A Novel Antibacterial Dental Resin Composite

Abstract

This study reports the synthesis and evaluation of a novel furanone-containing antibacterial resin composite. Compressive strength (CS) and S. mutans viability were used to evaluate the mechanical strength and antibacterial activity of the composites. With 5% to 30% addition of the furanone derivative, the composite showed no change in CS but a significant antibacterial activity with a 16% -68% reduction in the S. mutans viability. Further, the antibacterial activity of the modified composite was not affected by human saliva. The aging study implies that the modified composite may have a long-lasting antibacterial function. Within the limitations of this study, it appears that this experimental resin composite may potentially be developed into a clinically attractive dental restorative due to its high mechanical strength and antibacterial function.

A modified polyvinylchloride surface with antibacterial and antifouling functions

“…This greatly reduces the potential cytotoxicity from the antibacterial derivatives to the surrounding tissues. In these studies, we also found that the modified restoratives did not significantly interact with human saliva, limiting negative protein effects on antibacterial functions, unlike quaternary ammonium salt‐containing materials …”

“…Not long ago, we have found that the derivatized 2(5 H )‐furanone compounds exhibited significant antibacterial functions without proteins interference . We have validated this antibacterial effect on dental restoratives . These derivatives were covalently linked to dental polymers or dental composites, resulting in killing bacteria or inhibiting bacterial growth by simple contact but not via release or leaching .…”

“…Another type of new antimicrobial compounds, furanone‐containing molecules, has been reported to show a broad spectrum of biological and physiological properties including but not limited to antibiotic, antitumor, hemorrhagic, and insecticidal activities, although their biological mechanisms are still under investigation . Our previous studies using the 3,4‐dichloro‐5‐hydroxy‐2(5 H )‐furanone‐containing polymer‐composed dental composites have been found effective in inhibiting the growth of the oral bacterium Streptococcus mutans . To explore the application of 3,4‐dichloro‐5‐hydroxy‐2(5 H )‐furanone in surface modification research, we proposed to introduce 3,4‐dichloro‐5‐hydroxy‐2(5 H )‐furanone through a polymerizable molecule 2‐hydroxyethyl methacrylate via a covalent bond linkage into the hydrophilic PVDCS, covalently link the PVDCS to the activated PVC surface, and investigate the effect of the attached polymer on antifouling and antibacterial functions of the modified surface.…”

“…34 We have validated this antibacterial effect on dental restoratives. 34,35 These derivatives were covalently linked to dental polymers or dental composites, resulting in killing bacteria or inhibiting bacterial growth by simple contact but not via release or leaching. 34,35 This greatly reduces the potential cytotoxicity from the antibacterial derivatives to the surrounding tissues.…”

“…34,35 These derivatives were covalently linked to dental polymers or dental composites, resulting in killing bacteria or inhibiting bacterial growth by simple contact but not via release or leaching. 34,35 This greatly reduces the potential cytotoxicity from the antibacterial derivatives to the surrounding tissues. In these studies, we also found that the modified restoratives did not significantly interact with human saliva, limiting negative protein effects on antibacterial functions, 34,35 unlike quaternary ammonium saltcontaining materials.…”