A novel biomarker for predicting sepsis mortality

Abstract

The mortality rate of patients diagnosed with sepsis is high. To date, many markers in sepsis patients have been studied to diagnose, determine their prognosis, and contribute to treatment. These studies were conducted in both experimental and clinical settings, but clinical trials remain limited. Therefore, more well-planned clinical studies are needed in patients with sepsis. The current study aimed to examine the prognostic role of signal peptide-CUB-epidermal growth factor-like domain-containing protein 1 (SCUBE-1) in sepsis and sepsis-related mortality. We also wanted to study its relationship with inflammatory markers and scoring systems. This prospective, cross-sectional, observational study included a total of 187 sepsis cases treated in the intensive care unit. Venous samples were obtained after diagnosis. The patients were separated into 2 groups: (1) the survivor group who were discharged or transferred within 28 days of the first diagnosis and (2) the nonsurvivor group who died within 28 days of the first diagnosis. The SCUBE-1, C-reactive protein, procalcitonin, creatinine, lactate values, acute physiology and chronic health evaluation 2, sequential organ failure assessment scores were significantly higher in the survivor group, and platelets were higher in the survivor group. In addition, SCUBE-1 positively correlated with the inflammatory markers C-reactive protein, lactate, sequential organ failure assessment, and acute physiology and chronic health evaluation 2. Additionally, the SCUBE-1 value predicts 28-day mortality, and the optimal cutoff value for predicting mortality is 4,73 pg/mL. Sepsis is a disease with high mortality. SCUBE-1 can be used as a new prognostic factor for sepsis patients.

Discovering the Protective Effects of Resveratrol on Aflatoxin B1-Induced Toxicity: A Whole Transcriptomic Study in a Bovine Hepatocyte Cell Line

“…The sole gene downregulated by R, SCUBE1, a cell surface glycoprotein found in platelet and endothelial cells [87], was particularly interesting. A very recent study [88] has demonstrated that SCUBE1 is an independent prognostic factor in septic patients, and positive correlates with accepted inflammatory biomarkers and "Acute Physiology And Chronic Health Evaluation II" (APACHE-2), a severity-of-disease classification system [89]. Moreover, accumulation of this protein in blood is associated with vascular dysfunctions like atherosclerotic lesions or ischemic stroke [90], and ovarian impairment [91,92].…”

Serum Lactate-Albumin Ratio: Soothsayer for Outcome in Sepsis

“…The Sequential Organ Failure Assessment (SOFA) score was used for predicting deaths in patients with sepsis in the ICU. A score of two or more was considered a predictor of mortality in sepsis patients [11][12][13].…”

Prognostic value of the lactate/albumin ratio for predicting mortality in patients with pneumosepsis in intensive care units

“…The Sequential Organ Failure Assessment (SOFA) scoring system has been used to diagnose patients with sepsis in the ICU and determine their prognosis. [ 5 – 7 ]…”

“…The Acute Physiology and Chronic Health Evaluation 2 (APACHE-2) scoring system is frequently used in several hospitals. The Sequential Organ Failure Assessment (SOFA) scoring system has been used to diagnose patients with sepsis in the ICU and determine their prognosis [5–7] …”

“…The Sequential Organ Failure Assessment (SOFA) scoring system has been used to diagnose patients with sepsis in the ICU and determine their prognosis. [5][6][7] Lactic acidosis often occurs in sepsis when lactate production exceeds lactate consumption. The major associations of lactic acidosis are divided into disorders associated with tissue hypoxia (type A) and disorders in which tissue hypoxia is absent (type B).…”