A Novel Anticandidal Compound Containing Sulfur from Endophytic Fungus Emericella sp.

Mittal, Shweta; Shrivastava, Divya Rishi; Govil, Sumit; Kumar, Shailesh; Bisen, Prakash S.

doi:10.2174/2210315506666160513160732

Cited by 5 publications

(6 citation statements)

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“…The result from our study also indicated a significant anti-candidal activity exerted by ethyl acetate extract of C. ramicola IBRLCM127. There are also a few reports concerning this matter including the study conducted by Mittal et al (2016) that was successfully isolated a novel compound of N-[(2S,3aR, 6S,7aS)-6-acetamido-octahydro-1,3-benzothiazol-2-yl]2-(adamantan-1-yl) which derived from endophytic fungal Emericella sp. recovered from Azadirachta indica A. Juss (Neem) tree that showed a great potential in inhibiting the growth of C. albicans.…”

Section: )mentioning

confidence: 99%

Ceratobasidium ramicola IBRLCM127, an endophytic fungus isolated from Curcuma mangga Valeton & Zijp with strong anti-candidal activity

2019

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Ceratobasidium ramicola IBRLCM127, an endophytic fungus isolated from the rhizome of the local medicinal plant Curcuma mangga Valeton & Zijp, was found to possess significant anti-candidal activity. This fungal endophyte was cultivated in submerged fermentation system using yeast sucrose medium supplemented with host plant water extract and cultivated at 25°C, agitated at 120 rpm for 12 days. The ethyl acetate was used as a solvent to extract compounds in the fermentative broth. The fungal ethyl acetate extract demonstrated significant inhibitory zones toward cells of Candida albicans with minimum inhibitory concentration (MIC) value of 2.5 mg/ml, of which exerting yeastocidal effect. The time-kill study conducted at three distinct ethyl acetate concentrations (half MIC, MIC, and 2 MIC values) revealed that the growth of C. albicans cells was concentration-dependent. Yeastostatic activity was shown at lower concentration and yeastocidal activity was shown at higher concentration. The structural degeneration of the C. albicans cells after treated with ethyl acetate extract was observed under the scanning and transmission electron microscopes and the results exhibited various cell deformities including severe damage of the cell extracellularly and intracellularly which led to cell death beyond repair, thus suggesting that the extract could be a potential antifungal agent.

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Section: )mentioning

confidence: 99%

Ceratobasidium ramicola IBRLCM127, an endophytic fungus isolated from Curcuma mangga Valeton & Zijp with strong anti-candidal activity

2019

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“…C. macrophyllus [ 21 ], X. granatum [ 22 ], M. azedarach [ 23 ], T. sinensis [ 24 ], C. tagal [ 25 ], A. indica [ 26 ], T. monadelpha [ 27 ], T. longipes [ 28 ], D. binectariferum [ 29 ], and L. domesticum [ 30 ] are members of the Meliaceae family with endophytic fungi that create secondary metabolites. The 276 secondary metabolites isolated are composed of 82 terpenoids, 12 polyketides, nine lactones, six pyrones, one quinone, 15 anthraquinones, nine xanthones, 10 isocoumarines, 13 resorcylic acid lactones, 25 cytochalasins, 18 aromatics, one ester, seven quinols, 59 alkaloids, one nitro compound, and eight fatty acids and sugars ( Figure 1 ) [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64...…”

Section: Phytochemistrymentioning

confidence: 99%

“…In 2016, 2 S ,3a R ,6 S ,7a S )-6-acetamido-octahydro-1,3-benzothiazole-2-yl-2-(adamantan-1-yl)acetamide ( 267 ) was discovered by Mittal et al This compound ( 267 ) was isolated from Emericella sp. derived from A. indica twig [ 63 ], and the structures can be seen in Figure 11 .…”

Section: Phytochemistrymentioning

confidence: 99%

Phytochemistry and Biological Activities of Endophytic Fungi from the Meliaceae Family

2023

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Meliaceae plants are found worldwide in tropical or subtropical climates. They are important ethnobotanically as sources of traditional medicine, with 575 species and 51 genera. Previous research found that microorganisms are plant pioneers to produce secondary metabolites with diverse compound structures and bioactivities. Several plants of the Meliaceae family contain secondary metabolites isolated from endophytic fungi. Furthermore, related articles from 2002 to 2022 were collected from SciFinder, Google Scholar, and PubMed. About 276 compounds were isolated from endophytic fungi such as terpenoids, polyketides, lactones, pyrones, quinone, anthraquinones, xanthones, coumarines, isocoumarines, resorcylic acid lactones, cytochalasins, aromatics, ester, quinols, alkaloids, nitro compound, fatty acids, and sugars with bioactivities such as antioxidant, antibacterial, antifungal, anti-influenza, neuroprotective activities, anti-HIV, cytotoxic, allelopathic, anti-inflammatory, antifeedant effects, and BSLT toxicity. Meanwhile, secondary metabolites isolated from endophytic fungi were reported as one of the sources of active compounds for medicinal chemistry. This comprehensive review summarizes the ethnobotanical uses and secondary metabolites derived from Meliaceae endophytic fungi.

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“…Despite its excellent antifungal activities, nevertheless it showed poor bioavailability since it is lipid-soluble and displays very high toxicity to mammalian cells due to its aldehyde nature. Therefore, we have designed a series of novel compounds via structural modification of the natural scaffold by replacing the aldehyde group with a 1,2,4-triazole ring carrying a substituted benzylsulfanyl moiety [13], presumably, to generate new derivatives with enhanced physicochemical properties and safety profiles. The newly designed azoles were formulated into polymeric NPs in order to enhance the compounds' bioavailability, reduce the toxicity and prolong the activities.…”

Section: Introductionmentioning

confidence: 99%

Essential Oil-Based Design and Development of Novel Anti-Candida Azoles Formulation

et al. 2020

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Candida is the most common fungal class, causing both superficial and invasive diseases in humans. Although Candida albicans is the most common cause of fungal infections in humans, C. auris is a new emergent serious pathogen causing complications similar to those of C. albicans. Both C. albicans and C. auris are associated with high mortality rates, mainly because of their multidrug-resistance patterns against most available antifungal drugs. Although several compounds were designed against C. albicans, very few or none were tested on C. auris. Therefore, it is urgent to develop novel effective antifungal drugs that can accommodate not only C. albicans, but also other Candida spp., particularly newly emergent one, including C. auris. Inspired by the significant broad-spectrum antifungal activities of the essential oil cuminaldehyde and the reported wide incorporation of azoles in the antifungal drugs, a series of compounds (UoST1-11) was designed and developed. The new compounds were designed to overcome the toxicity of the aldehyde group of cuminaldehyde and benefit from the antifungal selectivity of azoles. The new developed UoST compounds showed significant anti-Candida activities against both Candida species. The best candidate compound, UoST5, was further formulated into polymeric nanoparticles (NPs). The new formula, UoST5-NPs, showed similar activities to the nanoparticles-free drug, while providing only 25% release after 24 h, maintainng prolonged activity up to 48 h and affording no toxicity. In conclusion, new azole formulations with significantly enhanced activities against C. albicans and C. auris, while maintaining prolonged action and no toxicities at lower concentrations, were developed.

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A Novel Anticandidal Compound Containing Sulfur from Endophytic Fungus Emericella sp.

Cited by 5 publications

References 0 publications

Ceratobasidium ramicola IBRLCM127, an endophytic fungus isolated from Curcuma mangga Valeton & Zijp with strong anti-candidal activity

Ceratobasidium ramicola IBRLCM127, an endophytic fungus isolated from Curcuma mangga Valeton & Zijp with strong anti-candidal activity

Phytochemistry and Biological Activities of Endophytic Fungi from the Meliaceae Family

Essential Oil-Based Design and Development of Novel Anti-Candida Azoles Formulation

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