A novel anticancer and antifungus phenazine derivative from a marine actinomycete BM-17

Gao, Xiaochun; Lu, Yuanyuan; Xing, Yingying; Ma, Yihua; Lu, Jiansheng; Bao, Weiwei; Wang, Yiming; Xi, Tao

doi:10.1016/j.micres.2012.02.008

Cited by 115 publications

(60 citation statements)

References 54 publications

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“…The culture broth yielded a novel metabolite N-(2-hydroxyphenyl)-2-phenazinamine (NHP) and six known antibiotics. NHP displayed potent cytotoxicity against HepG2, A549, HCT-116 and COC1cell lines among which high cytoxicity was observed against HCT-116 with IC50 value of 27.82 μg/ml (Gao et al 2012).…”

Section: N-(2-hydroxyphenyl)-2-phenazinaminementioning

confidence: 99%

Ocean Dwelling Actinobacteria as Source of Antitumor Compounds

Gomathi

Gothandam

2016

Braz. arch. biol. technol.

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Section: N-(2-hydroxyphenyl)-2-phenazinaminementioning

confidence: 99%

Ocean Dwelling Actinobacteria as Source of Antitumor Compounds

Gomathi

Gothandam

2016

Braz. arch. biol. technol.

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“…90 μl of test strain suspension inoculated into all the wells except the first row. The plates were tested after incubated at 30° or 37° for 18 to 24 h. Results were registered in an ELISA reader, and IC 50 were calculated graphically from concentration-inhibition curves (8).…”

Section: Antimicrobial Activity Assaysmentioning

confidence: 99%

Fast identification of the antibacterial in Aspergillus species

Wang¹,

Duan

Yang

et al. 2017

Period Biol

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Abstract:Background Conclusions: Our study has significant scope on targeting antibacterial metabolites. The described method could also be used as a rapid and costeffective tool for screening other bioactivity products. As such, this article could offer a fast approach to isolate drug-lead compounds from microorganisms.IntroductIon A spergillus genus is well known for its medical and commercial importance (1). They are prolific producers of lifesaving drugs, devastating toxins, or mass produced industrial enzymes (2). Many clinically beneficial secondary metabolites are produced by Aspergillus genus, such as lovastatin, terrein, griseofulvin. Lovastatin, also known as mevinolin or monacolin K, is effective clinical drug used for reducing serum cholesterol and slowing the progression of atherosclerosis. Lovastatin and its related compounds inhibit cholesterol synthesis by inhibiting the rate-limiting step in cellular cholesterol biosynthesis (3). Terrein, one of Aspergillus major secondary metabolites has ecological, antimicrobial, antiproliferative and antioxidative activities (4). Some strains of Aspergillus can biosynthesize gluconic acid which is a bulk

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“…Although, commonly red in color and share a common pyrrolyldipyrromethane structural core. These features have made these class of pigments subjected to various researches during last decade which resulted in identifi cation of them from Streptoverticillium (Gerber and Stahly 1975 ), Streptomyces (Pusecker et al 1997 ), Pseudonocardia and Actinomadura (Maskey et al 2003c ), Streptimonospora , and Nocardiopsis (Gao et al 2012 ). …”

Section: Phenazine and Prodigininesmentioning

confidence: 99%

Biotechnological Exploitation of Actinobacterial Members

Hamedi

Mohammadipanah

Panahi

2015

Sustainable Development and Biodiversity

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Microbial-derived products, while do not have many environmental side effects of their synthetic counterparts, have proved more effi cient than those synthetically obtained. The nature has provided a treasure of microorganisms with capabilities to produce vast variety of novel compounds. This ability has been arised during long last of evolution and adaptation to diverse chemical and physical microenviroments. Microbial-derived metabolites have made their own space in industries and therefore human life. Among these microorganisms, halophilic and halotolerant actinobacteria are recently gaining much attentions. Metabolites and biological functions from halophilic or halotolerant members of this phylum of bacteria may resolving the ever-increasing thirst of industry for metabolites with salttolerancy to cope a range of issues from environmental pollution to diseases and world's hunger. In the current chapter, it has been tried to introduce the less dealt group of halophilic and halotolerant actinobacteria, and shed light on their potential to be exploited in various industry sectors.

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A novel anticancer and antifungus phenazine derivative from a marine actinomycete BM-17

Cited by 115 publications

References 54 publications

Ocean Dwelling Actinobacteria as Source of Antitumor Compounds

Ocean Dwelling Actinobacteria as Source of Antitumor Compounds

Fast identification of the antibacterial in Aspergillus species

Biotechnological Exploitation of Actinobacterial Members

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