A novel asymmetric membrane osmotic pump capsule with in situ formed delivery orifices for controlled release of gliclazide solid dispersion system

Yang, Yue; Zhao, Zhinan; Wang, Yongfei; Yang, Lu; Liu, Dandan; Yang, Xinggang; Pan, Weisan

doi:10.1016/j.ijpharm.2016.04.061

Cited by 22 publications

(3 citation statements)

References 63 publications

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“…The results were in close agreement with previously published research. 18 In the PM GLC , peaks of pure GLC at various 2θ angle were observed but with reduced intensity, which indicated that the crystallinity of GLC was maintained in the physical mixture. Reduction of peak intensity might attribute to the slight amorphous nature of GLC generated during physical mixing of GLC and Soluplus® to prepare sample for XRD.…”

Section: Crystallinity Analysis (Pxrd)mentioning

confidence: 97%

Formulation of Dispersed Gliclazide Powder in Polyethylene Glycol–Polyvinyl Caprolactam– Polyvinyl Acetate Grafted Copolymer Carrier for Capsulation and Improved Dissolution

Dukhan¹,

Amalina²,

Oo³

et al. 2018

IJPER

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Background: Oral bioavailability of gliclazide, a hypoglycemic drug, is hindered by its low aqueous solubility. Improvement of solubility will enhance dissolution rate and in turn the bioavailability. This research aimed to formulate the solid dispersed gliclazide using a novel polyethylene glycol-polyvinyl caprolactam-polyvinyl acetate grafted copolymer (Soluplus®) as carrier to enhance in-vitro dissolution and to study drug-carrier physical interaction. Method: Final solid dispersion (SDGLC) containing drug:carrier (1:8 w/w) was prepared by solvent evaporation after drug-polymer miscibility study. The SDGLC powder was characterized by differential scanning calorimetry (DSC), attenuated total reflectance infra-red spectroscopy (ATR-IR), powder X-ray diffraction (PXRD), and scanning electron microscopy (SEM). SDGLC powder was filled in gelatin capsule after flowability and moisture analysis followed by assay, disintegration and in-vitro dissolution study. Results: Miscibility study showed negative values of free energy transfer indicating spontaneous solubilization of drug with increase in carrier concentration. Absence of sharp melting peak in SDGLC was observed by DSC. Reduced peak intensity at specific 2θ values in PXRD indicates loss of crystallinity in solid dispersion. Interaction to form H-bond between gliclazide and Soluplus® was evidenced by ATR-IR. SDGLC filled capsule resulted in 20% improved dissolution (approximately 20% higher) in 0.1(N) HCl and phosphate buffer pH 7.4 compared to physical mixture (gliclazide-Soluplus®) containing capsule. Conclusion: Soluplus® effectively enhanced gliclazide solubility in solid dispersed state and SDGLC powder filled capsules could provide pH independent and improved in-vitro dissolution for gliclazide.

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Section: Crystallinity Analysis (Pxrd)mentioning

confidence: 97%

Formulation of Dispersed Gliclazide Powder in Polyethylene Glycol–Polyvinyl Caprolactam– Polyvinyl Acetate Grafted Copolymer Carrier for Capsulation and Improved Dissolution

Dukhan¹,

Amalina²,

Oo³

et al. 2018

IJPER

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“…Therefore, as long as the drug solution remains saturated, constant drug release can be sustained, and the release rate is mostly influenced by the drug solubility. Many works have demonstrated the feasibility of single-compartment osmotic micropumps as drug delivery vehicles, including delivery of a single kind of drug molecule or even synchronous delivery of different kinds of drugs. − Some bioresorbable micropumps were also developed, such as the poly( l -lactide- co -glycolide) (PLGA) osmotic micropump for delivering basic fibroblast growth factor (bFGF) and the poly(glycerol- co -sebacic acid) (PGS) micropump for releasing ciprofloxacin-HCl …”

Section: Microfluidics For Drug Delivery and Drug Carrier Fabricationmentioning

confidence: 99%

Microfluidics for Drug Development: From Synthesis to Evaluation

et al. 2021

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Drug development is a long process whose main content includes drug synthesis, drug delivery, and drug evaluation. Compared with conventional drug development procedures, microfluidics has emerged as a revolutionary technology in that it offers a miniaturized and highly controllable environment for bio(chemical) reactions to take place. It is also compatible with analytical strategies to implement integrated and high-throughput screening and evaluations. In this review, we provide a comprehensive summary of the entire microfluidics-based drug development system, from drug synthesis to drug evaluation. The challenges in the current status and the prospects for future development are also discussed. We believe that this review will promote communications throughout diversified scientific and engineering communities that will continue contributing to this burgeoning field.

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“…Many different systems have been developed based on the principle of osmotic pressure and some of these systems have reached the market. Elementary osmotic pump (EOP) [5][6][7], sandwiched osmotic tablet system (SOTS) [8], pushpull systems (PPOP) [9][10][11][12], controlled porosity osmotic pumps (CPOP) [13,14], tablet in tablet (TNT) cores [15], Asymmetric membrane capsule for osmotic drug delivery [12,16], osmotic systems made by swellable-core technology [17] and swellable elementary osmotic pump(SEOP) [18,19] can be noted.…”

Section: Introductionmentioning

confidence: 99%

Nano-suspension coating as a technique to modulate the drug release from controlled porosity osmotic pumps for a soluble agent

Bahari

Javadzadeh

Barzegar-Jalali

et al. 2017

Colloids and Surfaces B: Biointerfaces

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, Nanosuspension coating as a technique to modulate the drug release from controlled porosity osmotic pumps for a soluble agent, Colloids and Surfaces B: Biointerfaces http://dx.doi.org/10. 1016/j.colsurfb.2017.02.007 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights  Hydrophilic pore formers in nano range was prepared using ball mill  Pore former concentration in the coating had crucial effect on coating integrity  Gelling agent concentration in the coating had crucial effect on coating integrity  Nanosuspension coating tackle the issue associated with conventional osmotic pump 2 Grasphical abstract AbstractIn controlled porosity osmotic pumps (CPOP), usually finding a single solvent with a capability to dissolve both film former (hydrophobic) and pore former (hydrophilic) is extremely challenging.Therefore, the aim of the present investigation was to tackle the issue associated with controlled porosity osmotic pump (CPOP) system using nano-suspension coating method. In the present study 4-Amino pyridine was used as a highly water soluble drug. In this method, a hydrophilic pore former (sucrose or mannitol) in nano range was suspended in polymeric coating solution using ball-mill. The performance of the prepared formulations was assessed in terms of D12h (cumulative release percent after 12 hours), Devzero (mean percent deviation of drug release from zero order kinetic), tL (lag time of the drug release) and RSQzero. The results revealed that gelling agent amount (HPMC E15LV) in core and pore former concentration in SPM had crucial effect on SPM integrity. All the optimised formulations showed a burst drug release due to fast dissolving nature of the pore formers. Results obtained from 3 scanning electron microscopy demonstrated the formation of nanopores in the membrane where the drug release takes place via these nanopores. Nano suspension coating method can be introduced as novel method in formulation of CPOPs.

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A novel asymmetric membrane osmotic pump capsule with in situ formed delivery orifices for controlled release of gliclazide solid dispersion system

Cited by 22 publications

References 63 publications

Formulation of Dispersed Gliclazide Powder in Polyethylene Glycol–Polyvinyl Caprolactam– Polyvinyl Acetate Grafted Copolymer Carrier for Capsulation and Improved Dissolution

Formulation of Dispersed Gliclazide Powder in Polyethylene Glycol–Polyvinyl Caprolactam– Polyvinyl Acetate Grafted Copolymer Carrier for Capsulation and Improved Dissolution

Microfluidics for Drug Development: From Synthesis to Evaluation

Nano-suspension coating as a technique to modulate the drug release from controlled porosity osmotic pumps for a soluble agent

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