A novel approach for UV-patterning with binary polymer brushes

Li, Lifu; Nakaji-Hirabayashi, Tadashi; Kitano, Hiromi; Ohno, Kohji; Saruwatari, Yoshiyuki; Matsuoka, Kazuyoshi

doi:10.1016/j.colsurfb.2017.10.022

Cited by 11 publications

(8 citation statements)

References 40 publications

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“…S4), we believed that our results had corroborated well with previous literature on hydrophobic surfaces, especially when our XPS had also revealed a mixture of both CH 3 and surface OH (a result of steric hindrance on Si (111) surfaces). As many previous reports on using mixed SAM had often relied on large polymeric system to obtain similar wettability profile (~60-80°) as well as cell/protein repellency effect [81][82][83] , what that had set our work apart is the fact that grafting of short cyclic monolayer is already sufficient to obtain similar findings. Interestingly, while 1,7 octadiyne surfaces in our work had also shown similar hydrophobicity profiling, we did not observe high anti-biofouling effects.…”

Section: Discussionmentioning

confidence: 97%

Anti-Adhesion Behavior from Ring-Strain Amine Cyclic Monolayers Grafted on Silicon (111) Surfaces

Ching

Huang

Hsu

et al. 2020

Sci Rep

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In this manuscript, a series of amine tagged short cyclic molecules (cyclopropylamine, cyclobutylamine, cyclopentylamine and cyclohexylamine) were thermally grafted onto p-type silicon (111) hydride surfaces via nucleophilic addition. The chemistries of these grafting were verified via XPS, AFM and sessile droplet measurements. Confocal microscopy and cell viability assay was performed on these surfaces incubated for 24 hours with triple negative breast cancer cells (MDA-MB 231), gastric adenocarcinoma cells (AGS) endometrial adenocarcinoma (Hec1A). All cell types had shown a significant reduction when incubated on these ring-strain cyclic monolayer surfaces than compared to standard controls. The expression level of focal adhesion proteins (vinculin, paxilin, talin and zyxin) were subsequently quantified for all three cell types via qPCR analysis. Cells incubate on these surface grafting were observed to have reduced levels of adhesion protein expression than compared to positive controls (collagen coating and APTES). A potential application of these anti-adhesive surfaces is the maintenance of the chondrocyte phenotype during in-vitro cell expansion. Articular chondrocytes cultured for 6 days on ring strained cyclopropane-modified surfaces was able to proliferate but had maintained a spheroid/aggregated phenotype with higher COL2A1 and ACAN gene expression. Herein, these findings had help promote grafting of cyclic monolayers as an viable alternative for producing antifouling surfaces.

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Section: Discussionmentioning

confidence: 97%

Anti-Adhesion Behavior from Ring-Strain Amine Cyclic Monolayers Grafted on Silicon (111) Surfaces

Ching

Huang

Hsu

et al. 2020

Sci Rep

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“…It is important to note that we primarily focus on planar substrates; MPBs on curved surfaces and particles have been reviewed previously and provide promising platforms for materials that can be selectively shuttled between phases in multi-component mixtures [55]. Note that there are also so-called "binary" or "ternary" polymer brushes, patterned manually in nanometer-or micron-scales (e.g., using a photomask) on a surface [56][57][58][59][60][61][62][63][64]. We do not consider these as "binary or ternary mixed polymer brushes" here, since their tethered ends are not inherently mixed on a molecular level.…”

Section: Introductionmentioning

confidence: 99%

Mixed Polymer Brushes for “Smart” Surfaces

Pester

2020

Polymers

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Mixed polymer brushes (MPBs) are composed of two or more disparate polymers covalently tethered to a substrate. The resulting phase segregated morphologies have been extensively studied as responsive “smart” materials, as they can be reversible tuned and switched by external stimuli. Both computational and experimental work has attempted to establish an understanding of the resulting nanostructures that vary as a function of many factors. This contribution highlights state-of-the-art MPBs studies, covering synthetic approaches, phase behavior, responsiveness to external stimuli as well as novel applications of MPBs. Current limitations are recognized and possible directions for future studies are identified.

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“…Because of the different properties (e.g., different biocompatibility, molecular recognition, and electron conductivity) arranged on a single surface, the patterned polymer brushes allow applications in, e.g., bio-microarray detection, molecular recognition analytical devices, and microelectronic devices. , Surface-initiated living radical polymerization has been used to prepare such patterned polymer brushes from prepatterned initiators. ,,,− Several advanced techniques, such as electron-beam lithography, , interference laser lithography, , scanning-probe lithography, − and microcontact printing, , have successfully been used to prepare the prepatterned initiators with controlled surface densities. Not only the high-energy beam and laser but also low-energy UV light (≤254 nm), plasma, and UV/ozone were exploited to degrade alkyl bromide surface-initiators of atom transfer radical polymerization (ATRP). − However, the UV degradation of the alkyl bromides is time-consuming (≥3.5 h), limiting its extensive use.…”

Section: Introductionmentioning

confidence: 99%

Effective Synthesis of Patterned Polymer Brushes with Tailored Multiple Graft Densities

Wang

Yong

Goto

2019

ACS Appl. Mater. Interfaces

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This paper reports an effective method to prepare patterned polymer brushes on surfaces with tailored graft densities. High-density (concentrated), moderate-density (semidilute), and low-density (dilute) polymer brushes were fabricated in patterned manners, offering defined 3D-patterned structures. This method uses a middle/near-UV (≥ 250 nm) lamp and needs only a short time (≤ 10 min) to fabricate pre-patterns of the initiator, in sharp contrast to the previous high-energy lithography and time-consuming processes. The obtained patterned brush served as a molecular (protein) repellent/adsorptive interface based on a graft-density dependent size-exclusion effect. This method is facile and accessible to wide ranges of tunable density and pattern shape, which are attractive for extensive use.

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A novel approach for UV-patterning with binary polymer brushes

Cited by 11 publications

References 40 publications

Anti-Adhesion Behavior from Ring-Strain Amine Cyclic Monolayers Grafted on Silicon (111) Surfaces

Anti-Adhesion Behavior from Ring-Strain Amine Cyclic Monolayers Grafted on Silicon (111) Surfaces

Mixed Polymer Brushes for “Smart” Surfaces

Effective Synthesis of Patterned Polymer Brushes with Tailored Multiple Graft Densities

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