied size and function, employed in vivo for testing in porcine studies, are summarized in Table S2 (Supporting Information). [25,[63][64][65][66][67][68][69][70][71][72][73] The main limiting factors for further scaling the H 2 S sensing capsule are the size of the COTS electronic components and compatibility of the battery chemistry. Bluetooth LE has an instantaneous current consumption of ≈10 mA (at +0 dB antenna gain), which prevents the use of alternative safe battery chemistries, such as silver oxide (Ø = 9.5 mm), without greatly reducing the wireless transmission rate (10 s).…”

Section: Ingestible Gas-sensing Capsule Designmentioning

confidence: 99%

Miniaturized Capsule System Toward Real‐Time Electrochemical Detection of H₂S in the Gastrointestinal Tract

Stine,

Ruland,

Beardslee

et al. 2023

Adv Healthcare Materials

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Hydrogen sulfide (H2S) is a gaseous inflammatory mediator and important signaling molecule for maintaining gastrointestinal (GI) homeostasis. Excess intraluminal H2S in the GI tract has been implicated in inflammatory bowel disease and neurodegenerative disorders; however, the role of H2S in disease pathogenesis and progression is unclear. Herein, an electrochemical gas‐sensing ingestible capsule is developed to enable real‐time, wireless amperometric measurement of H2S in GI conditions. A gold (Au) three‐electrode sensor is modified with a Nafion solid‐polymer electrolyte (Nafion‐Au) to enhance selectivity toward H2S in humid environments. The Nafion‐Au sensor‐integrated capsule shows a linear current response in H2S concentration ranging from 0.21 to 4.5 ppm (R2 = 0.954) with a normalized sensitivity of 12.4% ppm−1 when evaluated in a benchtop setting. The sensor proves highly selective toward H2S in the presence of known interferent gases, such as hydrogen (H2), with a selectivity ratio of H2S:H2 = 1340, as well as toward methane (CH4) and carbon dioxide (CO2). The packaged capsule demonstrates reliable wireless communication through abdominal tissue analogues, comparable to GI dielectric properties. Also, an assessment of sensor drift and threshold‐based notification is investigated, showing potential for in vivo application. Thus, the developed H2S capsule platform provides an analytical tool to uncover the complex biology‐modulating effects of intraluminal H2S.

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A Novel Capsule-Delivered Enteric Drug-Injection Device for Delivery of Systemic Biologics: A Pilot Study in a Porcine Model

Cited by 7 publications

References 51 publications

Oral administration microrobots for drug delivery

Oral administration microrobots for drug delivery

Functional capsule robots: a review of locomotion, pose, medical operation and wireless power transmission reported in 2018–2023

Miniaturized Capsule System Toward Real‐Time Electrochemical Detection of H₂S in the Gastrointestinal Tract

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A Novel Capsule-Delivered Enteric Drug-Injection Device for Delivery of Systemic Biologics: A Pilot Study in a Porcine Model

Cited by 7 publications

References 51 publications

Oral administration microrobots for drug delivery

Oral administration microrobots for drug delivery

Functional capsule robots: a review of locomotion, pose, medical operation and wireless power transmission reported in 2018–2023

Miniaturized Capsule System Toward Real‐Time Electrochemical Detection of H2S in the Gastrointestinal Tract

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Product

Resources

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Miniaturized Capsule System Toward Real‐Time Electrochemical Detection of H₂S in the Gastrointestinal Tract