A novel bio-inspired bone-mimic self-healing cement paste based on hydroxyapatite formation

Li, Qiu; Liu, Zhilin; Chen, Wanyu; Yuan, Bo; Liu, Xiang; Chen, Wei

doi:10.1016/j.cemconcomp.2019.103357

Cited by 25 publications

(6 citation statements)

References 44 publications

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“…Defect stabilization and healing itself is typically based on the formation of salts in the crack, blocking of cracks with impurities or particles resulting from water infiltration or crack spalling, further hydration of unreacted cement or finally the expansion of cementitious matrix in the crack flanks 15 . Self-healing with apatite materials was shown for apatite coatings and by utilizing phosphate-containing hydrogel in Portland cement paste 20,21 .…”

Section: Self-healing Capacity Of Fiberreinforced Calcium Phosphate Cmentioning

confidence: 99%

Self-healing capacity of fiber-reinforced calcium phosphate cements

Boehm

Meininger

Gbureck

et al. 2020

Sci Rep

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A major problem concerning the mechanical properties of calcium phosphate cements (CPC) is related to their inherent brittleness, which limits their applicability to non-load bearing bone defects. In this work the preparation of a damage tolerant CPC is presented, where the incorporation of functionalized carbon fibers facilitates steady state flat crack propagation with crack openings below 10 µm. A subsequent self-healing process in simulated body fluid, that mimics the in vivo mineralization of bioactive surfaces, closes the cracks and completely restores the mechanical properties. Hereby, two pathways of self-healing are presented: i) intrinsic healing that bases on the inherent bioactive properties of the cement matrix and chemically treated fibers, and ii) capsule based extrinsic healing, where H2PO4- is released as an initiator for the apatite formation. Such damage tolerant CPCs with self-healing capacity are of particular interest to increase the lifetime of implants as well as in the field of load-bearing bioceramics.

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Section: Self-healing Capacity Of Fiberreinforced Calcium Phosphate Cmentioning

confidence: 99%

Self-healing capacity of fiber-reinforced calcium phosphate cements

Boehm

Meininger

Gbureck

et al. 2020

Sci Rep

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“…PEG-based hydrogels exhibit extraordinary osteogenic induction ability when mixed with bone-promoting materials ( Liu W. et al, 2021 ). As an inorganic component of normal bone tissue, hydroxyapatite (HA) has outstanding compatibility and bone conductivity ( Li et al, 2019 ). Adding HA directly into a PEG-based hydrogel endows the composite hydrogel with osteogenic function.…”

Section: Fabrication Strategy Of Peg-based Hydrogelsmentioning

confidence: 99%

Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

Sun

Cui

Yuan

et al. 2023

Front. Bioeng. Biotechnol.

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Drug delivery systems composed of osteogenic substances and biological materials are of great significance in enhancing bone regeneration, and appropriate biological carriers are the cornerstone for their construction. Polyethylene glycol (PEG) is favored in bone tissue engineering due to its good biocompatibility and hydrophilicity. When combined with other substances, the physicochemical properties of PEG-based hydrogels fully meet the requirements of drug delivery carriers. Therefore, this paper reviews the application of PEG-based hydrogels in the treatment of bone defects. The advantages and disadvantages of PEG as a carrier are analyzed, and various modification methods of PEG hydrogels are summarized. On this basis, the application of PEG-based hydrogel drug delivery systems in promoting bone regeneration in recent years is summarized. Finally, the shortcomings and future developments of PEG-based hydrogel drug delivery systems are discussed. This review provides a theoretical basis and fabrication strategy for the application of PEG-based composite drug delivery systems in local bone defects.

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“…The self-healing characteristic of a material refers to its ability to restore its physical and mechanical properties through inherent self-healing capacity, thereby extending its service life with minimal maintenance costs. Many scholars have studied the selfhealing properties of new composite materials [12], such as form-stable phase change materials (FSPCMs) [13], ultra-low-temperature self-healing polyurethane material [14], and self-healing cementitious material [15]. Zhang et al designed and prepared three types of self-healing granules, evaluated the self-healing efficiency under different conditions and elucidated the self-healing mechanism [16].…”

Section: Introductionmentioning

confidence: 99%

Research on self-healing characteristic and state prediction method of the copper based powder metallurgy materials on friction interface

Wu,

Yang,

Shu

et al. 2024

Surf. Topogr.: Metrol. Prop.

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In high power density transmission systems, the friction and wear characteristic of copper based powder metallurgy materials is directly linked to working reliability. Moreover, these materials have frictional self-healing characteristic at the material interface. This paper focuses on exploring the healing mechanism of copper based powder metallurgy materials and conducts "damage-healing" tests, proposing a method to characterize the self-healing characteristic. Subsequently, through comparative tests, the influence of temperature, speed, and pressure on the self-healing characteristics is analyzed. The results show that the increase in temperature reduces the furrow width and depth by 15.30% and 59.76%, respectively. Pressure has the greatest effect on surface roughness, reducing it by 67%. Meanwhile, this paper developed a PSO (Particle Swarm Optimization)-LSTM (Long Short-Term Memory) method to accurately predict the self-healing characterization parameters and self-healing time with small error (average 4.35 %) and high correlation coefficient (R2) (average 0.976). This study contributes to the development of interface repair technology for friction materials.

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A novel bio-inspired bone-mimic self-healing cement paste based on hydroxyapatite formation

Cited by 25 publications

References 44 publications

Self-healing capacity of fiber-reinforced calcium phosphate cements

Self-healing capacity of fiber-reinforced calcium phosphate cements

Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

Research on self-healing characteristic and state prediction method of the copper based powder metallurgy materials on friction interface

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