A novel approach for preparation of CL-20 nanoparticles by microemulsion method

Bayat, Yadollah; Zarandi, Maryam; Zarei, Mohammad; Soleyman, Rouhollah; Zeynali, Vida

doi:10.1016/j.molliq.2013.12.028

Cited by 46 publications

(24 citation statements)

References 30 publications

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“…Use of μEs for the preparation of NDs is still in its early stages . In this study, we have made an effort to use biocompatible μE for devising fluoroquinolone loaded formulation, which has been useful for the NPs formation and has improved drug dissolution profile and stability when compared to the conventional formulation.…”

Section: Introductionmentioning

confidence: 99%

Structural Insights into the Microemulsion‐Mediated Formation of Fluoroquinolone Nanoantibiotics

et al. 2018

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Microemulsions (μEs) are being exploited as a potential route for yielding an extensive range of nanoparticles of different chemical nature, shapes and sizes. Nanodrugs offer new avenues for structuring better “drug delivery systems”. In this study, an oil‐in‐water (o/w) μE formulation comprising N‐butyl acetate/polysorbate 80/ethanol/water was developed for the preparation of nanoparticles of fluoroquinolone antibiotics (FLQ‐NPs). A pseudoternary phase diagram was mapped at constant surfactant/cosurfactant (1:2), revealing improved and high loading of FLQs in an optimum μE formulation. The as‐formulated μE showed high loading of FLQs as; levofloxacin (4.20 wt.%), ciprofloxacin (3.16 wt.%), moxifloxacin (2.53 wt.%), gatifloxacin (1.36 wt.%), ofloxacin (0.70 wt.%). Fourier transform IR analysis indicated good compatibility of each FLQ drug with μE excipients. However, dynamic light scattering showed an increase in the average particle size of the μE on drug loading, indicating the accumulation of FLQ at interface layer of the micelle. Additionally, lyophilized levofloxacin (a selected antibiotic) showed long‐term stability, amorphous morphology and improved dissolution rate, inspected by scanning transmission electron microscopy, X‐ray diffraction and electronic spectroscopy, respectively. Moreover, fluorescence measurements suggested the interfacial vicinity of levofloxacin within the μE domain, which may support controlled release of drug during systemic circulation.

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Section: Introductionmentioning

confidence: 99%

Structural Insights into the Microemulsion‐Mediated Formation of Fluoroquinolone Nanoantibiotics

et al. 2018

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“…In recent years, micro-and nanostructured energetic materials have attracted considerable interest for improving their performances in energy release and ignition properties, and potential applications in microscale energy-demanding system [1][2][3][4]. It was reported that nanocrystals of energetic materials can not only decrease the mechanical sensitivity, but also help for improving the combustion and detonation properties as compared to coarse energetic materials [5][6][7][8]. Various techniques, such as electrospray crystallization, ultrasound-and spray-assisted crystallization, direct write ink-jet, microemulsion, rapid expansion of supercritical solutions, solvent-antisolvent crystallization, and sol-gel method, had been employed to fabricate nanocrystals of high explosives, including cyclotrimethylene trinitramine (RDX) [9], cyclotetramethylene tetranitramine (HMX) [10,11], hexanitrohexaazaisowurtzitane (CL-20) [12], 1,1-diamino-2,2-dinitroethylene (FOX-7) [13], 5-nitro-2,4-dihydro-3H-1,2,4-triazole-3-one (NTO) [14], 2,2',4,4'-,6,6'-hexanitrostilbene (HNS) [15], 1,3,5-triamino-2,4,6-trinitrobenzene (TATB) [16,17], etc.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Properties of Submicrometer‐Sized LLM‐105 via Spray‐Crystallization Method

Zhang

Yang

et al. 2014

Propellants Explo Pyrotec

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Submicrometer-sized 2,6-diamino-3,5-dinitropyrazine-1-oxide (LLM-105) crystals were prepared by spraycrystallization method with dimethyl sulfoxide (DMSO) and ultra-pure water with surfactant as the solvent and anti solvent, respectively. Submicrometer-sized LLM-105 particles were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and particle size analysis. The thermal stability and sensitivity properties of submicrometersized LLM-105 were also investigated. The results revealed that the submicrometer-sized LLM-105 particles are sphere-like in morphology with a narrow particle size distribution at the range of 100-600 nm. The submicrometer-sized LLM-105 has a lower exothermic peak at about 343.7 8C compared with the synthesized material. Sensitivity tests showed that submicrometer-sized LLM-105 is more insensitive under impact stimulus with a drop height (H 50 ) of 102 cm. The submicrometer-sized LLM-105-based PBX is more sensitive for short impulse shock wave that can be initiated at lower initiation current.

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“…As one class of them, nano-explosives have attracted much attention due to their potential application in micro thrusters [6] and micro-electromechanical systems [7]. Recently, benefiting from the development of nanotechnology, a variety of nano-explosives such as 1,3,5-trinitro-1,3,5-triazinane (RDX) [8,9], HMX [10,11], 1,1-diamino-2,2-dinitroethene (FOX-7) [12,13], 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazawurt-zitane (CL-20) [14,15] and TATB [16,17] have been successfully prepared by various approaches. With respect to LLM-105, Zhang et al [18] utilized a spray-crystalline method to prepare submicron size LLM-105.…”

mentioning

confidence: 99%

Facile Fabrication of Nanoparticles Stacked 2,6‐diamino‐3,5‐dinitropyrazine‐1‐oxide (LLM‐105) Sub‐microspheres via Electrospray Deposition

Huang

Liu

Ding

et al. 2017

Propellants Explo Pyrotec

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In this study, nanoparticles stacked 2,6‐diamino‐3,5‐dinitropyrazine‐1‐oxide (LLM‐105) sub‐microspheres were successfully fabricated by electrospray deposition. These monodisperse sub‐microspheres with a diameter from 200–500 nm are composed of 50 nm nanoparticles, and after preserved six months these spheres retain the same structure and morphology. The effect of process parameter including flow rate and nozzle size on the size and morphology of sub‐microsphere is investigated. The results show that, for a given solution concentration the nozzle size has little effect while the flow rate shows a significant effect. The X‐ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT‐IR) results exhibit that the as‐prepared sub‐microspheres have the same crystal and chemical structure as the raw materials. The thermal behavior performed by simultaneous thermal analysis (TG‐DSC) verifies that in comparison to the raw materials sub‐microspheres have a lower onset degradation temperature.

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A novel approach for preparation of CL-20 nanoparticles by microemulsion method

Cited by 46 publications

References 30 publications

Structural Insights into the Microemulsion‐Mediated Formation of Fluoroquinolone Nanoantibiotics

Structural Insights into the Microemulsion‐Mediated Formation of Fluoroquinolone Nanoantibiotics

Preparation and Properties of Submicrometer‐Sized LLM‐105 via Spray‐Crystallization Method

Facile Fabrication of Nanoparticles Stacked 2,6‐diamino‐3,5‐dinitropyrazine‐1‐oxide (LLM‐105) Sub‐microspheres via Electrospray Deposition

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