A novel autoantibody reactive with carbonic anhydrase in sera from patients with systemic lupus erythematosus and Sjögren's syndrome

Inagaki, Yasunori; Jinno-Yoshida, Yoko; Hamasaki, Youichiro; Ueki, Hiroaki

doi:10.1016/0923-1811(91)90060-b

Cited by 92 publications

(56 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A high frequency of the presence of an autoantibody to CAII has been reported in systemic lupus erythematosus and Sjögren syndrome [37], and the development of sialoadenitis, a characteristic of Sjögren syndrome, has been reported in mice that have been immunized with CAII [38]. However, it is unlikely that the anti-CAII antibody plays a role in the destruction of erythrocytes, as seen in autoimmune haemolytic anaemia, because CAII is a cytosolic protein.…”

Section: Discussionmentioning

confidence: 99%

Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production

Iuchi

Okada

Onuma

et al. 2007

Biochemical Journal

149

105

View full text Add to dashboard Cite

Reactive oxygen species are involved in the aging process and diseases. Despite the important role of Cu/Zn SOD (superoxide dismutase) encoded by SOD1, SOD1 −/− mice appear to grow normally under conventional breeding conditions. In the present paper we report on a novel finding showing a distinct connection between oxidative stress in erythrocytes and the production of autoantibodies against erythrocytes in SOD1 −/− mice. Evidence is presented to show that SOD1 is primarily required for maintaining erythrocyte lifespan by suppressing oxidative stress. A SOD1 deficiency led to an increased erythrocyte vulnerability by the oxidative modification of proteins and lipids, resulting in anaemia and compensatory activation of erythropoiesis. The continuous destruction of oxidized erythrocytes appears to induce the formation of autoantibodies against certain erythrocyte components, e.g. carbonic anhydrase II, and the immune complex is deposited in the glomeruli. The administration of an antioxidant, N-acetylcysteine, suppressed erythrocyte oxidation, ameliorated the anaemia, and inhibited the production of autoantibodies. These data imply that a high level of oxidative stress in erythrocytes increases the production of autoantibodies, possibly leading to an autoimmune response, and that the intake of antioxidants would prevent certain autoimmune responses by maintaining an appropriate redox balance in erythrocytes.

show abstract

Section: Discussionmentioning

confidence: 99%

Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production

Iuchi

Okada

Onuma

et al. 2007

Biochemical Journal

149

105

View full text Add to dashboard Cite

show abstract

“…1b. have reported that antibodies against CA II and CA I exist in sera of patients with autoimmune disease with endocrine organ originated [13,14,[19][20][21]. As it is known, PCOS is also an endocrine organ originated disease, and it is highly suspected to be involved in autoimmune based pathogenesis.…”

mentioning

confidence: 99%

“…It has been suggested that autoimmune mechanisms may be involved, and antibodies against different candidate auto antigens, including carbonic anhydrases as a group of metalloenzymes widely distributed in human tissues, have been demonstrated in subjects with some autoimmune diseases [8]. Although previously CA II autoantibodies have been observed in various autoimmune and idiopathic diseases, such as Systemic Lupus Erythematosus (SLE) (28.5%), Graves' disease (25%), Sjögren syndrome (SjS) (62%), and primary biliary cirrhosis (25%), rheumatoid arthritis (27.8%), endometriosis (69.6%) [8,[19][20][21], according to our findings there were no significant differences in anti-CA II antibody frequencies between PCOS patients and controls (p>0.05).…”

mentioning

confidence: 99%

Serum anti-carbonic anhydrase I and II antibodies and polycystic ovary syndrome

Menteşe¹,

Güven²,

Sümer³

et al. 2013

Turk J Bioch

View full text Add to dashboard Cite

“…De todos modos, estos autoanticuerpos, que pueden ir dirigidos contra tejido mamario, bronquial, glándulas salivares y gástrica, páncreas y túbulo renal, no son específicos de P.A. Así, ACA-II puede ser detectado en algunos pacientes con Síndrome de Sjögren o lupus eritematoso sistémico (17), y ALF en colitis ulcerosa y colangitis esclerosante primaria (18). Otros Auto-Ac están en estudio, como el anti-PTSI (Pancreatic Secretory Trypsin nhibitor), que también puede estar relacionado con la patogénesis de la enfermedad y que podría servir como nuevo marcador diagnóstico (19).…”

Section: Fig 2 Masa En Cabeza De Páncreas Con Resolución Radiológicunclassified

Pancreatitis autoinmune: A propósito de un caso

Sanchez

Morente

Pedro

et al. 2008

An. Med. Interna (Madrid)

View full text Add to dashboard Cite

INTRODUCCIÓNLa pancreatitis autoinmune (PA), es un término descrito por primera vez en 1995 por Yoshida y cols. (1) También ha sido denominada en la literatura médica como pancreatitis linfoplasmocitaria esclerosante, pseudotumor pancreático, pancreatitis primaria inflamatoria o pancreatitis crónica no alcohólica con destrucción ductal (2).Es una entidad muy infrecuente, con aproximadamente 100 casos descritos en Literatura. La PA constituye cerca del 5% de los casos de pancreatitis crónica (3). Así mismo el 5% de los casos de cirugía pancreática corresponde a patología benigna, entre los que se encuentra esta entidad (4).El interés por esta patología en los últimos años se ha incrementado por las mayores posibilidades diagnósticas debido al uso de nuevos marcadores de la enfermedad y nuevas técnicas de biopsia pancreática (5,6).Presentamos un nuevo caso de P.A, para mostrar la importancia de la sospecha diagnóstica precoz debido a la excelente respuesta al tratamiento adecuado. CASO APORTADOMujer de 33 años de edad, sin antecedentes previos de interés. Presentó cuadro de 3 semanas de evolución de prurito intenso, astenia, anorexia y pérdida de peso, al cual se asocia ictericia, coluria y acolia en los últimos días. En la exploración física destaca ictericia de piel y mucosas, siendo el resto de las exploración física normal.En la analítica presentaba Hb 11,2 mg/d, plaquetas 286.000 x 103/µl, leucocitos 9.460 x 103/µl (fórmula normal). Actividad de protrombina 105%. Glucosa 89 mg/dl; Urea 45 mg/dl; Creatinina 1,2 mg/dl; Bilirrubina total total 12,4 mg/dl; Bilirrubina directa 9,7 mg/dl; GOT 53 U/l; GPT 60 U/l; GGT 66 U/l; FA 388 U/l; Amilasa 186 U/l; LDH 292 U/l; VSG 54 mm; PCR 35 mg/l. Serología virus [0212-7199 (2008) RESUMENLa pancreatitis autoinmune es una reciente entidad a tener en cuenta en el diagnóstico diferencial de pancreatits crónica-masa pancreática. La presencia de estenosis difusa e irregular del Wirsung, junto con niveles elevados de IgG4, presencia de determinados autoanticuerpos e infiltración linfoplasmocitaria de páncreas son la clave del diagnóstico.La sospecha diagnóstica precoz y la colaboración multidisciplinar es vital en estos casos, ya que puede evitar cirugía innecesaria, puesto que el diagnóstico diferencial se establece con entidades entre las que se encuentra cáncer de páncreas, pancreatitis crónica, cirrosis biliar primaria o colangitis esclerosante primaria.Además, la pancreatitis autoinmune tiene excelente respuesta a tratamiento esteroideo, con resolución completa de parámetros clínicos, analíticos y radiológicos, como ocurría en nuestro paciente. Debido al escaso número de casos descritos en la Literatura, sería necesario la elaboración de estudios con seguimiento largo plazo para conocer pronóstico y frecuencia de asociación a otras patologías.

show abstract

A novel autoantibody reactive with carbonic anhydrase in sera from patients with systemic lupus erythematosus and Sjögren's syndrome

Cited by 92 publications

References 16 publications

Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production

Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production

Serum anti-carbonic anhydrase I and II antibodies and polycystic ovary syndrome

Pancreatitis autoinmune: A propósito de un caso

Contact Info

Product

Resources

About