A Novel Approach for Ligand Promoted Palladium (II)-Catalyzed Suzuki Coupling of Aryl Iodides and Bromides with Arylboronic Acid in Aqueous Media

Abstract

A highly efficient, environmental friendly, palladium (II) catalyzed ligand promoted Suzuki reaction in aqueous phase was developed in short reaction time (4 -5 h) at room temperature. The key for such a successful catalytic system was the use of suitable amount of co-solvent in the aqueous phase and reuse of palladium catalyst.

Synthesis of (E)-8-(3-Chlorostyryl)caffeine Analogues Leading to 9-Deazaxanthine Derivatives as Dual A2A Antagonists/MAO-B Inhibitors

“…Compound 14a and 14c were obtained respectively from the commercially available 7a and 9c . Compound 14b was obtained from 7b , which was synthesized by Suzuki reaction of 4-bromobenzaldehyde with 3-chlorophenylboronic acid . Formation of ethyl 2-azidocinnamate ( 8a , b ) by condensation of arylaldehyde ( 7a , b ) with ethyl azidoacetate in the presence of sodium ethoxide at 0 °C and subsequently pyrolysis of 8a , b in p -xylene a 150 °C gave the corresponding ethyl indole-2-carboxylate ( 9a , b ).…”

Green Route for Efficient Synthesis of Novel Amino Acid Schiff Bases as Potent Antibacterial and Antifungal Agents and Evaluation of Cytotoxic Effects

“…Water is nontoxic, safe, and cheap and never leads to menace to the environment [5][6][7][8][9][10]. The use of water as a solvent [11][12][13] is undoubtedly the best alternative as there are generally no harsh reaction conditions and no need of vigorous drying of the solvents.…”

Alum Catalyzed Simple, Efficient, and Green Synthesis of 2‐[3‐Amino‐5‐methyl‐5‐(pyridin‐3‐yl)‐1,5‐dihydro‐4H‐1,2,4‐triazol‐4‐yl]propanoic Acid Derivatives in Aqueous Media

“…Nowadays, many organic transformations have been carried out in water [ 1 – 3 ]. It is a unique solvent due to being readily available, inexpensive, nontoxic, safer, and environmentally benign.…”